Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning

Abstract

Nanosized sustainedrelease drug depots fabricated using modified tri-axial electrospinning, Acta Biomaterialia (2017), doi: http:// dx.doi.org/10. 1016/j.actbio.2017.01.069 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning Abstract:Nanoscale drug depots, comprising a drug reservoir surrounded by a carrier membrane, are much sought after in contemporary pharmaceutical research. Using cellulose acetate (CA) as a filament-forming polymeric matrix and ferulic acid (FA) as a model drug, nanoscale drug depots in the form of core-shell fibers were designed and fabricated using a modified tri-axial electrospinning process. This employed a solvent mixture as the outer working fluid, as a result of which a robust and continuous preparation process could be achieved. The fiber-based depots had a linear morphology, smooth surfaces, and an average diameter of 0.62 ± 0.07 µm. Electron microscopy data showed them to have clear core-shell structures, with the FA encapsulated inside a CA shell. X-ray diffraction and IR spectroscopy results verified that FA was present in the crystalline physical form. In vitro dissolution tests revealed that the fibers were able to provide close to zero-order release over 36 h, with no initial burst release and minimal tailing-off. The release properties of the depot systems were much improved over monolithic CA/FA fibers, which exhibited a significant burst release and also considerable tailing-off at the end of the release experiment. Here we thus demonstrate the concept of using modified tri-axial electrospinning to design and develop new types of heterogeneous nanoscale biomaterials.

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“…molecular composites. Certainly, as a result of the very fast drying process, the macroscale structure of the spray head is reproduced in the products on the microscale, such as core-shell structure from the coaxial electrospinning/electrospraying, Janus structure from side-byside electrospinning/electrospraying and tri-layer structure from tri-axial electrospinning [10][11][12][13][14]. Electrospraying apparently is a very simple process.…”

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“…Often, secondary interactions between the components in the amorphous composites are very important for their stable coexistence, preventing the re-crystallization of drug molecules and also the possible solid phase separation within the solid particles [22][23][24][25]. For disclosing the potential secondary interactions between the components, FTIR is one of the most important and broadest methods for detecting the potential secondary interactions, such as the hydrogen bonding and hydrophobic interactions, which can be speculated from the appearance or disappearance of absorbance peaks, blue or red shifts of some characteristic peaks of the raw materials.…”

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“…An electrospinning system is often composed of four components, i.e. the high-voltage power supply, the working fluid driving pump, the spinneret and the fiber collector [9][10][11] . The technique essentially involves making a solution of a polymer (often with a functional component) in a volatile solvent, and ejecting this from a syringe fitted with a metal needle (the spinneret).…”