Preparation of monoethyl fumarate-based molecularly imprinted polymers and their application as a solid-phase extraction sorbent for the separation of scopolamine from tropane alkaloids

Abstract

Monoethyl fumarate with two functional groups was introduced to prepare a MIP for the separation of scopolamine from tropane alkaloids.

Occurrence and Chemistry of Tropane Alkaloids in Foods, with a Focus on Sample Analysis Methods: A Review on Recent Trends and Technological Advances

“…The MISPE process (with 100 mg of MIP) was applied to extract TAs from Przewalskia tangutica fruits, obtaining recoveries from 82 to 102% [49] (Table 7). In a more recent work, an MIP prepared by precipitation polymerization [50] but using Sc as a template, monoethyl fumarate (MFMA) as a functional monomer, ethylene dimethacrylate (EGDMA) as a cross-linker and 2,2-azobisisobutylnitrle (AIBN) as an initiator was also evaluated. MFMA was selected because it contributed to the enhancement of the adsorption capacity and selectivity of MIP, owing to the unique monomer structure [50,51].…”

“…In a more recent work, an MIP prepared by precipitation polymerization [50] but using Sc as a template, monoethyl fumarate (MFMA) as a functional monomer, ethylene dimethacrylate (EGDMA) as a cross-linker and 2,2-azobisisobutylnitrle (AIBN) as an initiator was also evaluated. MFMA was selected because it contributed to the enhancement of the adsorption capacity and selectivity of MIP, owing to the unique monomer structure [50,51]. The material obtained was applied in the MISPE procedure to determine Sc in plant samples obtaining recoveries between 96 and106% [50] (Table 7).…”

“…MFMA was selected because it contributed to the enhancement of the adsorption capacity and selectivity of MIP, owing to the unique monomer structure [50,51]. The material obtained was applied in the MISPE procedure to determine Sc in plant samples obtaining recoveries between 96 and106% [50] (Table 7). The good recovery of Sc was maintained after 25 cycles, which indicates the good stability of the material.…”

An organic transistor for the selective detection of tropane alkaloids utilizing a molecularly imprinted polymer

“…[29][30][31][32][33][34][35] With this three-dimensional recognition space, MIPs were shown to successfully detect tropane drugs. [36][37][38] However, previous works on the use of MIPs for the detection of atropine did not report on the selective discrimination of (S)hyoscyamine. [39][40][41][42] Besides, previous reports have confirmed that MIPs can be formed as thin layers or membranes on substrates including electrodes, [43][44][45][46] interfacing MIPs with the extended-gate electrode should be possible.…”

Molecularly Imprinted Chalcone-Branched Polyimide-Based Chemosensors with Stripe Nanopatterns for the Detection of Melittin

“…As one of the techniques that meet these requirements, molecular imprinting (MI) allows the formation of recognizable binding sites in a polymer matrix through crosslinking in the presence of a target material (template) to be recognized. Owing to the advantages of MI such as easy manufacturing, ease of mass production, and breadth of functional material selection, molecularly imprinted polymers (MIPs) are widely utilized in a variety of fields, including separation science, − drug delivery, , and sensors. − However, the imprints of large biomolecules such as peptides, proteins, and cells face limitations owing to their large size, chemical and structural complexity, and environmental instability . To overcome these limitations, various molecular imprinting strategies have been employed, including nanoparticles, , nano/microstructures, , epitopes, − and surface imprinting. , Several molecular imprinting studies ,− that have recently been conducted used water-soluble monomers similar or identical to the initially proposed acrylate and acrylamide-based monomers for protein imprinting. , Concerning MIP-related studies for MEL selective recognition, only water-soluble monomers were used following the initially proposed strategies. , However, such MIP-based hydrogels exhibited low mechanical properties because of the functional damage of imprinted cavities during template removal in harsh environmental conditions.…”