An organic transistor for the selective detection of tropane alkaloids utilizing a molecularly imprinted polymer

Zhou, Qi; Sasaki, Yoko; Ohshiro, Kohei; Fan, Haonan; Montagna, Valentina; Gonzato, Carlo; Haupt, Karsten; Minami, Tsuyoshi

doi:10.1039/d2tb01067d

Cited by 11 publications

(10 citation statements)

References 69 publications

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“…[182] Since the polymer film can be designed with several monomers and/or cross-linker molecules, the variation of one of mixture components can have a huge impact not only on the sensitivity of the sensor but also on the transducer used to convert a given signal. For this reason, these films have found application with several readout technologies such as: HTM, [76,97,183] EIS, [76] CV, [184,185] DPV, [186][187][188][189] QCM, [70,[190][191][192] GC-MS, [193,194] SPR, [195,196] APGC-MS/MS, [197] UHPLC-PDA, [198] UV-Vis. [199] Figure 8.…”

Section: Thin Filmsmentioning

confidence: 99%

Deposition Methods for the Integration of Molecularly Imprinted Polymers (MIPs) in Sensor Applications

Caldara

Wissen

Cleij

et al. 2023

Advanced Sensor Research

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Offering high specificity and selectivity, molecularly imprinted polymers (MIPs) are synthetic polymeric affinity reagents that have become increasingly popular over the last couple of decades. Due to their long-term chemical and physical stability and low production cost, they have become an increasingly popular choice of receptor in the realm of sense. MIPs have therefore been associated with the detection of small molecules, proteins, cells, and pathogens, proving a highly robust and useful tool in the production of next-gen sensing platforms. This said, the development of these sensors pivots on one simple fact; these receptors have to be deposited onto a substrate for their desired application. The deposition of MIPs during sensor fabrication is therefore of great importance, with the field utilizing an array of mechanical and chemical deposition methods to achieve this. To this end, this review, therefore, sets aim at coalescing these different deposition approaches, classifying them, and outlining their utility when it comes to receptor design and integration. Thus, offering a knowledge base on current deposition methods, potential future approaches and analyzing where the MIP deposition field is tending toward.

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Section: Thin Filmsmentioning

confidence: 99%

Deposition Methods for the Integration of Molecularly Imprinted Polymers (MIPs) in Sensor Applications

Caldara

Wissen

Cleij

et al. 2023

Advanced Sensor Research

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“…3b). 86 MIPs were synthesized by free radical polymerization and optimized by different molar ratios. The in situ synthesized MIP SE showed excellent selective discrimination for ( S )-hyoscyamine.…”

Section: Materials Engineering For Enhancing the Sensing Efficiency O...mentioning

confidence: 99%

Integration of nanomaterial sensing layers on printable organic field effect transistors for highly sensitive and stable biochemical signal conversion

et al. 2023

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“…The technology of molecular imprinting was further applied for the synthesis of recognition cavities to selectively detect alkaloid drugs. [ 30 ] The analysis of alkaloid drugs is important because of their side effects causing psychological disease. Among them, atropine is a muscarinic‐blocking drug used for treating intoxications by organophosphorus analogous, which causes significant side effects (e.g., hallucination, memory impairment, and blurred vision).…”

Section: Ofet‐based Sensors Functionalized With Mips For Selective De...mentioning

confidence: 99%

“…[ 29 ] In addition, the amplification ability of OFET devices over conventional electrochemical methods such as DPV in chemical sensing has been clarified through our demonstrations. [ 30,102 ]…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Organic Transistor–Based Chemical Sensors for Real‐Sample Analysis

Sasaki

Minami

2023

Physica Status Solidi (a)

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An organic field‐effect transistor (OFET) is the representative amplification device showing a switching profile by applying a gate voltage, which indicates the potential as a chemical sensor device in combination with appropriate molecular recognition materials. On the other hand, the realization of OFET‐based chemical sensors for real‐sample analysis has been limited owing to the instability of organic semiconductive materials under ambient conditions and the difficulty of the designs of molecular recognition materials. Herein, this Review describes methodologies and actual approaches to maximize the potential of the OFETs as chemical sensor platforms based on fusion technologies between organic electronics and molecular recognition chemistry.This article is protected by copyright. All rights reserved.

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An organic transistor for the selective detection of tropane alkaloids utilizing a molecularly imprinted polymer

Abstract: This study proposes a chemical sensing approach for the selective detection of a tropane alkaloid drug based on an extended-gate-type organic field-effect transistor (OFET) functionalized with a molecularly imprinted polymer...

Cited by 11 publications

References 69 publications

Deposition Methods for the Integration of Molecularly Imprinted Polymers (MIPs) in Sensor Applications

Deposition Methods for the Integration of Molecularly Imprinted Polymers (MIPs) in Sensor Applications

Integration of nanomaterial sensing layers on printable organic field effect transistors for highly sensitive and stable biochemical signal conversion

Organic Transistor–Based Chemical Sensors for Real‐Sample Analysis

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