Preparation of magnesium-substituted hydroxyapatite powders by the mechanochemical–hydrothermal method

Suchanek, Wojciech L.; Byrappa, K.; Shuk, P.; Riman, Richard E.; Janas, Victor F.; TenHuisen, Kevor S.

doi:10.1016/j.biomaterials.2003.12.008

Cited by 320 publications

(224 citation statements)

References 28 publications

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“…On the other hand, Magnesium has a beneficial effect on the mineralization processes [13,14], osteoporosis [15] and might play a role on the osteoblastic and osteoclastic activities [16,17]. In addition, Mg is known to inhibit the crystallization of the hydroxyapatite, increase its dissolution and affect its thermal stability by lowering its decomposition temperature [18][19][20]. Thus, ceramics designed from hydroxyapatite containing magnesium and fluorine would be more suitable for dental and orthopedic applications.…”

Section: Introductionmentioning

confidence: 99%

Sintering and Mechanical Properties of Magnesium and Fluorine Co-Substituted Hydroxyapatites

Nsar¹,

Hassine²,

Bouzouita³

2013

JBNB

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Biological apatites contain several elements as traces. In this work, magnesium and fluorine co-substituted hydroxyapatites with the general formula Ca 9 Mg(PO 4 ) 6 (OH) 2-y F y , where y = 0, 0.5, 1, 1.5 and 2 were synthesized by the hydrothermal method. After calcination at 500˚C, the samples were pressureless sintered between 950˚C and 1250˚C. The substitution of F − for OH − had a strong influence on the densification behavior and mechanical properties of the materials. Below 1200˚C, the density steeply decreased for y = 0.5 sample. XRD analysis revealed that compared to hydroxylfluorapatite containing no magnesium, the substituted hydroxyfluorapatites decomposed, and the nature of the decomposition products is tightly dependent on the fluorine content. The hardness, elastic modulus and fracture toughness of these materials were investigated by Vickers's hardness testing. The highest values were 622 ± 4 GPa, 181 ± 1 GPa and 1.85 ± 0.06 MPa·m 1/2 , respectively.

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Section: Introductionmentioning

confidence: 99%

Sintering and Mechanical Properties of Magnesium and Fluorine Co-Substituted Hydroxyapatites

Nsar¹,

Hassine²,

Bouzouita³

2013

JBNB

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“…Based on the knowledge derived from biological mineralization systems, researchers, especially material scientists and chemists, are now seeking biomimetic apatite-related biomaterials. (Gibson and Bonfield, 2002;Suchanek et al, 2004;Morrissey et al, 2005), whereas the stability of crystals increases and solubility decreases in apatite with F substitution Okazaki et al, 1981). In addition to those, Sror Zn-substituted HAp crystals were synthesized by researchers.…”

Section: Fig 4 Hydroxyapatite Crystalmentioning

confidence: 99%

Biomimetic Fabrication of Apatite Related Biomaterials

Uddin¹,

Matsumoto²,

Okazaki³

et al. 2010

Biomimetics Learning From Nature

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“…Mg is present in the human body at concentrations between 1 and 6 mol %, and half of this amount is found in hard tissues. This element plays an important role in hard tissue metabolism, influencing osteoblast and osteoclast activity, and as a result, controlling the growth of bone [5][6][7][8][9][10][11]. In vivo studies have demonstrated that the presence of Mg in HA improves cell behaviour, adhesion with synthetic hard tissues, proliferation, and metabolic activation [12].…”

Section: Introductionmentioning

confidence: 99%

Low-temperature densification of Mg-doped hydroxyapatite fine powders under hydrothermal hot processing conditions

Montoya-Cisneros

Rendón-Ángeles

Matamoros-Veloza

et al. 2017

Ceramics International

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Abstract:Densification of calcium hydroxyapatite fine powders doped with different concentrations of Mg (2, 4 and 6 mol % Mg, MgHA) was successfully achieved for the first time in a nearly fully dense state using the 2 hydrothermal hot pressing (HHP) technique at low temperatures. Consolidation of MgHA powders was studied under different temperatures (150-240 ºC), reaction times (1-6 h), and powder particle size (20 nm-1.5 m). X-Ray diffraction analyses indicated that the particle densification under HHP conditions proceeded without any variation in the crystalline structure and regardless of the Mg content. The results from this work showed that an increase in temperature accelerates the reaction between MgHA particles and water (solvent) mixed during the hydrothermal treatment. Particle packing associated with bulk densification was achieved through a massive dissolution-recrystallisation mechanism, which induced the formation of small particles that rapidly crystallised on the surface of the partially dissolved original MgHA particles. The optimum conditions to obtain pellets with a high apparent density of 3.0758 ± 0.001 g/cm 3 and tensile strength value of 12.6 ± 0.6 MPa were 10 wt% of water at a temperature of 240 ºC with a 6 h reaction time and 6 mol % of Mg (MgHA3). The use of the HHP technique coupled with the fine particle size and reactivity of the MgHA precursor powders with water allowed us to produce disks that were compacted to a nearly full dense state with a low content of open porosity of 2.0 %.

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Preparation of magnesium-substituted hydroxyapatite powders by the mechanochemical–hydrothermal method

Cited by 320 publications

References 28 publications

Sintering and Mechanical Properties of Magnesium and Fluorine Co-Substituted Hydroxyapatites

Sintering and Mechanical Properties of Magnesium and Fluorine Co-Substituted Hydroxyapatites

Biomimetic Fabrication of Apatite Related Biomaterials

Low-temperature densification of Mg-doped hydroxyapatite fine powders under hydrothermal hot processing conditions

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