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Physico-chemical modifications of hydroxyapatite (HAp) materials are considered as pre-requisites for the development of new bioactive carrier materials for drug delivery and tissue engineering applications. Since acidic amino acids have well-documented affinities to both HAp and basic proteins, HAp modified by aspartic acid (Asp, acidic amino acid) might be one of the candidate substrates for a basic protein carrier. Here, we synthesized HAp in the presence of various concentrations of Asp and observed that HAp crystallinity and other physico-chemical properties were effectively modulated. Detailed studies indicated that Asp was not incorporated in the HAp crystal lattice, but rather was trapped in HAp crystals. Protein adsorption studies indicated that the HAp particles modified by Asp had a selective loading capacity for basic protein. Therefore, HAp particles containing Asp might have potential in drug delivery applications, especially as the carrier of basic proteins including bFGF and BMP.

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The proliferation of location-based social networks allows people to access location-based services as a group. We address Group Optimal Sequenced Route (GOSR) queries that enable a group to plan a trip with a minimum aggregate trip distance. The trip starts from the source locations of the group members, goes via a predefined sequence of different point of interests (POIs) such as a restaurant, shopping center and movie theater, and ends at the destination locations of the group members. The aggregate trip distance can be the total or the maximum trip distance of the group members. We introduce a novel approach to efficiently compute group optimal sequenced routes in road networks. We exploit elliptical properties to refine the POI search space and develop efficient algorithms for GOSR queries. Experiments show that our approach outperforms a naive approach significantly in terms of processing time and I/Os.

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