Preparation of in situ hydrogels loaded with azelaic acid nanocrystals and their dermal application performance study

Tomić, Ivona; Juretić, Marina; Jug, Mario; Pepić, Ivan; Čižmek, Biserka Cetina; Filipović-Grčić, Jelena

doi:10.1016/j.ijpharm.2019.04.016

Cited by 55 publications

(39 citation statements)

References 46 publications

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“…Through the rheograms, it is observed that the shear stress increases as the strain rate increases, characterizing the cosmetics studied as being pseudoplastic fluids, similar to the behavior found by Wang et al (2019), Rigon et al (2019), Fonseca-Santos et al (2019) and Tomic ´ et al (2019 who studied cosmetics and drugs made with different incipients.…”

Section: Viscosity Analysissupporting

confidence: 72%

Quality of cosmetics with active caffeine in cream and gel galenic bases prepared by compounding pharmacies

et al. 2022

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As there is a great scarcity of studies on the importance of good compounding practices in the preparation of cosmetics, this study aimed to evaluate the quality control of cosmetics with active ingredient caffeine for the treatment of cellulite prepared by magistrals pharmacies. Microbiological analyzes, pH determination, color measurement, quantification of the percentage of the active ingredient caffeine and viscosity in creams and gels with 5% of the active ingredient caffeine were performed. In the microbiological analysis, the presence of molds and yeasts was verified above the permitted level according to the Brazilian pharmacopoeia. The pH decreased over time, contributing to the formulations becoming more acidic. In the color parameters, it was found that pharmacy F4 showed a brownish color, both for the gel and for the cream. The percentage of caffeine was within specifications in all formulations and the viscosity remained unchanged during the shelf life of the samples. It is important that the compounding pharmacies demand more effectively the commitment of the team, as well as the analysis of the raw material according to the microbiological control regulations to translate into the quality of the products prepared by the pharmacies and favor the consumer in the effective objective that the product you want to achieve.

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Section: Viscosity Analysissupporting

confidence: 72%

Quality of cosmetics with active caffeine in cream and gel galenic bases prepared by compounding pharmacies

et al. 2022

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“…Successful treatment of skin disorders such as acne requires that a substantial amount of the applied drug dose is retained within the skin layers [58][59][60]. However, topically applied drugs might be absorbed in body areas close to the action site, where a local effect is expected.…”

Section: Ex Vivo Skin Permeation Studiesmentioning

confidence: 99%

Spironolactone-Loaded LeciPlexes as Potential Topical Delivery Systems for Female Acne: In Vitro Appraisal and Ex Vivo Skin Permeability Studies

et al. 2019

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Spironolactone (SP), an aldosterone antagonist with anti-androgen properties, has shown promising results in the treatment of female acne. However, its systemic side effects limit its clinical benefits. This study aimed to prepare and evaluate LeciPlexes for SP topical delivery. LeciPlexes were prepared by a one-step procedure and characterized using various techniques. Optimum LeciPlex preparation was incorporated into 1% methylcellulose gel and SP permeability was tested ex vivo in Sprague-Dawley rat skin. The maximum drug encapsulation efficiency obtained was 93.6 ± 6.9% and was dependent on the drug/phospholipid and surfactant/phospholipid ratios. A zeta potential of +49.3 ± 3.5 to +57.7 ± 3.3 mV and a size of 108 ± 25.3 to 668.5 ± 120.3 nm were observed for the LeciPlexes. FT-IR and DSC studies confirmed the incorporation of SP into the LeciPlexes through hydrophobic and hydrogen bonding interactions. SP release from the LeciPlex formulations was significantly slower than from the drug suspension. Cumulative SP permeated through rat skin from LeciPlex gel was about 2-fold higher than SP control gel. Cumulative SP deposited in the stratum corneum and other skin layers from the LeciPlex gel was about 1.8- and 2.6-fold higher than SP control gel, respectively. This new SP LeciPlex formulation is a promising carrier for the treatment of female acne.

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“…SLN developed by them was compared with commercial product Isotrex ® in 30 patients and was found to be superior to both inflammatory and non‐inflammatory lesions. In addition, all the patients were tolerated well by the SLN formulation 103 . For drug entrapment in SLN, the developed SLN contains ATRA and stearyl amine.…”

Section: Treatments For Acnementioning

confidence: 91%

Phytoconstituents‐loaded nanomedicines for the management of acne

Qadir¹,

Ullah

Gupta³

et al. 2022

J of Cosmetic Dermatology

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Background According to epidemiological data, a large percentage (80–90%) of adolescents suffer from acne vulgaris and approximately 30% of them need treatment. Possible outcomes of the inflammatory acne lesions are acne scars which, although they can be treated in several ways, may have a negative psychological impact on social life and relationships. There are three levels of acne: mild, moderate, and severe. The main types of acne scars are atrophic and hypertrophic scars. The pathogenesis of acne scarring is still not fully understood, but several hypotheses have been proposed. Aim The aim of this review is phytoconstituents‐loaded nanomedicines for the management of acne. Materials and methods An online literature assessment was steered for the acne, phytochemical composition, and nanomedicines, types of acne, types of nanotechnology. Appropriate information were taken from different electronic scientific databases such as Web of Science, Elsevier, Science Direct, Springer, PubMed, Google Scholar, etc., Additional data was summarized from textbooks, local prints, and scripts. Results Nanotechnology‐based nanomedicines provide a great coincidence for the enhancement in the efficacy and safety of pharmaco‐therapeutic agents for acne. Discussion In this review, we discuss the phytoconstituent that are natural compounds present in plants extensively used for the anti‐acne activity. Phytochemicals target cytokine signaling pathways and thus exhibit their anti‐acne activity. We further outline the advantages of loading phytoconstituents as a drug in nanocarriers such as emulsion, niosomes, SLN, and nanocrystal for better and improved topical treatment. Conclusion This review is mainly focused on the usage of herbal nanomedicines in acne, nano delivery carriers used in the delivery of phytoconstituents with an improved therapeutic profile and reduced toxicity. In recent years, phytoconstituents showing their anti‐acne potential, and phytoconstituents‐loaded nanomedicines have high treatment potential in the management of acne.

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Preparation of in situ hydrogels loaded with azelaic acid nanocrystals and their dermal application performance study

Cited by 55 publications

References 46 publications

Quality of cosmetics with active caffeine in cream and gel galenic bases prepared by compounding pharmacies

Quality of cosmetics with active caffeine in cream and gel galenic bases prepared by compounding pharmacies

Spironolactone-Loaded LeciPlexes as Potential Topical Delivery Systems for Female Acne: In Vitro Appraisal and Ex Vivo Skin Permeability Studies

Phytoconstituents‐loaded nanomedicines for the management of acne

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