Quality of cosmetics with active caffeine in cream and gel galenic bases prepared by compounding pharmacies

Abstract

As there is a great scarcity of studies on the importance of good compounding practices in the preparation of cosmetics, this study aimed to evaluate the quality control of cosmetics with active ingredient caffeine for the treatment of cellulite prepared by magistrals pharmacies. Microbiological analyzes, pH determination, color measurement, quantification of the percentage of the active ingredient caffeine and viscosity in creams and gels with 5% of the active ingredient caffeine were performed. In the microbiological analysis, the presence of molds and yeasts was verified above the permitted level according to the Brazilian pharmacopoeia. The pH decreased over time, contributing to the formulations becoming more acidic. In the color parameters, it was found that pharmacy F4 showed a brownish color, both for the gel and for the cream. The percentage of caffeine was within specifications in all formulations and the viscosity remained unchanged during the shelf life of the samples. It is important that the compounding pharmacies demand more effectively the commitment of the team, as well as the analysis of the raw material according to the microbiological control regulations to translate into the quality of the products prepared by the pharmacies and favor the consumer in the effective objective that the product you want to achieve.

Riscos químicos e biológicos relacionados ao uso indiscriminado de cosméticos

“…Esse ingrediente é altamente tóxico para essa faixa etária, devido á imaturidade da pele e suas estruturas, a penetração se torna mais facilitada para a entrada desses resíduos, sendo a pele facilmente agredida mecanicamente (HOPPE; CASTELLO, 2017). É de grande relevância que se façam a limpeza e a higienização adequada dos equipamentos antes e durante a produção dos produtos cosméticos, pois isso define a qualidade final do produto, caso ocorra a contaminação microbiológica, durante o processo produtivo, irá expor o usuário, pois a alta carga microbiana pode comprometer Brazilian Journal of Development, Curitiba, v.8, n.12, p. 77332-77347, dec., 2022 a estabilidade do produto e a perda de eficácia, ocorrendo a degradação dos ingredientes ativos (VOGEL et al, 2022). Os autores Lacrimante e Ribeiro (2014) afirmam que as principais vias de exposição às substancias químicas presentes em cosméticos são pele, mucosa e seus anexos, pelo contato direto.…”

Development of SEDDS formulation containing caffeine for dermal delivery

“…An arsenal of treatments for cellulite is available, the main ones being non-invasive and non-surgical, such as the use of topical pharmacological agents, and instrumental mechanisms, like therapy with radiofrequency and laser devices [5][6][7][8]. Anti-cellulite cosmetics are composed of active substances whose potential effects include lipolysis, lymphatic drainage, stimulation of peripheral microcirculation, reduction of oedema and stimulation of collagen production [9,10].…”

“…Numerous are ingredients used in topical presentations to treat cellulite. The main topical pharmacological treatment options include methylxanthines (caffeine, aminophylline, and theophylline), retinol and botanical derivatives [1,10]. Caffeine (1,3,7-trimethylpurine-2,6-di one) (CAF) is an alkaloid, belonging to the class of methylxanthines, which can be found in coffee, tea and some soft drinks.…”

“…The main action of this methylxanthine is to antagonize adenosine receptors and inhibit phosphodiesterase, which degrades cyclic AMP into inactive 5'AMP. This stimulates lipolysis of adipose tissue, reducing the accumulation of fat that occurs in cellulite and consequently improving the appearance of the skin [10,11]. CAF also has a stimulating effect on microcirculation by reducing the formation of free radicals [9,10].…”

“…This stimulates lipolysis of adipose tissue, reducing the accumulation of fat that occurs in cellulite and consequently improving the appearance of the skin [10,11]. CAF also has a stimulating effect on microcirculation by reducing the formation of free radicals [9,10].…”