Preparation of high-purity 68Ga solutions by ion exchange in mixed acetone-hydrochloric acid medium

Monolith-based 68Ga processing: a new strategy for purification to facilitate direct radiolabelling methods

“…The generator eluate has a large volume (5-10 mL) with a high concentration of H + (pH < 1) and can contain metal ion impurities (commonly aluminiumIJIII), ironIJIII) and zincIJII)). 6,8 All of which can potentially hinder complexation formation and reduce specific activity (SA). Thus, the eluate from a 68 Ge/ 68 Ga generator cannot currently be directly used for preparing radiopharmaceuticals that are in routine clinical practice.…”

“…Several methods for the processing of the generator eluate have been attempted in order to overcome the issues mentioned above including ion-exchange chromatography and fractionation. 7,8,[11][12][13] All of which individually mitigate some of the limitations of 68 Ga complexation. However, to date, no method delivers on all requirements to release the 68 Ga purified from other metal ions into small volumes of low H + concentration using a directly injectable solvent.…”

Gallium‐68‐labelled NOTA‐oligonucleotides: an optimized method for their preparation

“…After radiolabelling, an increase in metal content was observed for Cu (4000‐fold), Al and Fe (10‐fold) and Ti and Sn (2.5‐fold). All final concentrations were below 1 μM . Radiolabelling was performed 4 h after pre‐eluting the generator in order to obtain sufficient amounts of 68 Ga and assuring similar levels of impurities.…”