Monolith-based ⁶⁸Ga processing: a new strategy for purification to facilitate direct radiolabelling methods

Abstract

The post-processing of 68Ga generator eluate by means of a novel high capacity cation-exchange silica monolith column has been validated in this work.

The effects of trace metal impurities on Ga-68-radiolabelling with a tris(3-hydroxy-1,6-dimethylpyridin-4-one) (THP) chelator

“…Prior work has shown that the presence of a range of metal ions signicantly decrease RCY of 68 Ga-DOTA-based derivatives. 22,36,37 For example, in 68 Ga-radiolabelling reactions of DOTA-TATE, a 2 : 1 Pb 2+ : DOTA-TATE molar ratio decreases RCY of 68 Ga-DOTA-TATE to less than 80% (compared to near quantitative RCY in the 22,34,39 The amounts of metal ion impurities in our multi-sample ICP-MS analyses are of a similar magnitude to previously reported data for eluate deriving from generators with a titanium dioxide solid phase. 14,22,34 Our data on Al, Ti, Fe and Ga concentrations in eluates obtained six months apart from each other suggest that the concentration of these metal ions decreases over time/number of elutions.…”

The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules

“…If production scale is not a concern, then commercial and validated kits may provide a convenient solution. New technologies like microfluidic “lab-on-a-chip” devices which have been exemplified for metal-based radiochemistry may provide automated radiochemistry and quality control on a single, inexpensive device for clinical use (He et al 2017 , 2016 ; Zhang et al 2020 ). These devices may also serve to improve the issues of fluoride concentration and efficiency of [ 18 F]AlF labelling (He et al 2014 ; Wang and Dam 2020 ).…”

Synthesis of [68Ga]Ga-PSMA-11 using the iMiDEV™ microfluidic platform

“…[ 68 Ga]Ga 3+ concentration In conventional radiosynthesis of 68 Ga-peptides, different methods of 68 Ga-concentration are described in the literature using cation or anion exchange cartridges or even cationexchange silica-monolith columns. [25][26][27][28] Over the past 10 years, these methods together with fractionated elution have been used for purification of the 68 Ge/ 68 Ga generator eluate from metal impurities. 29 Current access to GMP grade generators has decreased the interest in these methods.…”