Synthesis of [⁶⁸Ga]Ga-PSMA-11 using the iMiDEV™ microfluidic platform

Abstract

We report herein the first production of [68Ga]Ga-PSMA-11 based on a microfluidic disposable cassette using iMiDEVTM synthesizer. The main steps of synthesis, 68Ga-concentration on the cation exchange resin followed by...

Microfluidic-based production of [68Ga]Ga-FAPI-46 and [68Ga]Ga-DOTA-TOC using the cassette-based iMiDEV™ microfluidic radiosynthesizer

“…However, after conducting heating element studies to compare the set value with the actual temperature value inside R2, it became evident that there was a significant variation between the two values. This discrepancy was attributed to the heat transfer between the heating component and the R2 chamber, which was further confirmed through a simulation study (Ovdiichuk et al 2023 ). The actual temperature inside the R2 chamber was approximately 70% of the set value.…”

“…Cassettes with a pressure drop of 0.2 to 0.3 bar were selected to perform trapping and elution on R1. The concentration of [ 68 Ga]GaCl 3 was performed using Chromafix PS-H + resin following the methodology proposed in previous studies (Ovdiichuk et al 2022 , 2023 ), and the elution technique was adapted according to the work of Mueller et al ( 2012 ). In this approach, R1 (50 µL) was filled with Chromafix PS-H + resin to concentrate the [ 68 Ga]GaCl 3 .…”

“…The iMiDEV™ batch-type microfluidic radiosynthesizer was investigated for the synthesis of fluorine-18 ( 18 F), carbon-11 ( 11 C), and 68 Ga-radiotracers at room temperature (Ovdiichuk et al 2021 , 2022 ; Mallapura et al 2022 ) as well as at elevated temperature (Ovdiichuk et al 2023 ). The radiolabeling of DOTA chelators with the 68 Ga-radionuclide requires high temperatures (León-Rodríguez and Kovacs 2008 ).…”

Microfluidic synthesis of radiotracers: recent developments and commercialization prospects

“…The chip contains a single liquid phase reactor and three solid phase columns that can be accessed at the operator's command via 34 pneumatically actuated microfluidic valves. 101 It also contains a series of vial connections on which preloaded vials of reagents are loaded. iMiDEV™ has been used to produce [ 18 F]NaF in a fully automated fashion in only 8 min with a RCY of 82%.…”

“…102 It was also shown to automatically synthesize quality 11 C and 68 Ga radiotracers. 101,103,104 This platform represents a major milestone as one of the few fully integrated and customizable microfluidic platforms for radiotracer synthesis.…”