Preparation of highly purified 68Ga solutions via ion exchange in hydrochloric acid–ethanol mixtures

Ларенков, А. А.; Bruskin, Alexander; Кодина, Г. Е.

doi:10.1007/s10967-015-4089-2

Cited by 9 publications

(8 citation statements)

References 28 publications

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“…As the neutral or negatively charged chloro complexes are unlikely to be recovered by the SILP, their formation could explain the selectivity of the SILP for scandium over iron from the feeds with ethanol. The formation of chloro complexes in ethanol solutions at low chloride concentration is not limited to iron, and it was also reported in a study on purification of 68 Ga from HCl–ethanol mixtures by an anion exchange resin …”

Section: Results and Discussionsupporting

confidence: 55%

“…The formation of chloro complexes in ethanol solutions at low chloride concentration is not limited to iron, and it was also reported in a study on purification of 68 Ga from HCl−ethanol mixtures by an anion exchange resin. 36 Scandium was preferentially sorbed over iron by the SILP from ethylene glycol feed (Figure 2a) as well. However, from the water−ethylene glycol feed, scandium and iron were equally sorbed and the selectivity was lost.…”

Section: ■ Results and Discussionmentioning

confidence: 97%

“…The formation of chloro complexes in ethanol solutions at low chloride concentration is not limited to iron, and it was also reported in a study on purification of 68 Ga from HCl–ethanol mixtures by an anion exchange resin. 36 …”

Section: Results and Discussionmentioning

confidence: 99%

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Separation of Scandium from Hydrochloric Acid–Ethanol Leachate of Bauxite Residue by a Supported Ionic Liquid Phase

Avdibegović

Binnemans

2020

Ind. Eng. Chem. Res.

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Solvometallurgy is a new branch of extractive metallurgy in which green organic solvents are used instead of aqueous solutions to improve selectivity in separation processes. In the present study, nonaqueous leaching of a Greek bauxite residue (BR) was performed and scandium was separated from other elements in the leachate by column chromatography. At first, the selectivity of sorbents for scandium(III) over iron(III) was tested in batch mode using various organic solvents. The following three sorbents were tested: (1) a carboxylic acid-functionalized supported ionic liquid phase (SILP), (2) silica (SiO 2 ), and (3) silica functionalized with ethylenediaminetetraacetic acid (SiO 2 –TMS–EDTA). The best separation of scandium and iron was achieved from ethanolic solution by the SILP. The BR was then leached with 0.7 mol L –1 HCl in ethanol or in water. The leaching efficiency of scandium with both lixiviants was similar. However, much less sodium was leached, and silica remained in solution when leaching was performed with the ethanolic lixiviant. By using ethanol as opposed to water, the serious drawback of silica gel formation that is taking place in the aqueous leachate of BR was circumvented. The sorption preference of the SILP for metal ions in the ethanolic leachate was partly reversed compared to the aqueous leachate. Iron was separated from other metals of the ethanolic BR leachate by a simple elution with ethanol. The formation of the anionic tetrachloroferrate(III) complex, [FeCl 4 ] − , enabled the selective elution. This complex was not observed in the aqueous leachate of BR. Scandium was separated from the vast majority of other components of the BR by elution with 0.1 mol L –1 H 3 PO 4 .

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Section: Results and Discussionsupporting

confidence: 55%

Section: ■ Results and Discussionmentioning

confidence: 97%

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Separation of Scandium from Hydrochloric Acid–Ethanol Leachate of Bauxite Residue by a Supported Ionic Liquid Phase

Avdibegović

Binnemans

2020

Ind. Eng. Chem. Res.

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“…68 Ge/ 68 Ga generator (Cyclotron Co., Ltd., Obninsk, Russia) with the initial activity of 1850 MBq was used. Post-processing of generator eluate was performed with HCl-ethanol method [44]. The final purified and concentrated solution of 68 Ga was obtained in 0.1 M HCl aq.…”

Section: Ge/ 68 Ga Generatormentioning

confidence: 99%

“…In the ongoing clinical trial the first 68 Ga-folate PET radiotracer ([ 68 Ga]Ga-EC2115) is tested to evaluate the possibility of differentiating COPD (chronic obstructive pulmonary disease) patients from control subjects and determine whether PET signal correlates with measurements of inflammation, disease severity, and rate of disease progression [16]. Currently, data on several folic acid based radiopharmaceuticals with PET-radionuclides, such as 18 F, 68/66 Ga, 152 Tb, 64 Cu, 55 Co and 44 Sc have been presented and even more new conjugates are under development [17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Properties of 68Ga-labelled Folic Acid Conjugates: Improvement Using HEHE Tag

et al. 2020

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The folate receptor (FR) is a promising cell membrane-associated target for molecular imaging and radionuclide therapy of cancer (FR-α) and potentially also inflammatory diseases (FR-β) through use of folic acid-based radioconjugate. FR is often overexpressed by cells of epithelial tumors, including tumors of ovary, cervix, endometrium, lungs, kidneys, etc. In healthy tissues, FR can be found in small numbers by the epithelial cells, mainly in the kidneys. Extremely high undesired accumulation of the folate radioconjugates in the renal tissue is a main drawback of FR-targeting concept. In the course of this work, we aimed to reduce the undesirable accumulation of folate radioconjugates in the kidneys by introducing a histidine/glutamic acid tag into their structure. Two folic acid based compounds were synthesized: NODAGA-1,4-butanediamine-folic acid (FA-I, as control) and NODAGA-[Lys-(HE)2]-folic acid (FA-II) which contains a (His-Glu)2 fragment. In vitro studies with FR (+) cells (KB and others) showed that both compounds have specificity for FR. Introduction of (HE)2-tag does not affect FR binding ability of the conjugates. In vivo biodistribution studies with normal laboratory animals, as well as with KB tumor bearing animals, were carried out. The results showed that introduction of the (HE)2 tag into the structure of folate radioconjugates can significantly reduce the accumulation of these compounds in non-target tissues and important organs (the accumulation in the kidneys is reduced 2–4 times), leaving the accumulation in tumor at least at the same level, and even increasing it.

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Determination of ionic 68Ga impurity in radiopharmaceuticals: major revision of radio-HPLC methods

Maruk

Ларенков

2019

J Radioanal Nucl Chem

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Preparation of highly purified 68Ga solutions via ion exchange in hydrochloric acid–ethanol mixtures

Cited by 9 publications

References 28 publications

Separation of Scandium from Hydrochloric Acid–Ethanol Leachate of Bauxite Residue by a Supported Ionic Liquid Phase

Separation of Scandium from Hydrochloric Acid–Ethanol Leachate of Bauxite Residue by a Supported Ionic Liquid Phase

Pharmacokinetic Properties of 68Ga-labelled Folic Acid Conjugates: Improvement Using HEHE Tag

Determination of ionic 68Ga impurity in radiopharmaceuticals: major revision of radio-HPLC methods

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