Preparation of Cuprous Oxide Mesoporous Spheres with Different Pore Sizes for Non-Enzymatic Glucose Detection

Abstract

Mass transfer plays a significant role in a sensor’s performance, because the substrate can be detected only when it contacts with the active catalytic surface. In this work, cuprous oxide mesoporous nanospheres (Cu2O MPNS) with different pore size distributions are fabricated and applied as electrocatalysts for glucose detection. The small pore Cu2O (SP-Cu2O, mean pore size of 5.3 nm) and large pore Cu2O (LP-Cu2O, mean pore size of 16.4 nm) spheres are prepared by the template method and an etching treatment. The obtained two kinds of Cu2O MPNS exhibit high porosity with a similar specific surface area of 61.2 and 63.4 (m2·g−1), respectively. The prepared Cu2O MPNS are used to construct an electrochemical non-enzymatic glucose sensor. The results show that the LP-Cu2O exhibits better performance than SP-Cu2O, which illustrates that the internal diffusion takes a great impact on the performance of the sensor. The LP-Cu2O modified electrode possesses a high and reproducible sensitivity of 2116.9 μA mM−1·cm−2 at the applied potential of 0.6 V with a wide detection range of 0.003–7.8 mM and a low detection limit of 0.42 μM.

Comprehensive Review on Current Interventions, Diagnostics, and Nanotechnology Perspectives against SARS-CoV-2

“…It facilitates the targeted sensing, multiple analyte detection, ability to mass transfer at short distances for fast response, etc. 8 This leads to high sensitivity, selectivity, and accelerated development of POC devices. Plasmonic nanoparticles, such as silver, gold, and other metal oxide nanoparticles, quantum dots, and graphene have gained significant interest in the field of biosensors ( Figure 8 ).…”

Mesoporous Materials–Based Electrochemical Biosensors from Enzymatic to Nonenzymatic

“…This work further pronounced the effect of pore size on the detection performance. [54] Inspired by the concept of ZrO 2 showed specific affinity to phosphate groups, Huo et al synthesized highly crystallized mesoporous ZrO 2 nanomaterials through solvent evaporation induced self-assembly approach to construct nonenzyme electrochemical sensor for selective detection of methyl parathion. The obtained materials showed the uniform pore size (≈6 nm) and highly crystallized framework by using F127 as the pore agent, and the quantitative analysis result showed the voltammetric currents were linear with concentrations of MP ranging from 1 ng mL −1 to 2 mg mL −1 with a detection limit of 0.53 ng mL −1 .…”

Cu 2 O hollow microspheres as electrode materials for non‐enzymatic electrochemical detection of glucose

“…Cu 2 O is an important p‐type semiconductor with a bandgap of 2.17 eV, and has attracted much attention due to its ultra‐low potential for electron transfer, higher exciton binding energy, non‐toxicity, and low price [8, 9]. Therefore, varieties of Cu 2 O nanostructure, including hollow nanocubes [10], nanowires [11], nanospheres [12], polyhedrons [13] were synthesised and investigated to improve the electrochemical activities in glucose sensing. It is noted that the hollow or porous Cu 2 O has more exposed sites and more channels to facilitate glucose diffusion and electron transfer [8].…”