Preparation of Cefquinome Nanoparticles by Using the Supercritical Antisolvent Process

Xiao, Kefeng; Wang, Weiqiang; Hu, Dedong; Hao, Zhihui; Qu, Yi-Qing; Liu, Yan

doi:10.1155/2015/767945

Cited by 8 publications

(6 citation statements)

References 18 publications

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“…It confirmed that the -carotene that dissolved in DCM solvent was not change after recrystallization process by SCCO2. Like the particle formation from other chemical compounds by SCCO2 antisolvent [24][25][26], the particles formation from -carotene solution by SCCO2 antisolvent may be affected by the feed solution concentration of -carotene injected in the SCCO2 antisolvent apparatus system. Fig.…”

Section: Resultsmentioning

confidence: 99%

Crystallization of All Trans–b–carotene by Supercritical Carbon Dioxide Antisolvent via Co–axial Nozzle

Kodama¹,

Honda²,

Machmudah³

et al. 2018

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The crystallization of -carotene through supercritical antisolvent process with carbon dioxide (CO2) as an antisolvent has been demonstrated. The experiments were conducted at temperatures of 40-60 o C and pressures of 10-14 MPa at a constant CO2 flow rate. As a starting material, -carotene powder was dissolved in dichloromethane (DCM). Results of UV-vis spectrophotometry and GC-MS analysis showed that there was no remaining DCM solvent in the -carotene particles products. It showed that CO2 has successfully removed DCM from -carotene particles products. The product characterization by using fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) showed that the CO2 solvent did not impregnate to the -carotene particles products. Results from scanning electron microscope (SEM) images showed that the -carotene particles products were successfully prepared in plate-like shape morphologies with size around 1 m.

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Section: Resultsmentioning

confidence: 99%

Crystallization of All Trans–b–carotene by Supercritical Carbon Dioxide Antisolvent via Co–axial Nozzle

Kodama¹,

Honda²,

Machmudah³

et al. 2018

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“…The flow diagram was shown in Figure 1. The detail operating process was described in our previous work [18]. In brief, carbon dioxide was purified and liquefied firstly and continuously introduced into the precipitation tank through an annular gap nozzle.…”

Section: Equipment and Operatingmentioning

confidence: 99%

“…Cefquinome concentration, feeding speed of solution, precipitation pressure, and temperature were selected as the factors of the experiment, and the level range of each factor was determined as shown in Table 1. All of these were selected based on the results of preliminary experiments and related study [18,19,21]. The median diameter ( 50 ) of particles acted as the dependent variable changing with these factors.…”

Section: Equipment and Operatingmentioning

confidence: 99%

“…Many nozzles have been applied in SEDS process, such as coaxial nozzles [15], internal twin-fluid mixing nozzles [16], jet-swirl nozzle [17], four-pinhole nozzle [18], prefilming nozzle [19], and annulus gap nozzle [20]. We have studied preparing cefquinome particles in SEDS process by using four-pinhole nozzle and obtained controlled size submicron particles [18]. However, there still existed some problems such as easy to block and small processing capacity.…”

Section: Introductionmentioning

confidence: 99%

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Cefquinome Controlled Size Submicron Particles Precipitation by SEDS Process Using Annular Gap Nozzle

Xiao

Wang

et al. 2017

International Journal of Chemical Engineering

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An annular gap nozzle was applied in solution enhanced dispersion by supercritical fluids (SEDS) process to prepare cefquinome controlled size submicron particles so as to enhance their efficacy. Analysis results of orthogonal experiments indicated that the concentration of solution was the primary factor to affect particle sizes in SEDS process, and feeding speed of solution, precipitation pressure, and precipitation temperature ranked second to fourth. Meanwhile, the optimal operating conditions were that solution concentration was 100 mg/mL, feeding speed was 9 mL/min, precipitation pressure was 10 MPa, and precipitation temperature was 316 K. The confirmatory experiment showed that D50 of processed cefquinome particles in optimal operating conditions was 0.73 μm. Moreover, univariate effect analysis showed that the cefquinome particle size increased with the increase of concentration of the solution or precipitation pressure but decreased with the increase of solution feeding speed. When precipitation temperature increased, the cefquinome particle size showed highest point. Moreover, characterization of processed cefquinome particles was analyzed by SEM, FT-IR, and XRD. Analysis results indicated that the surface appearance of processed cefquinome particles was flakes. The chemical structure of processed cefquinome particles was not changed, and the crystallinity of processed cefquinome particles was a little lower than that of raw cefquinome particles.

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“…Targeted drug delivery increases the drug quantity at the target site while simultaneously decreasing the systemic load to other body regions. Alternative dosage forms that provide this capacity include liposomes and nanoparticles (Fu et al, 2013 ; Kefeng et al, 2015 ). Lung-targeted drug delivery systems can deliver drug to the lung via inhalation or intravenous administration (Villara et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Preparation and testing of cefquinome-loaded poly lactic-co-glycolic acid microspheres for lung targeting

Zhao

Zhu

et al. 2017

Drug Delivery

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The aim of this study was to prepare cefquinome-loaded poly lactic-co-glycolic acid (PLGA) microspheres and to evaluate their in vitro and in vivo characteristics. Microspheres were prepared using a spry drier and were characterized in terms of morphology, size, drug-loading coefficient, encapsulation ratio and in vitro release. The prepared microspheres were spherical with smooth surfaces and uniform size (12.4 ± 1.2 μm). The encapsulation efficiency and drug loading of cefquinome was 91.6 ± 2.6 and 18.3 ± 1.3%, respectively. In vitro release of cefquinome from the microspheres was sustained for 36 h. In vivo studies identified the lung as the target tissue and the region of maximum cefquinome release. A partial lung inflammation was observed but disappeared spontaneously as the microspheres were removed through in vivo decay. The sustained cefquinome release from the microspheres revealed its applicability as a drug delivery system that minimized exposure to healthy tissues while increasing the accumulation of therapeutic drug at the target site. These results indicated that the spray-drying method of loading cefquinome into PLGA microspheres is a straightforward method for lung targeting in animals.

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Preparation of Cefquinome Nanoparticles by Using the Supercritical Antisolvent Process

Cited by 8 publications

References 18 publications

Crystallization of All Trans–b–carotene by Supercritical Carbon Dioxide Antisolvent via Co–axial Nozzle

Crystallization of All Trans–b–carotene by Supercritical Carbon Dioxide Antisolvent via Co–axial Nozzle

Cefquinome Controlled Size Submicron Particles Precipitation by SEDS Process Using Annular Gap Nozzle

Preparation and testing of cefquinome-loaded poly lactic-co-glycolic acid microspheres for lung targeting

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