Preparation of bioactive interferon alpha&amp;ndash; loaded polysaccharide nanoparticles using a new approach of temperature-induced water phase/water-phase emulsion

Guang, Liu; Xü, Dong; Jiang, Mier; Yuan, Weien

doi:10.2147/ijn.s35502

Cited by 3 publications

(1 citation statement)

References 45 publications

(42 reference statements)

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“…Liu and partners 76 explored a technique to get IFNα-stacked nanoparticles good for the conservation of IFNα-2b biological functionality and integrity .The antiviral movement of the polysaccharide nanoparticles was demonstrated to be exceptionally saved (above 97%) both in vitro and in vivo. Li and colleagues encapsulated IFN-α into SLNs utilizing the double emulsion solvent evaporation strategy.…”

Section: Nanoparticle As a Carrier For Hcv Vaccinementioning

confidence: 99%

A Critical Review on Nanoscience Advancement: In Treatment of Viral Infection

Chaudhary¹,

Parihar

Sharma

2021

J. Drug Delivery Ther.

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Viral contaminations speak to a general medical issue and one of the main sources of worldwide mortality. A large portion of the antiviral medications have low permeability, low dissolvability and other related physical properties which make them less efficient for the antiviral treatment. To conquer these constraints, different nanomedicine stages have been planned. Nanomaterials offer special physico-chemical properties that have various advantages for medicate conveyance as perfect devices for viral treatment. This review focuses on the currently used medicines used in viral infection, presents a broad overview of the application of nanosized materials for the treatment of common viral infections and shed light on the potential of nanotechnology to provide more effective treatment for HIV, Herpes simplex virus, Influenza virus and Hepatitis C virus. The action of antiviral medications could be improved with nanomedicine formulations. As the physicochemical properties of nanocarriers can empower their capacity to target the specific sites. When it comes to structuring nanocarriers, size is the most important factor and the nanoparticles can permit the controlled delivery kinetics, enhanced bioavailability, altered pharmacokinetics, and less side effects. Nanocarriers that build them appealing candidates for antiviral drug such as Improves bioavailability of the encapsulated actives, controlled release, reduce the toxicity associated with the anti-viral drugs. One of the important physicochemical properties mainly size is the most important design factor for nanocarriers for anti-viral drug delivery to the specific sites. Nanobased drug delivery also leads to enhance the potential of currently approved antiviral drugs. Keywords: Nanotechnology, HIV, Hepatits virus, Influenza, HSV

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Section: Nanoparticle As a Carrier For Hcv Vaccinementioning

confidence: 99%

A Critical Review on Nanoscience Advancement: In Treatment of Viral Infection

Chaudhary¹,

Parihar

Sharma

2021

J. Drug Delivery Ther.

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pH-sensitive degradable nanoparticles for highly efficient intracellular delivery of exogenous protein

Xu¹,

Wu²,

Chen³

et al. 2013

IJN

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Delivery of Proapoptotic Agents in Glioma Cell Lines by TSPO Ligand–Dextran Nanogels

Lopalco

Cutrignelli

Denora

et al. 2018

IJMS

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Translocator protein 18-kDa (TSPO) is a versatile mitochondrial target for molecular imaging and therapy. Moreover, selective TSPO ligands have been widely investigated for diagnostic purposes and explored to target drug delivery systems directed to cancer cells overexpressing TSPO. Indeed, poly(d,l-lactic-co-glycolic acid (PLGA) polymers and nanocarriers decorated with TSPO ligands are capable of transporting TSPO ligands inside cancer cells, inducing survival inhibition in cancer cells and producing mitochondrial morphology modification. The aim of this work was to prepare nanogels (NGs) made with TSPO ligand dextran conjugates (TSPO-Dex) that are useful as potential delivery systems of two TSPO ligands as apoptotic agents. Synthesis and complete characterization of TSPO–dextran conjugates, an average molecular weights analysis, TSPO ligand release profiles, thermal behaviour and swelling studies were achieved. NG preparation, characterization and in vitro biological studies were also performed. The release of TSPO ligands released from dextran conjugates at 37 °C occurred in human serum at a faster rate than that detected in phosphate buffer. Cytotoxicity studies demonstrated that NGs produced from TSPO ligand–dextran conjugates induce survival inhibition in rat C6 glioma cell lines. Cellular uptake was also proven by fluorescence microscopy.

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Preparation of bioactive interferon alpha– loaded polysaccharide nanoparticles using a new approach of temperature-induced water phase/water-phase emulsion

Cited by 3 publications

References 45 publications

A Critical Review on Nanoscience Advancement: In Treatment of Viral Infection

A Critical Review on Nanoscience Advancement: In Treatment of Viral Infection

pH-sensitive degradable nanoparticles for highly efficient intracellular delivery of exogenous protein

Delivery of Proapoptotic Agents in Glioma Cell Lines by TSPO Ligand–Dextran Nanogels

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