Preparation of an easy and low-cost electrochemical sensor for cysteine detection based on over-oxidized poly (thiophene) modified gold electrode

Ermiş, Nihal

doi:10.1007/s11696-021-01751-3

Cited by 3 publications

(2 citation statements)

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“…2 Importantly, cysteine possesses strong reducing capacity due to its active amino and carboxyl groups, making it susceptible to oxidation by oxygen gas. 3 Additionally, cysteine serves various physiological functions, for example, the prevention and treatment of radioactive hazard, 4 maintenance of sulfhydrase activity in the skin, treatment of skin diseases, [5][6][7] detoxication, 8 and so forth. These properties make cysteine applicable in diverse fields, such as: food, 9 cosmetics, 10 biochemical studies, 11 and so on.…”

Section: Introductionmentioning

confidence: 99%

“…The formation of disulfide bonds from free mercaptan is crucial for maintaining the structure and function of numerous proteins 2 . Importantly, cysteine possesses strong reducing capacity due to its active amino and carboxyl groups, making it susceptible to oxidation by oxygen gas 3 . Additionally, cysteine serves various physiological functions, for example, the prevention and treatment of radioactive hazard, 4 maintenance of sulfhydrase activity in the skin, treatment of skin diseases, 5–7 detoxication, 8 and so forth.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of hyaluronic acid‐based nanoparticles and studies on their radical scavenging activity

Zhu,

Xu,

Shang

et al. 2024

Polymers for Advanced Techs

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The purpose of this paper is to study the stability, radical scavenging activities, and bio‐safety of cysteine‐conjugated hyaluronic acid nanoparticles (Cys‐conj‐HA NPs). Additionally, the feasibility of utilizing these NPs as drug delivery systems is discussed. The structures of synthesized Cys‐conj‐HA polymers were analyzed using 1H nuclear magnetic spectrum (1H NMR) and Fourier transform infrared spectroscopy (FTIR) spectra. The stability, radical scavenging activity, and bio‐safety of fabricated Cys‐conj‐HA NPs were investigated. Transmission electron microscopy (TEM) photograph illustrated that Cys‐conj‐HA NPs possessed spherical shapes with an average diameter of approximately 230 nm. Furthermore, these NPs exhibited high stability at temperatures of 4, 25, and 37°C. Notably, Cys‐conj‐HA NPs demonstrated significant free radical scavenging capabilities. The high cell viability observed indicated the absence of cytotoxicity from Cys‐conj‐HA NPs. Additionally, bio‐safety studies revealed that these NPs did not induce acute toxicity in the blood and viscera of cargo‐free NPs treated mice. Elisa assays indicated that there was no significant difference in the concentrations of interferon‐γ (INF‐γ) and tumor necrosis factor‐α (TNF‐α) between Cys‐conj‐HA NPs and normal saline (NS) treated mice (ns, p > 0.05), suggesting the absence of an inflammatory reaction caused by these NPs. Consequently, it can be concluded that Cys‐conj‐HA NPs are sufficiently safe to be employed as a vehicle for delivering oxidizing drugs.

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