Preparation of a bioactive and degradable poly(ε-caprolactone)/silica hybrid through a sol–gel method

Rhee, Sang-Hoon; Choi, Je‐Yong; Kim, Hyun‐Man

doi:10.1016/s0142-9612(02)00251-x

Cited by 125 publications

(118 citation statements)

References 17 publications

Supporting

Mentioning

115

Contrasting

Unclassified

Order By: Relevance

“…Several years later, Rhee et al incorporated calcium (CaCl2) in the system, with the aim of improving the hybrids' bioactivity [147][148][149]. This was a very interesting idea, as calcium ions (Ca…”

Section: Hybrids Class IImentioning

confidence: 99%

Hybrid Organic-Inorganic Scaffolding Biomaterials for Regenerative Therapies

Sachot¹,

Engel²,

Castaño

2014

COC

View full text Add to dashboard Cite

Abstract:The introduction of hybrid materials in regenerative medicine has solved some problems related to the mechanical and bioactive properties of biomaterials. Calcium phosphates and their derivatives have provided the basis for inorganic components, thanks to their good bioactivity, especially in bone regeneration. When mixed with biodegradable polymers, the result is a synergic association that mimics the composition of many tissues of the human body and, additionally, exhibits suitable mechanical properties. Together with the development of nanotechnology and new synthesis methods, hybrids offer a promising option for the development of a third or fourth generation of smart biomaterials and scaffolds to guide the regeneration of natural tissues, with an optimum efficiency/cost ratio. Their potential bioactivity, as well as other valuable features of hybrids, open promising new pathways for their usein bone regeneration and other tissue repair therapies. This review provides a comprehensive overview of the different hybrid organic-inorganic scaffolding bio-materials developed so far for regenerative therapies, especially in bone. It also looks at the potential for research into hybrid materials for other, softer tissues, which is still at an initial stage, but with very promising results.

show abstract

Section: Hybrids Class IImentioning

confidence: 99%

Hybrid Organic-Inorganic Scaffolding Biomaterials for Regenerative Therapies

Sachot¹,

Engel²,

Castaño

2014

COC

View full text Add to dashboard Cite

show abstract

“…Polymers that have been hybridized with this purpose include poly(ε-caprolactone) [103][104][105][106] , poly(2-hydroxyethyl methacrylate) [89][90][91][107][108][109][110][111][112] , poly(2-hydroxyethyl acrylate) [113] , poly(methyl methacrylate) [92,114] , poly(butyl acrylate) [115] , poly(ethylene oxide) [116,117] , poly(ethylene oxide-co-epichlorhydrin) [118] , polyimide [119] , polyamide 6,6 [120] , poly(vinyl acetate) [121] , or poly(vinyl alcohol) [122] .…”

Section: Polymer/silica Nanohybrids Obtained By Sol-gel Processmentioning

confidence: 99%

“…Rhee et al [104,105] polymerized poly(ε-caprolactone) simultaneously via sol-gel with tetraethyl orthosilicate (TEOS) as silica precursor and calcium nitrate tetrahydrate to dope the nanohybrid with calcium ions. They characterized the HAp layer formed in a bioactivity test by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and inductively coupled plasma atomic emission spectroscopy (ICP-AES).…”

Section: Polymer/silica Nanohybrids Obtained By Sol-gel Processmentioning

confidence: 99%

“…The resulting spectra after this substraction have been depicted in the 1400-600 cm -1 range in Figure 3.3. The peaks appearing at 1060-1100 and 800 cm -1 are attributed to the Si-O-Si asymmetric and symmetric stretching vibration, respectively, and the peak at 950 cm -1 is characteristic of the Si-OH stretching vibration of the silica phase [90,91,104,108,109,111,122,143] . Their intensities increase proportionally to the silica content.…”

Section: X-ray Diffraction (Xrd)mentioning

confidence: 99%

“…hybrids, the intensity of the peaks at 1060-1100 and 950 cm -1 attributed to Si-O-Si and Si-OH bonds of the silica phase, respectively [90,104,108,109,112,122,145] , decrease with the immersion time in SBF, until FTIR cannot detect the original surface. It occurs similarly with the rest of the hybrids.…”

Section: Fourier-transform Infrared Analysismentioning

confidence: 99%

See 2 more Smart Citations

P(EMA-co-HEA)/SiO2 hybrid nanocomposites for guided dentin tissue regeneration: structure, characterization and bioactivity.

Vallés-Lluch¹

View full text Add to dashboard Cite

show abstract

Composite Scaffolds for Bone Tissue Regeneration

Navarro

Planell

2012

Wiley Encyclopedia of Composites

View full text Add to dashboard Cite

Bone is a composite material that combines both organic and inorganic phases into a complex structure with extraordinary mechanical properties. Numerous synthetic systems have been developed and are under investigation to create composites for the fabrication of both fixation devices and templates for the repair and regeneration of bone tissue. In the case of tissue engineering, the development of new scaffolds able to support and stimulate cell ingrowth and differentiation is of main importance. In this context, parameters such as the material nature, its physical and chemical properties as well as the structural and morphological properties of the 3D constructs are of paramount importance for the successful outcome of the scaffold‐based tissue engineering approach. A wide range of natural and synthetic polymers as well as numerous fabrication techniques have been used in the development of new 3D scaffolds for the regeneration of bone tissue. In this article, a comprehensive overview of the different materials and methods used for the elaboration of these structures is given as well as a thorough description of the role and relevance of the surface properties of materials and their implications in the biological response.

show abstract

Preparation of a bioactive and degradable poly(ε-caprolactone)/silica hybrid through a sol–gel method

Cited by 125 publications

References 17 publications

Hybrid Organic-Inorganic Scaffolding Biomaterials for Regenerative Therapies

Hybrid Organic-Inorganic Scaffolding Biomaterials for Regenerative Therapies

P(EMA-co-HEA)/SiO2 hybrid nanocomposites for guided dentin tissue regeneration: structure, characterization and bioactivity.

Composite Scaffolds for Bone Tissue Regeneration

Contact Info

Product

Resources

About