Preparation, &lt;I&gt;In Vitro&lt;/I&gt; and &lt;I&gt;In Vivo&lt;/I&gt; Evaluation of Budesonide Loaded Core/Shell Nanofibers as Oral Colonic Drug Delivery System

Xu, Qian; Zhang, Niping; Qin, Wei; Liu, Jingjing; Jia, Zhangjun; Liu, Hongxiang

doi:10.1166/jnn.2013.6920

Cited by 29 publications

(11 citation statements)

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“…85 Although co-axial electrospun nanofibers gained huge interest as gene-and growth factor-delivery systems, other types of therapeutic agents, such as antibiotics, antioxidant drugs or steroids have also been loaded into co-axially electrospun nanofibers for different applications. [86][87][88][89] For example, He et al 86 reported on the fabrication of tetracycline loaded poly(L-lactic acid) (PLA) nanofibers through the use of co-axial electrospinning. They showed that fiber diameters could be controlled by adjusting the concentration of the shell solution which, in turn influenced the release behavior.…”

Section: Co-axial Electrospinningmentioning

confidence: 99%

Drug Loading and Release from Electrospun Biodegradable Nanofibers

Goonoo¹,

Bhaw‐Luximon²,

Jhurry³

2014

j biomed nanotechnol

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This review explores the potential of electrospun nanofibers for drug delivery applications. In the first section, some of the key challenges in drug delivery as well as the promise of electrospun drug loaded nanofibers are highlighted. Techniques of drug incorporation into nanofibers such as blending, surface modification and co-axial electrospinning are detailed. The major requirements of drug eluting scaffolds such as biocompatibility and biodegradability, efficient drug control and release, and adequate mechanical performance are addressed. Drug release kinetics, biodegradability and mechanical properties can be controlled by careful selection of polymers and electrospinning processing parameters while biocompatibility of electrospun mats may be enhanced through surface modification of the nanofibers. The major applications as well as the routes of administration of the drug-loaded electrospun nanostructures are discussed. Currently available drug eluting nanofibrous mats for applications ranging from cancer therapy to wound dressings as well as their preclinical trials are also reviewed.

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Section: Co-axial Electrospinningmentioning

confidence: 99%

Drug Loading and Release from Electrospun Biodegradable Nanofibers

Goonoo¹,

Bhaw‐Luximon²,

Jhurry³

2014

j biomed nanotechnol

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“…10 Among these strategies, coaxial electrospun offers better drug stability, more complete drug encapsulation, and tighter control of release kinetics. Different kinds of drugs, [11][12][13][14][15][16][17][18] proteins, [19][20][21][22][23][24][25][26] glucocorticoids, 18 vitamins, 27 and genes 28 29 have been encapsulated in fibers by coaxial electrospinning for various biomedicine applications. In the field of blood-compatible materials, for example, Su et al fabricated core-shell poly(L-lactide-coepsilon-caprolactone) nanofibers with heparin incorporated by coaxial electrospinning.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Dipyridamole/Polyurethane Core–Shell Nanofibers by Coaxial Electrospinning for Controlled-Release Antiplatelet Application

Qin¹,

Liu²,

Zhao³

et al. 2016

j nanosci nanotechnol

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To improve the hemocompatibility of blood-compatible materials, antiplatelet drug dipyridamole (DIP) was encapsulated in polyurethane (PU) to form core-shell nanofibers by coaxial electrospinning method. PU solution and DIP/polycaprolactone compound solution served as shell and core fluid, respectively. Uniform fibers without beads, were fabricated and a clear core-shell structure was generated. The diameter of nanofibers and core structure increased with an increase in the flow rate of the core solution. X-Ray diffraction and differential scanning calorimeter showed that the whole system formed solid dispersion and DIP was dispersed in polymer matrix in an amorphous state. In vitro drug release test demonstrated that releasing curve had two phases consisting of initial burst release and sustained release governed by diffusion mechanism. A more flat curve occurred when the diameter of PU shell increased. In this case, the PU shell served as a barrier restricted DIP release from core drug reservoir. In vitro platelet adhesion test demonstrated that the DIP had maintained its antiplatelet effect after coaxial electrospinning process and could present distinguished antiplatelet activity after 7th and 30th days. Finally, DIP loaded core-shell nanofiber mats with good hemocompatibility, were conveniently fabricated by coaxial electrospinning, which has great potential in the field of tissue engineering vascular graft.

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“…Oral ingestion of drugs is the most prevalent form of drug delivery in the pharmaceutical industry. 81 Towards this end, Xu et al created and investigated a drug delivery system consisting of Budesonide (BUD) loaded core/shell nanofibers that follows the aforementioned oral colonic pathway. Coaxial electrospinning was performed to prepare Budesonide loaded ethylcellulose(EC)-core/ Euragit S100-shell nanofibers, shown in Figure 7 (b).…”

Section: Electrospinning Fiber Fabrication Technique In Drug Deliverymentioning

confidence: 99%

Fiber Based Approaches as Medicine Delivery Systems

Sharifi

Sooriyarachchi

Altural

et al. 2016

ACS Biomater. Sci. Eng.

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The goal of drug delivery is to ensure that therapeutic molecules reach the intended target organ or tissue, such that the effectiveness of the drug is maximized. The efficiency of a drug delivery system greatly depends on the choice of drug carrier. Recently, there has been growing interest in using micro-and nanofibers for this purpose. The reasons for this growing interest include these materials' high surface area to volume ratios, ease of fabrication, high mechanical properties, and desirable drug release profile. Here, we review developments in using these materials made by the most prevalent methods of fiber fabrication: electrospinning, microfluidics, wet spinning, rotary spinning, and self-assembly for drug delivery purposes. Additionally, we discuss the potential to use these fiber based systems in research and clinical applications.

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Preparation, <I>In Vitro</I> and <I>In Vivo</I> Evaluation of Budesonide Loaded Core/Shell Nanofibers as Oral Colonic Drug Delivery System

Cited by 29 publications

References 0 publications

Drug Loading and Release from Electrospun Biodegradable Nanofibers

Drug Loading and Release from Electrospun Biodegradable Nanofibers

Preparation of Dipyridamole/Polyurethane Core–Shell Nanofibers by Coaxial Electrospinning for Controlled-Release Antiplatelet Application

Fiber Based Approaches as Medicine Delivery Systems

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