Preparation, evaluation and functionalization of biomimetic block copolymer coatings for potential applications in cardiovascular implants

Li, Peichuang; Luo, Zhu; Li, Xin; Wang, Rui; Chen, Hang; Zhao, Yuancong; Wang, Jin; Huang, Nan

doi:10.1016/j.apsusc.2019.144085

Cited by 20 publications

(7 citation statements)

References 42 publications

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“…Blending of polymers can often produce materials with enhanced characteristics more rapidly compared to developing new polymer chemistry [1,2]. Extensive studies have been conducted on copolymers due to their high application potential [3][4][5][6][7][8] and their importance in basic science [9]. Developing new polymer blends with improved properties by mixing two or more polymers is usually a less time-consuming pro-cess than new polymer development with desired properties.…”

Section: Introductionmentioning

confidence: 99%

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

khoramabadi

Arefian

Hojjati

et al. 2020

jcc

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Polyvinyl alcohol/carboxymethyl cellulose (PVA/CMC) composites have attracted considerable attention due to the synergic relation between the two polymers and developing novel blends with improved properties. On one hand, PVA is a versatile polymer with higher mechanical properties compared to CMC. On the other hand, CMC has high biodegradability and biocompatibility, while suffering from poor mechanical properties. Therefore, the blending of the two polymers can help to benefit from the individual component properties. This paper has reviewed the properties and potential applications (e.g. drug delivery, food packaging, and agriculture) of the PVA/ CMC composites.

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Section: Introductionmentioning

confidence: 99%

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

khoramabadi

Arefian

Hojjati

et al. 2020

jcc

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“…Enzyme-linked immunosorbent assay was used in the tests of fibrinogen denaturation and adhesion of different samples [ 48 , 49 ]. First, 3 mg/ml of human fibrinogen solution and 42 mg/ml of BSA solution was obtained via PBS.…”

Section: Methodsmentioning

confidence: 99%

Preparation of phospholipid-based polycarbonate urethanes for potential applications of blood-contacting implants

Cai

et al. 2020

Regenerative Biomaterials

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Polyurethanes are widely used in interventional devices due to the excellent physicochemical property. However, non-specific adhesion and severe inflammatory response of ordinary polyurethanes may lead to severe complications of intravenous devices. Herein, a novel phospholipid-based polycarbonate urethanes (PCUs) were developed via two-step solution polymerization by direct synthesis based on functional raw materials. Furthermore, PCUs were coated on biomedical metal sheets to construct biomimetic anti-fouling surface. The results of stress–strain curves exhibited excellent tensile properties of PCUs films. Differential scanning calorimetry results indicated that the microphase separation of such PCUs polymers could be well regulated by adjusting the formulation of chain extender, leading to different biological response. In vitro blood compatibility tests including bovine serum albumin adsorption, fibrinogen adsorption and denaturation, platelet adhesion and whole-blood experiment showed superior performance in inhibition non-specific adhesion of PCUs samples. Endothelial cells and smooth muscle cells culture tests further revealed a good anti-cell adhesion ability. Finally, animal experiments including ex vivo blood circulation and subcutaneous inflammation animal experiments indicated a strong ability in anti-thrombosis and histocompatibility. These results high light the strong anti-adhesion property of phospholipid-based PCUs films, which may be applied to the blood-contacting implants such as intravenous catheter or antithrombotic surface in the future.

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“…[77][78][79][80] In this type of treatment, it is essential to reduce the adhesion of blood cells, which can induce thrombus formation and blood clogging. Copolymers of MPC and many kinds of other monomers via ATRP, 81 free radical polymerization, 70,77,78,82 and condensation reaction 83,84 etc., have been employed to obtain different structural architectures before coating on the cardiovascular devices allowing devices with an antifouling surface. A dip-coat approach with/without surface activation, 77,82,83,85 or further polymerization 79,86,87 are common methods used for the surface coating.…”

Section: Artificial Implantsmentioning

confidence: 99%

Recent progress and perspectives in applications of 2-methacryloyloxyethyl phosphorylcholine polymers in biodevices at small scales

Seetasang

2022

J. Mater. Chem. B

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Preparation, evaluation and functionalization of biomimetic block copolymer coatings for potential applications in cardiovascular implants

Cited by 20 publications

References 42 publications

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

Preparation of phospholipid-based polycarbonate urethanes for potential applications of blood-contacting implants

Recent progress and perspectives in applications of 2-methacryloyloxyethyl phosphorylcholine polymers in biodevices at small scales

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