Preparation, degradation and in vitro release of ciprofloxacin-eluting ureteral stents for potential antibacterial application

Ma, Xiaofei; Xiao, Yan; Xu, Heng; Lei, Kun; Lang, Meidong

doi:10.1016/j.msec.2016.04.072

Cited by 38 publications

(35 citation statements)

References 44 publications

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“…This, therefore, postpones wound healing and drug delivery . Furthermore, the polymers used in wound dressings should have the ability to load and release drugs in a controlled manner while they also have the same flexibility as the skin …”

Section: Introductionmentioning

confidence: 99%

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Preparation and evaluation of poly glycerol sebacate/poly hydroxy butyrate core‐shell electrospun nanofibers with sequentially release of ciprofloxacin and simvastatin in wound dressings

Heydari

Varshosaz

Kharazi

et al. 2018

Polymers for Advanced Techs

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Biodegradable wound dressing of poly glycerol sebacate/poly hydroxy butyrate was fabricated via the coaxial electrospinning process. Simvastatin and ciprofloxacin were loaded in the core and shell of the fibers, respectively. Scanning electron microscopy and transmission electron microscopy images showed a uniform core/shell structure. Introducing drugs into the polymers would cause the dressing samples to become more hydrophilic and degradation to occur faster. Drugs release would face no interventions, in which, approximately 60% of ciprofloxacin was released during the first 24 hours. Simvastatin exhibited a slower and controlled release behavior, with its release peak recorded after 2 days. The drug‐containing samples showed a proper bactericidal activity against both Gram‐positive and Gram‐negative bacteria. It may be concluded that the drug‐laden wound dressing fabricated in this study is capable of releasing the 2 drugs sequentially and that it is the ideal conditions for controlling infections and reducing wound healing duration.

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Section: Introductionmentioning

confidence: 99%

“…Ciprofloxacin released in the wound serves as an antibacterial agent. It is claimed to be effective on a wide range of infections caused by a large spectrum of gram‐positive and gram‐negative bacteria in both humans and animals …”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of poly glycerol sebacate/poly hydroxy butyrate core‐shell electrospun nanofibers with sequentially release of ciprofloxacin and simvastatin in wound dressings

Heydari

Varshosaz

Kharazi

et al. 2018

Polymers for Advanced Techs

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show abstract

“…The wide range of applications of bioresorbable polymers in medicine is primarily concerned with the possibility of shaping their mechanical and physicochemical properties. Controlled degradation of polymers allows them to be used as carriers of drug substances to provide drug dosing with the desired kinetics until the desired therapeutic effect is sciENcE aNd tEchNology reached [14]. These polymers have a confirmed biocompatibility [17] and their final degradation products in the form of lactic, glycolic and hydroxyhexanoic acids are inert to the body and metabolized in the Krebs cycle [16].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, it can support the process of treatment through local, controlled release of active substances. Local delivery of therapeutic substances will contribute to its effectiveness, while limiting the amount of while limiting the amount of used active substances compared to conventional pharmacotherapies [14,19].…”

Section: Introductionmentioning

confidence: 99%

Corrosion resistance of Ti6Al4V alloy coated with caprolactone-based biodegradable polymeric coatings

Kajzer¹,

Jaworska²,

Jelonek³

et al. 2018

Eksploatacja i Niezawodność – Maintenance and Reliability

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The aim of this study was to determine the influence of long-term exposure of Ringer’s solution on degradation of the anodically oxidated Ti6Al4V alloy coated with a biodegradable polymer coating. Polymeric coatings made of poly(glycolide-ε-caprolactone) – G-Cap and poly(glycolide- ε-caprolactone-lactide) – G-Cap-L were applied by a dip-coating method. Degradation was assessed on the basis of the results of pitting corrosion resistance and density of metal ions infiltrating to the solution. Studies were conducted for samples after 3, 6, 8, 10 and 12 weeks of exposure to the corrosive environment. In addition, topography of the surface of the polymer coating was assessed. As a result of potentiodynamic studies, the value of the polarization resistance and corrosion potential for the G-Cap and G-Cap-L coated samples were significantly decreased while simultaneous reduction of the density of metal ions infiltrating to the solution throughout the whole study period. There was also observed a faster degradation of the G-Cap coating compared to G-Cap-L, which showed local discontinuity after 12 weeks of exposure. The obtained results provide the basis for the development of polymeric coatings on surface of metal implants with predictable time / kinetics of degradation by selecting the composition of polymers while simultaneous limitation of metal ions infiltration into surrounding tissues.

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“…In addition to restrictions deriving from clinical and pharmacological requirements, the basic aspect of coating production still remains an open question and the optimization of coating techniques also depends on material properties. Common techniques for coating preparation are dipping, brushing, spraying or by ink‐jet printing . Regardless of the selected technique, bulk and chemicophysical properties of polymers and their solutions govern final results.…”

Section: Introductionmentioning

confidence: 99%

Adhesion properties of poly(methylmethacrylate‐co‐n‐butylmethacrylate) copolymers in stent coatings

Gagliardi

2019

J of Applied Polymer Sci

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This work explores the adhesion properties of polymer solutions and thin coatings obtained by different‐composition poly(methylmethacrylate‐co‐n‐butylmethacrylate) copolymers. Surface wettability, work of adhesion, and work of spreading are calculated for solutions. Increasing amounts of n‐butylmethacrylate lead to higher values of work of adhesion, measured over two stent‐like flat surfaces (AISI 316L and pyrolytic carbon). The same moiety induces the solution viscosity increase and the decrease of the work of spreading and allows obtaining more homogeneous coatings. Adhesion of thin coatings is tested in dry (cross‐cut test) and wet (immersion) conditions. Adhesion tests of coatings obtained by solvent casting reflect thermodynamic parameters evaluated for solutions. Coatings show better strength in cross‐cut tests and a prolonged adhesion in wet conditions by raising the n‐butylmethacrylate fraction. The same trends are confirmed in commercial devices. In conclusion, the study of thermodynamic solution/substrate interactions can explain coating properties. The proposed approach is worthwhile to improve deposition procedures based on polymer solutions. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47814.

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Preparation, degradation and in vitro release of ciprofloxacin-eluting ureteral stents for potential antibacterial application

Cited by 38 publications

References 44 publications

Preparation and evaluation of poly glycerol sebacate/poly hydroxy butyrate core‐shell electrospun nanofibers with sequentially release of ciprofloxacin and simvastatin in wound dressings

Preparation and evaluation of poly glycerol sebacate/poly hydroxy butyrate core‐shell electrospun nanofibers with sequentially release of ciprofloxacin and simvastatin in wound dressings

Corrosion resistance of Ti6Al4V alloy coated with caprolactone-based biodegradable polymeric coatings

Adhesion properties of poly(methylmethacrylate‐co‐n‐butylmethacrylate) copolymers in stent coatings

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