Various types of biodegradable polymers containing lactide, glycolide, caprolactone, and trimethylene carbonate units have been used to obtain ciprofloxacin (CFX)enriched coatings developed on the Ti6Al7Nb alloy, intended for short-term therapy.In the first step, the surface of the Ti6Al7Nb alloy was modified, mostly according to sandblasting and anodic oxidation to obtain the TiO 2 layer. Anodizing can be an effective method for preparing TiO 2 coatings with osteoconductive properties. The polymer containing CFX molecules was deposited on the modified alloy, and Polymer + CFX/TiO 2 /Ti6Al7Nb systems were developed. CFX-enriched coatings adhered well to the surface of the previously modified alloy. Polymer layers maintain the topography of the alloy due to the development of the surface during the sandblasting method. As polymers intended for the study possess degradation ability, they are capable of releasing the incorporated drug. Antibacterial activity of CFX-enriched coatings was examined to verify the functionality of designed Polymer + CFX/TiO 2 / Ti6Al7Nb systems, and the bactericidal effect was confirmed for all cases. The presented study is an extension of previous, initial research and creates an overview of polyester or polyestercarbonate CFX-eluting coatings.
K E Y W O R D Sciprofloxacin, drug delivery, implants, polyester, Ti6Al7Nb
The aim of this study was to determine the influence of long-term exposure of Ringer’s solution on degradation of the anodically
oxidated Ti6Al4V alloy coated with a biodegradable polymer coating. Polymeric coatings made of poly(glycolide-ε-caprolactone)
– G-Cap and poly(glycolide- ε-caprolactone-lactide) – G-Cap-L were applied by a dip-coating method. Degradation was assessed
on the basis of the results of pitting corrosion resistance and density of metal ions infiltrating to the solution. Studies were conducted for samples after 3, 6, 8, 10 and 12 weeks of exposure to the corrosive environment. In addition, topography of the surface
of the polymer coating was assessed. As a result of potentiodynamic studies, the value of the polarization resistance and corrosion
potential for the G-Cap and G-Cap-L coated samples were significantly decreased while simultaneous reduction of the density
of metal ions infiltrating to the solution throughout the whole study period. There was also observed a faster degradation of the
G-Cap coating compared to G-Cap-L, which showed local discontinuity after 12 weeks of exposure. The obtained results provide
the basis for the development of polymeric coatings on surface of metal implants with predictable time / kinetics of degradation by
selecting the composition of polymers while simultaneous limitation of metal ions infiltration into surrounding tissues.
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