Preparation, characterization, and study of the antimicrobial activity of a Hinokitiol-copper(II)/γ-cyclodextrin ternary complex

Suzuki, Rina; Inoue, Yutaka; Murata, Ikuo; Nomura, Harue; Isshiki, Yasunori; Hashimoto, Masashi; Kudo, Yotaro; Kitagishi, Hiroaki; Kondo, Seiichi; Kanamoto, Ikuo

doi:10.1016/j.molstruc.2019.05.078

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…Thus, hinokitiol shows low potential to induce resistance in some Candida species and greatly improves the survival of Candida-infected Galleria mellonella ( Jin et al, 2021 ). Furthermore, hinokitiol has also been demonstrated to yield prospective antibacterial effect with low or no negative effect on the human host or environment ( Suzuki et al, 2019 ).…”

Section: Role Of Terpenes and Terpenoids On Human Healthmentioning

confidence: 99%

Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives

et al. 2022

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Section: Role Of Terpenes and Terpenoids On Human Healthmentioning

confidence: 99%

Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives

et al. 2022

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“…Suzuki et al [27] showed that hinokitiol has polar groups allowing it to form metal complexes through coordinate bonds with metal ions. Increased antimicrobial activity was observed in hinokitiol, a metal ion (Cu (II)), and g-cyclodextrin (gCD) inclusion complex compared to hinokitiol alone.…”

Section: Antibacterial Effects and Mechanismsmentioning

confidence: 99%

Health Benefits and Pharmacological Properties of Hinokitiol

et al. 2021

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Hinokitiol is a natural bioactive compound found in several aromatic and medicinal plants. It is a terpenoid synthetized and secreted by different species as secondary metabolites. This volatile compound was tested and explored for its different biological properties. In this review, we report the pharmacological properties of hinokitiol by focusing mainly on its anticancer mechanisms. Indeed, it can block cell transformation at different levels by its action on the cell cycle, apoptosis, autophagy via inhibiting gene expression and dysregulating cellular signaling pathways. Moreover, hinokitiol also exhibits other pharmacological properties, including antidiabetic, anti-inflammatory, and antimicrobial effects. It showed multiple and several effects through its inhibition, interaction and/or activation of the main cellular targets inducing these pathologies.

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“…Cyclodextrins (CD), as cyclic polysaccharide containing D-glucopyranose units linked with α-1,4-glucosidic bonds, are classified as α, β or γ depending on the number of such units from their structure [ 108 ] Their ability to be functionalized and to retain complexes into their cavity was exploited in order to develop useful carriers. A hydrogel film composed of carboxymethyl cellulose (CMC), cellulose nanocrystals (CNC) and hydroxypropyl β cyclodextrin (HP-β-CD) cross-linked by citric acid was prepared and studied for the controlled release of the neohesperidin-copper(II) complex.…”

Section: Delivery Systems For Copper Active Complexesmentioning

confidence: 99%

Improvement in the Pharmacological Profile of Copper Biological Active Complexes by Their Incorporation into Organic or Inorganic Matrix

2020

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Every year, more Cu(II) complexes are proven to be biologically active species, but very few are developed as drugs or entered in clinical trials. This is due to their poor water solubility and lipophilicity, low stability as well as in vivo inactivation. The possibility to improve their pharmacological and/or oral administration profile by incorporation into inorganic or organic matrix was studied. Most of them are either physically encapsulated or conjugated to the matrix via a moiety able to coordinate Cu(II). As a result, a large variety of species were developed as delivery carriers. The organic carriers include liposomes, synthetic or natural polymers or dendrimers, while the inorganic ones are based on carbon nanotubes, hydrotalcite and silica. Some hybrid organic-inorganic materials based on alginate-carbonate, gold-PEG and magnetic mesoporous silica-Schiff base were also developed for this purpose.

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Preparation, characterization, and study of the antimicrobial activity of a Hinokitiol-copper(II)/γ-cyclodextrin ternary complex

Cited by 8 publications

References 32 publications

Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives

Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives

Health Benefits and Pharmacological Properties of Hinokitiol

Improvement in the Pharmacological Profile of Copper Biological Active Complexes by Their Incorporation into Organic or Inorganic Matrix

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