Preparation, characterization and physicochemical properties of DOPE-PEG2000 stabilized oleic acid-soy lecithin liposomes (POLL)

Suk, Vicit Rizal Eh; Misran, Misni

doi:10.1016/j.colsurfa.2016.10.053

Cited by 7 publications

(7 citation statements)

References 34 publications

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“…This typical behavior is attributed to the small vesicle size and high surface energy, which entails larger van der Waals attraction forces, thus, promoting high attraction among nanoliposomes (Dahman, 2017 ). Several research groups have been proposed alternatives to overcome these issues, such as the addition of surfactants or polyols to stabilize the nano liposomal suspensions (Mortazavi et al, 2007 ; Ebrahimifar et al, 2017 ; Eh Suk and Misran, 2017 ).…”

Section: Limitations Research Gaps and Challengesmentioning

confidence: 99%

Insight Into Nanoliposomes as Smart Nanocarriers for Greening the Twenty-First Century Biomedical Settings

Aguilar-Pérez

Avilés-Castrillo

Medina

et al. 2020

Front. Bioeng. Biotechnol.

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The necessity to develop more efficient, biocompatible, patient compliance, and safer treatments in biomedical settings is receiving special attention using nanotechnology as a potential platform to design new drug delivery systems (DDS). Despite the broad range of nanocarrier systems in drug delivery, lack of biocompatibility, poor penetration, low entrapment efficiency, and toxicity are significant challenges that remain to address. Such practices are even more demanding when bioactive agents are intended to be loaded on a nanocarrier system, especially for topical treatment purposes. For the aforesaid reasons, the search for more efficient nano-vesicular systems, such as nanoliposomes, with a high biocompatibility index and controlled releases has increased considerably in the past few decades. Owing to the stratum corneum layer barrier of the skin, the in-practice conventional/conformist drug delivery methods are inefficient, and the effect of the administered therapeutic cues is limited. The current advancement at the nanoscale has transformed the drug delivery sector. Nanoliposomes, as robust nanocarriers, are becoming popular for biomedical applications because of safety, patient compliance, and quick action. Herein, we reviewed state-of-the-art nanoliposomes as a smart and sophisticated drug delivery approach. Following a brief introduction, the drug delivery mechanism of nanoliposomes is discussed with suitable examples for the treatment of numerous diseases with a brief emphasis on fungal infections. The latter half of the work is focused on the applied perspective and clinical translation of nanoliposomes. Furthermore, a detailed overview of clinical applications and future perspectives has been included in this review.

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Section: Limitations Research Gaps and Challengesmentioning

confidence: 99%

Insight Into Nanoliposomes as Smart Nanocarriers for Greening the Twenty-First Century Biomedical Settings

Aguilar-Pérez

Avilés-Castrillo

Medina

et al. 2020

Front. Bioeng. Biotechnol.

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show abstract

“…It should be emphasized that in our system, the drug remains encapsulated and is incorporated by the cell more efficiently, enhancing the cytotoxic effect of the treatment. Furthermore, the result of comparing the effect of the free drug with the encapsulated drug is very important, as it adds an additional advantage to our system compared to other nanocarriers studied by other authors, where this comparison is not made. ,,, …”

Section: Discussionmentioning

confidence: 99%

“…Eh Suk et al effectively encapsulated 5-FU within echogenic crude soy lecithin liposomes using the thin film hydration method followed by extrusion. The resulting liposomes exhibited spherical morphology and nanoscale dimensions.…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that soy lecithin vesicles (SLVs) have antioxidant properties, defined and uniform sizes, high encapsulation capacity, and excellent physical stability against the digestive process. Furthermore, it has also been determined that the encapsulation of analytes does not affect the polydispersity or the size of these vesicles. ,− …”

Section: Introductionmentioning

confidence: 99%

“…This is the case of soy lecithin (SL), which is a mixture of phospholipids with an amphiphilic nature, which, in the presence of water, can form vesicles. 35,42 Eh Suk et al 43 effectively encapsulated 5-FU within echogenic crude soy lecithin liposomes using the thin film hydration method followed by extrusion. The resulting liposomes exhibited spherical morphology and nanoscale dimensions.…”

Section: ■ Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles

Chamorro Cañon,

Luna,

Sabini

et al. 2024

J. Phys. Chem. B

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5-Fluorouracil (5-FU) is an antineoplastic agent known for its low bioavailability and limited cellular penetration, often resulting in adverse effects on healthy cells. Thus, finding vehicles that enhance bioavailability, enable controlled release, and mitigate adverse effects is crucial. The study focuses on encapsulating 5-FU within soy lecithin vesicles (SLVs) and assessing its impact on the carrier's properties and functionality. Results show that incorporating 5-FU does not affect SLVs' size or polydispersity, even postlyophilization. Liberation of 5-FU from SLVs requires system disruption rather than spontaneous release, with an encapsulation efficiency of approximately 43% determined using Square Wave Voltammetry. Cytotoxicity assays on colorectal cancer cells reveal SLV-based delivery's significant efficacy, surpassing free drug solution effects with 45% cell viability after 72 h vs 73% viability. The research addresses 5-FU's limited bioavailability by creating a biocompatible nanocarrier for efficient drug delivery, highlighting SLVs as promising for targeted cancer therapy due to sustained antiproliferative effects and improved cellular uptake. The study underscores the importance of tailored drug delivery systems in enhancing therapeutic outcomes and suggests SLV/5-FU formulations as a potential advancement in cancer treatment strategies.

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N-Stearoyl Chitosan as a Coating Material for Liposomes Encapsulating Itraconazole

et al. 2021

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Preparation, characterization and physicochemical properties of DOPE-PEG2000 stabilized oleic acid-soy lecithin liposomes (POLL)

Cited by 7 publications

References 34 publications

Insight Into Nanoliposomes as Smart Nanocarriers for Greening the Twenty-First Century Biomedical Settings

Insight Into Nanoliposomes as Smart Nanocarriers for Greening the Twenty-First Century Biomedical Settings

Electrochemical Characterization of the Encapsulation and Release of 5-Fluorouracil in Nanocarriers Formed from Soy Lecithin Vesicles

N-Stearoyl Chitosan as a Coating Material for Liposomes Encapsulating Itraconazole

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