Preparation, characterization, and in vitro diffusion study of nonwoven electrospun nanofiber of curcumin-loaded cellulose acetate phthalate polymer

The treatment of wounds is expensive and challenging. Most of the available wound dressings are not effective and suffer from limitations such as poor antimicrobial activity, toxicity, inability to provide suitable moisture to the wound and poor mechanical performance. The use of inappropriate wound dressings can result in a delayed wound healing process. Nanosize range scaffolds have triggered great attention because of their attractive properties, which include their capability to deliver bioactive agents, high surface area, improved mechanical properties, mimic the extracellular matrix (ECM), and high porosity. Nanofibrous materials can be further encapsulated/loaded with metal-based nanoparticles to enhance their therapeutic outcomes in wound healing applications. The widely studied metal-based nanoparticles, silver nanoparticles exhibit good properties such as outstanding antibacterial activity, display antioxidant, and anti-inflammatory properties, support cell growth, making it an essential bioactive agent in wound dressings. This review article reports the biological (in vivo and in vitro) and mechanical outcomes of nanofibrous scaffolds loaded with silver nanoparticles on wound healing.

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“…Some examples of nanofibrous scaffolds include nanofibrous mats, nanofibrous membranes, nanofibrous webs, nanofibrous patches, etc. [ 38 ].…”

Section: Electrospinning Technique and Properties Of Nanofibrous Materials As Wound Dressingsmentioning

confidence: 99%

Electrospun Nanofibers/Nanofibrous Scaffolds Loaded with Silver Nanoparticles as Effective Antibacterial Wound Dressing Materials

et al. 2021

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“…Ravikumar and co-workers formulated electrospun cellulose acetate phthalate polymer nanofibers loaded with curcumin. The swelling analysis demonstrated that the curcumin-loaded nanofibers and plain nanofibers revealed 400% swelling capacity between 1 and 12 h. The in vitro diffusion analysis showed a slow and sustained release of curcumin which is important for wound healing [ 118 ].…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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“…With regard to all of CEO/CD inclusion complexes, no aggregation of CEO/CD was seen at the surface of nanofibers and nanofibers were more uniform and bead-free. A broad range of diameter distribution of fibers is because of incorporation of CEO/CD inclusion complex in nanofibers [20][21][22].…”

Section: Morphology Of Pcl-based Nanofibers Containing Inclusion Compmentioning

confidence: 99%

“…Under sonic energy, higher amount of CEO encapsulated in CDs cavity so higher amount of CEO released from PCL nanofibers loaded with CEO/CD inclusion complexes. On the other hand, PCL nanofibers which were loaded with CEO/CD at room temperature showed larger diameter than PCL nanofibers which were loaded with CEO/CD under sonic energy [20][21][22]. Incorporation of CDs inclusion complexes with various compounds into nanofibers matrix could control release of guest molecules which is attractive way for designing fibrous materials with advanced applications such as drug delivery and tissue engineering [18][19][20].…”

Section: In Vitro Ceo Release From the Obtained Nanofibersmentioning

confidence: 99%

Poly(ε-caprolactone) electrospun nanofibers containing cinnamon essential oil nanocapsules: A promising technique for controlled release and high solubility

Amiri

Rahimi

2018

Journal of Industrial Textiles

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Nowadays, cinnamon essential oil is one of the most popular spices for food flavoring and also for medicinal uses such as anti-inflammation agent, but its low solubility, irritations, and allergic reactions limit its applications. To overcome these limitations, cinnamon essential oil-loaded nanocontainers were prepared via inclusion complexation between the cyclodextrins and cinnamon essential oil under two different conditions, i.e., at room temperature or under sonic energy. The resulting supramolecular nanocontainers were characterized by XRD, SEM, DSC, and FTIR. Successful insertion of cinnamon essential oil in the cyclodextrins’ cavity was confirmed by the significant differences between the FTIR, DSC, and XRD spectra of initial mixtures and those of the complexes. XRD results indicated that crystalline complexes adopted a mixture of head to head channel-type and cage conformation for cinnamon essential oil/cyclodextrins at various conditions. Solubility, bioavailability, and in vitro dissolution of obtained cinnamon essential oil nanocapsules were investigated, and results show that by encapsulation of cinnamon essential oil, solubility improved and its release is controllable. The solubility of cinnamon essential oil increased linearly as the concentration of cyclodextrins was increased, confirming the 1:1 stoichiometry of the complex. Electro-spun nanofibers of poly-ɛ-caprolactone containing cinnamon essential oil/cyclodextrins inclusion complex at various conditions indicated that these nanofibers did not show beading defect with controlled release of cinnamon essential oil.

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Preparation, characterization, and in vitro diffusion study of nonwoven electrospun nanofiber of curcumin-loaded cellulose acetate phthalate polymer

Cited by 54 publications

References 43 publications

Electrospun Nanofibers/Nanofibrous Scaffolds Loaded with Silver Nanoparticles as Effective Antibacterial Wound Dressing Materials

Electrospun Nanofibers/Nanofibrous Scaffolds Loaded with Silver Nanoparticles as Effective Antibacterial Wound Dressing Materials

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Poly(ε-caprolactone) electrospun nanofibers containing cinnamon essential oil nanocapsules: A promising technique for controlled release and high solubility

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