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Novel curcumin (CUR)-loaded cellulose acetate phthalate (CAP) nonwoven electrospun nanofiber (NF) transdermal mat was developed and evaluated for its CUR diffusion properties. Various CAP solutions from 5 to 20 wt% were tested; 17.5 wt% was found to be a suitable concentration for NF fabrication without defects, such as bubble or ribbon structures. The selected wt% CAP solution was loaded with CUR and electrospun into NFs. The prepared CUR-loaded NFs were characterized using scanning electron microscopy, X-ray diffraction, ultraviolet-visible spectroscopy, thermogravimetric analysis (TGA), and diffusion studies. The as-prepared fibers demonstrated controlled transdermal delivery of CUR for up to 24 h.

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To enhance the solubility of Repaglinide, we attempted to use Plasdone S 630, a novel solubility enhancer. Followed by the hot-melt extrusion method and made into a tablet dosage form. The prepared dosage forms subjected to all pre-compression and post-compression parameters evaluations. The data obtained from in-vitro drug release suggested that the trial-11 is the ideal formulation among all other formulations. The in-vitro release was also profiling around 95% within 45 minutes. The hardness of the prepared tablets was around 10-12 kg/cm 2 with the friability was less than 1%. So, this method could apply on the regular basis for formulating the tablet dosage forms.