Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams

Siqueira, Lilian de; Paula, Cynthia Guimarães de; Motisuke, Mariana; Gouveia, Rubia F.; Camargo, Samira Esteves Afonso; Milhan, Noala Vicensoto Moreira; Trichês, Eliandra de Sousa

doi:10.1590/1980-5373-mr-2016-0467

Cited by 10 publications

(4 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Gas foaming can be combined with sintering to prepare glass/ceramic dual-porosity scaffolds [187,[202][203][204][205][206][207][208][209][210][211][212] in two ways: 1) Sol-gel foaming, where a foaming step is added during the sol-gel synthesis of glass to create a macroporous glass scaffold, and the resulting scaffold is later subjected to sintering to create micropores. [211] 2) Gel-cast foaming, where a foaming agent is added to a slurry of glass or ceramic powder, is then combined with organic monomers along with dispersants and binders.…”

Section: Gas Foaming and Sinteringmentioning

confidence: 99%

Glass, Ceramic, Polymeric, and Composite Scaffolds with Multiscale Porosity for Bone Tissue Engineering

Jeyachandran

Cerruti

2023

Adv Eng Mater

View full text Add to dashboard Cite

Porosity affects performance of scaffolds for bone tissue engineering both in vitro and in vivo. Macropores (i.e., pores with a diameter >100 μm) are essential for cellular infiltration; micropores (i.e., pores with a diameter of 1–10 μm) promote cell adhesion and facilitate nutrient absorption. Scaffolds containing both macropores and micropores exploit the advantages of both pore sizes and have excellent osteogenic properties. Nanopores (i.e., pores with a diameter of 1–50 nm) can be included as well, to improve cell–material interactions by further enhancing the surface area of the scaffold. This article reviews fabrication techniques and properties of scaffolds with multiscale porosity, focusing on glass, ceramic, polymeric, and composite scaffolds. After discussing the structure of bone and how it inspired scaffolds for bone tissue engineering, pore nomenclature is introduced. Then, the techniques used to induce multiscale porosity, the nature of the pores created, and the effects of scaffold porosity on mechanical properties and biological activity of the scaffolds are discussed. The review concludes by providing an outlook for this field, including advancements that are made possible by computational modeling and artificial intelligence.

show abstract

Section: Gas Foaming and Sinteringmentioning

confidence: 99%

Glass, Ceramic, Polymeric, and Composite Scaffolds with Multiscale Porosity for Bone Tissue Engineering

Jeyachandran

Cerruti

2023

Adv Eng Mater

View full text Add to dashboard Cite

show abstract

“…Calcium carbonate (CaCO 3, 99.00%) and calcium phosphate (CaHPO 4 , 99.00%) were combined for1/2 h in a 2:1 M ratio. At 1050°C, this combination was calcined with a heating rate of 5°C/min and kept for 6 hours in an electric oven [24].…”

Section: Preparation Of β-Tri-calcium Phosphate (β-Tcp)mentioning

confidence: 99%

Regulation of The antibiotic Elution Profile from Tricalcium Phosphate Bone Cement by Addition of Bioactive Glass

Elwan,

Farag,

Abdelraof

et al. 2023

Preprint

View full text Add to dashboard Cite

Bioactive glass (BG) synthesized by melt-quenching technology, was added in amounts of 5, 10, 15, and 20 weight percent to β-tri-calcium phosphate cement (β-TCP), which was made via a solid state reaction. The cement and its composites' bioactivity behavior was assessed by soaking them in simulated body fluid (SBF) at 37 ± 0.5°C for 28 d. Measurements were made to determine the physico-mechanical characterizes of cement and its composites. After soaking, the pH and concentrations of Ca, and P ion of the SBF solution were estimated. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) combined with energy dispersive spectroscopy (EDS) were used to analyze the structure. Furthermore, by loading gentamicin onto the samples and studying their release profile, the possibility of using them as a drug carrier was explored. A drug release profile that is sustained by all samples was achieved. Addition of bioactive glass to β-TCP decreased drug release rate. Additionally, the antimicrobial property (both bacterial and fungal pathogens) was also assessed. This makes these substances ideal choices for limiting the growth of bacteria once they are implanted in teeth or bone. The results showed that after being submerged in SBF solution, the materials under study develop a layer of hydroxyapatite (HA). It should be highlighted that adding more BG to the current cement composition enhances the material's mechanical and bioactivity characteristics.

show abstract

“…It has recently been demonstrated that the development of nanosized structures and the addition of reinforcement phases can improve the mechanical properties of HAp samples [2][3][4][5][6][7][8][9][10].Several new fabrication techniques such as 3D printing [11], reaction of spherical tricalcium phosphate granules [12], gel casting [7], direct hydrothermal techniques [9] and coating techniques such as MOCVD [13] were proposed in literature for production of porous HAp.…”

Section: Introductionmentioning

confidence: 99%

Production, characterization and properties of open-cell calcium phosphate foams reinforced with alumina

et al. 2019

View full text Add to dashboard Cite

In this study, tailored made open-cell calcium phosphate foams reinforced with alumina were fabricated by employing a dissolution-sintering process, using crystalline raw cane sugar as a water-leachable material. The effect of the alumina addition in the 3D morphology and in the microstructure of the produced calcium phosphate-based foams was examined. Preliminary in vitro bio-dissolution studies were performed to obtain an initial indication for the suitability of these composite bioceramic foams as implant materials. The mechanical properties of the produced composite calcium phosphate foams were also evaluated. It was found that the addition of small amount of alumina (5 wt%) resulted in a microstructural alteration affecting both the 3D geometry of the produced bioceramic foams and the morphology of the precipitated apatite during the biodegradation tests. The addition of alumina resulted in considerable enhancement of the mechanical strength of the bioceramic foam when the porosity was above 70%. The produced calcium phosphatebased composite foams (with alumina reinforcement) are suitable for biomedical applications.

show abstract

Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams

Cited by 10 publications

References 50 publications

Glass, Ceramic, Polymeric, and Composite Scaffolds with Multiscale Porosity for Bone Tissue Engineering

Glass, Ceramic, Polymeric, and Composite Scaffolds with Multiscale Porosity for Bone Tissue Engineering

Regulation of The antibiotic Elution Profile from Tricalcium Phosphate Bone Cement by Addition of Bioactive Glass

Production, characterization and properties of open-cell calcium phosphate foams reinforced with alumina

Contact Info

Product

Resources

About