Preparation and Transdermal Diffusion Evaluation of the Prazosin Hydrochloride-Loaded Electrospun Poly(vinyl alcohol) Fiber Mats

Abstract

This study reports on the use of electrospun polyvinyl alcohol (PVA) nanofiber mats loaded with prazosin hydrochloride (PRH) as a transdermal drug delivery system, investigating the morphology of electrospun PVA nanofibers, the in vitro release characteristics of the drug from the as-spun fibers, and the influence of permeation enhancer (water-resoluble azone, WSA) on transdermal diffusion of PRH through a rat skin. The same was also conducted on the PRH -loaded as-cast PVA films for comparison. Results indicated that the morphology of PRH-loaded PVA fibers observed by scanning electron microscopy (SEM) relied on the electrospinning processing parameters, and the addition of WSA had obvious effects on the diameter and morphology of electrospun PVA fibers. The PRH-loaded electrospun PVA fiber mats exhibited much higher accumulated release dose and release rate of PRH than as-cast PVA films. And WAS can improve the release amount and rate of PRH from drug-loaded samples. The content of PRH in receiver was more than that in the stratum corneum and in the dermis. It was concluded that the PRH-loaded electropun PVA fiber mats as a transdermal patches can be a promising candidate for the conventional preparation.

Electrospun poly(lactic acid) nanofiber mats for controlled transdermal delivery of essential oil from Zingiber cassumunar Roxb

“…This was also demonstrated by Seif et al [28] finding that the release of lysozyme from PVA nanofiber mats was higher than from cast films with the same composition. Furthermore, Shen et al [29] also demonstrated that PVA nanofiber mats showed greater release amount and higher release rate of prazosin hydrochloride than corresponding as-cast films.…”

“…Because of such high surface to volume ratio and excellent controlled release characteristics of electrospun nanofiber mats in comparison to conventional as-cast films [27][28][29], we chose to prepare a tentative controlled transdermal delivery system of Plai oil based on electrospun nanofiber mat. Although electrospun nanofiber mats loaded with Plai oil have been already reported, they were prepared based on the use of water soluble polymer, namely polyvinylpyrrolidone (PVP) [30].…”

Drug loading and delivery using nanofibers scaffolds

“…Fabricated electrospun polymer ultrafine nanofiber scaffolds for the codelivery of green tea polyphenols (GTP) and dexamethasone (DEX) in order to obtain an appropriate balance between effective treatment of keloid and safety to the skin. The histological analysis showed that the GTP/DEX-loaded nanofiber scaffolds meaningfully encourage the degradation of collagen fibers in keloid on the back of nude mice compared with the traditional treatment (Shen et al 2014). Some important applications of nanofibers in transdermal systems and wound dressings are discussed in Table 1.…”

Polyvinyl Alcohol-Nanobioceramic Based Drug Delivery System

“…It has been reported that the ultimate therapeutic and toxic effects produced by a drug, when administered as a solid dosage form and the resultant benefit or risk to a patient, are dependent on the sum of several interacting variables associated with the pharmacological properties of the drug, physiological and pathological factors associated with the patient and the physicochemical properties of the dosage form [1,2]. Several researchers are, therefore, engaged in exploring the physicochemical aspects of dosage forms and their relationship with therapeutic efficacy [3,4]. Different types of drug delivery systems have been developed by manipulating the physicochemical properties such as particle size, compound lipophilicity, surface charge, etc.…”