Preparation and thermal characterization of inclusion complex of Brazilian green propolis and hydroxypropyl-β-cyclodextrin

Rocha, Bruno Alves; Rodrigues, Marina Rezende; Bueno, Paula Carolina Pires; Costa-Machado, Ana Rita de Mello; Vaz, Mirela Mara de Oliveira Lima Leite; Nascimento, Andresa Piacezzi; Barud, Hernane S.; Berretta-Silva, Andresa Aparecida

doi:10.1007/s10973-011-1713-4

Cited by 37 publications

(33 citation statements)

References 38 publications

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“…Dried propolis extract also showed an amorphous structure, and three broad peaks in 15°, 17°, and 23° could be marked, corroborating with previous results for propolis [22]. …”

Section: Resultssupporting

confidence: 90%

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Antimicrobial Brazilian Propolis (EPP-AF) Containing Biocellulose Membranes as Promising Biomaterial for Skin Wound Healing

Barud

Júnior

Saska

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Among remarkable discoveries concerning propolis, such as antifungal, antiviral, and antioxidant activities, its anti-inflammatory, and mainly its antibacterial, properties deserve special attention when skin wound healing is concerned. Based on this and knowing the distinctive performance of bacterial (BC) membranes on wound healing, in this work it is proposed to demonstrate the potent antimicrobial activity and wound healing properties of a novel propolis containing biocellulose membrane. The obtained propolis/BC membrane was able to adsorb propolis not only on the surface, but also in its interstices demonstrated by scanning electron microscopy, X-ray diffraction, Fourier transform infrared (FT-IR) spectroscopy, and thermogravidimetric assays. Additionally, the polyphenolic compounds determination and the prominent antibacterial activity in the membrane are demonstrated to be dose dependent, supporting the possibility of obtaining propolis/BC membranes at the desired concentrations, taking into consideration its application and its skin residence time. Finally, it could be suggested that propolis/BC membrane may favor tissue repair in less time and more effectively in contaminated wounds.

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“…Dried propolis extract also showed an amorphous structure, and three broad peaks in 15°, 17°, and 23° could be marked, corroborating with previous results for propolis [22]. …”

Section: Resultssupporting

confidence: 90%

“…The injection volume was 10 μ L. The column oven was set at 40°C. Detection was set at 275 nm [8, 22]. …”

Section: Methodsmentioning

confidence: 99%

Antimicrobial Brazilian Propolis (EPP-AF) Containing Biocellulose Membranes as Promising Biomaterial for Skin Wound Healing

Barud

Júnior

Saska

et al. 2013

Evidence-Based Complementary and Alternative Medicine

Self Cite

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“…Moreover, EPP-AF has anti-inflammatory [13, 14], antiulcer [15], wound healing, antimicrobial [16, 17], and fungicidal activities [11, 18–21]. Its properties justify the hypothesis to be used as topical treatment of denture stomatitis.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial

Pina

Lia

Berretta

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Our hypothesis tested the efficacy and safety of a mucoadhesive oral gel formulation of Brazilian propolis extract compared to miconazole oral gel for the treatment of denture stomatitis due to Candida spp. infection in older adults. Forty patients were randomly allocated in a noninferiority clinical trial into two groups. The control group (MIC) received 20 mg/g miconazole oral gel and the study group (PROP) received mucoadhesive formulation containing standardized extract of 2% (20 mg/g) propolis (EPP-AF®) during 14 days. Patients were examined on days 1, 7, and 14. The Newton's score was used to classify the severity of denture stomatitis. The colony forming unity count (CFU/mL) was quantified and identified (CHROMagar Candida®) before and after the treatment. Baseline characteristics did not differ between groups. Both treatments reduced Newton's score (P < 0.0001), indicating a clinical improvement of the symptoms of candidiasis with a clinical cure rate of 70%. The microbiological cure with significant reduction in fungal burden on T14 was 70% in the miconazole group and 25% in the EPP-AF group. The EPP-AF appears to be noninferior to miconazole considering the clinical cure rate and could be recommended as an alternative treatment in older patients.

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“…Several studies have reported green propolis to have antiulcerogenic [3], anti-inflammatory [4], antimutagenic [5], antifungal [6–8], immunomodulatory [9], angiogenesis [10], and antioxidant [11] properties. The biological activities of propolis are due to its high levels of phenolic acids [12], while flavonoids are considered responsible for the activities of the European propolis extracts [13].…”

Section: Introductionmentioning

confidence: 99%

Brazilian Green Propolis: Anti-Inflammatory Property by an Immunomodulatory Activity

Machado

Assunção

Silva

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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131

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The immunomodulatory and anti-inflammatory activities of green propolis extracts from Apis mellifera were investigated using acute and chronic inflammation models. Swiss mice were anesthetized and a cotton pellet granuloma was implanted in subcutaneous tissue. Then the mice were divided into six groups and received apyrogenic water or different propolis extracts by oral route (5 mg/kg). According to the treatment the groups were designated as E1A, E1B, E10, E11, and E12. The control group received apyrogenic water. The treatment was performed by six days when the mice were killed. The blood and the bronchoalveolar lavage (BAL) were collected to measure the leukocyte recruitment. In acute pulmonary inflammation, Balb/c mice received lipopolysaccharide (LPS) of Escherichia coli by intranasal route for three days. Concomitantly the mice received by oral route apyrogenic water (control) or E10 and E11 propolis extracts. BAL was performed to assess the inflammatory infiltrate and cytokine quantification. The results showed that the E11 extract has anti-inflammatory property in both models by the inhibition of proinflammatory cytokines and increase of anti-inflammatory cytokines suggesting an immunomodulatory activity.

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Preparation and thermal characterization of inclusion complex of Brazilian green propolis and hydroxypropyl-β-cyclodextrin

Cited by 37 publications

References 38 publications

Antimicrobial Brazilian Propolis (EPP-AF) Containing Biocellulose Membranes as Promising Biomaterial for Skin Wound Healing

Antimicrobial Brazilian Propolis (EPP-AF) Containing Biocellulose Membranes as Promising Biomaterial for Skin Wound Healing

Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial

Brazilian Green Propolis: Anti-Inflammatory Property by an Immunomodulatory Activity

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