Preparation and in Vivo Evaluation of Solid Dispersions Using Repaglinide

Srinivas, I.; Bhikshapathi, D V R N

doi:10.25004/ijpsdr.2018.100502

Cited by 3 publications

(1 citation statement)

References 11 publications

(11 reference statements)

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“…A solubility study [16] was performed to determine the saturation solubility of pure RG as well as for RG-SD. The conical flask containing 25 ml of distilled water and an excess amount of RG-SD was shaken for 24 h at 37±0.5 °C.…”

Section: Solubility Studiesmentioning

confidence: 99%

Optimization, Development and Evaluation of Repaglinide Controlled Release Gastro-Retentive Floating Tablet Using Central Composite Design

PATEL

MASHEER

2023

Int J App Pharm

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Objective: The recent study's objective was to optimize and formulate a controlled-release gastro-retentive floating tablet of RG using a central composite design, which provides continuous release of Repaglinide for up to 24 h. Methods: Repaglinide gastro-retentive floating tablet (RG-GRF Tablet) was prepared by direct compression method. The optimization was carried out using a three-factor and three-level Central Composite design. The amount of Eudragit RSPO (A), HPMC K-100M (B) and Sodium bicarbonate (C) were selected as independent variables and the Cumulative % drug release in 1.5 h (DR1.5), Cumulative % drug release in 8 h (DR8), Cumulative % drug release in 24 h (DR24) and Floating lag time (FLT) were used as dependent variables. Results: CCD analysis results shows that predicted and experimental values for optimized formulation were found to be almost similar. Optimized amounts of Eudragit RSPO, HPMC K-100M, and NaHCO3 were 14.351 mg, 44.438 mg, and 10 mg, respectively, with the highest possible desirability value of 0.898. The experimental values at optimized preparation conditions were found to be DR1.5 is 30.68%, DR8 is 64.90%, DR24 is 96.54%, and FLT is 4.41 min. The release data from the optimized formulation were closely matched with the Korsmeyer-Peppas model and in vitro drug release studies indicated that the RG-GRF Tablet continuously releases the drug for 24 h in a controlled manner. Conclusion: Current research concludes that RG-GRF Tablets provide drug release for up to 24 h, and the derived central composite design can be used for forecasting the DR1.5, DR8 and DR24 as well. RG can also be made more bioavailable by extending the gastric residence time.

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Section: Solubility Studiesmentioning

confidence: 99%

Optimization, Development and Evaluation of Repaglinide Controlled Release Gastro-Retentive Floating Tablet Using Central Composite Design

PATEL

MASHEER

2023

Int J App Pharm

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Pegylated Solid Dispersions for Enhancement of in-vitro Drug Release of Sertraline and Fluoxetine

Divya¹,

Jyothi²

2020

IJPSRR

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The main aim of the study was to enhance dissolution rate of Fluoxetine and Sertraline hydrochloride by formulating as solid dispersions using solvent evaporation method. Fluoxetine and Sertraline solid dispersions were prepared using PEG 4000 as polymer. PEGylated conjugates were prepared in the weight ratios of 1:0.5, 1:1, 1:2, 1:3, and 1:4 using solvent evaporation method. Physicochemical properties were evaluated using solubility studies, FTIR, powder XRD, SEM, dissolution studies. From solubility studies F5, S5 showed highest solubility. From FTIR studies it was proved that there was no interaction between drug and polymer. From SEM and powder XRD studies it was observed that change of polymorphic form of Fluoxetine and Sertraline from crystalline to amorphous form within the solid dispersion. From dissolution studies data it was observed that F5 and S5 showed maximum drug release within 45, 60min respectively, hence they were considered as optimized formulations. Based on the results, it can be concluded that developed solid dispersions was successful to enhance dissolution rate of both the drugs.

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A Comprehensive report on Solid Dispersions by Factorial Design

Ahad¹,

Chinthaginjala²,

Rahamtulla³

et al. 2021

AJRC

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The drugs of present use are lipophilic. Hence there is a need to surge the solubility of these drugs. To encounter this necessity one of the approaches is the formulation of drugs in form of Solid dispersions. Solid dispersions are a type of dispersion having one or extra one API in a torpid carrier at a solid state. We focused on the importance of solid dispersions in pharmaceutical formulation by using factorial design as it was easy to formulate. These solid dispersions are organized by several practises such as solvent technique, supercritical fluid technique and kneading tactic, etc., by referring the several journals, literature and pharmacy magazines we came to know that Solid dispersion are used to improve the solubility of the poor water-soluble drugs and also its bioavailability. At last, we conclude that through these Solid dispersions we can boost the Therapeutic efficiency of hydrophobic drugs by achieving greater solubility.

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Preparation and in Vivo Evaluation of Solid Dispersions Using Repaglinide

Cited by 3 publications

References 11 publications

Optimization, Development and Evaluation of Repaglinide Controlled Release Gastro-Retentive Floating Tablet Using Central Composite Design

Optimization, Development and Evaluation of Repaglinide Controlled Release Gastro-Retentive Floating Tablet Using Central Composite Design

Pegylated Solid Dispersions for Enhancement of in-vitro Drug Release of Sertraline and Fluoxetine

A Comprehensive report on Solid Dispersions by Factorial Design

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