Pegylated Solid Dispersions for Enhancement of in-vitro Drug Release of Sertraline and Fluoxetine

Abstract

The main aim of the study was to enhance dissolution rate of Fluoxetine and Sertraline hydrochloride by formulating as solid dispersions using solvent evaporation method. Fluoxetine and Sertraline solid dispersions were prepared using PEG 4000 as polymer. PEGylated conjugates were prepared in the weight ratios of 1:0.5, 1:1, 1:2, 1:3, and 1:4 using solvent evaporation method. Physicochemical properties were evaluated using solubility studies, FTIR, powder XRD, SEM, dissolution studies. From solubility studies F5, S5 showed highest solubility. From FTIR studies it was proved that there was no interaction between drug and polymer. From SEM and powder XRD studies it was observed that change of polymorphic form of Fluoxetine and Sertraline from crystalline to amorphous form within the solid dispersion. From dissolution studies data it was observed that F5 and S5 showed maximum drug release within 45, 60min respectively, hence they were considered as optimized formulations. Based on the results, it can be concluded that developed solid dispersions was successful to enhance dissolution rate of both the drugs.