A Comprehensive report on Solid Dispersions by Factorial Design

Ahad, Hindustan Abdul; Chinthaginjala, Haranath; Rahamtulla, Syed; Pallavi, Barji Prasanna; Shashanka, Chakali; Prathyusha, Jangam

doi:10.52711/0974-4150.2021.00051

Cited by 12 publications

(2 citation statements)

References 24 publications

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“…In this regard, experimental design may be thought of as a statistical approach that permits the evaluation of several independent factors on a particular response with a restricted number of tests. 7 The effect of each independent variable on a particular response is first explicitly examined. The degree to which one variable affects the others is then calculated using multiple regression.…”

Section: Introductionmentioning

confidence: 99%

Box Behnken’s Design of Fast-Dissolving Ondansetron Buccal Films and Assessing the Impact of Independent Variables on their Swelling and Folding Endurance Constraints

Basha,

Sudha

2024

Ind. J. Pharm. Edu. Res

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Objectives:The project intends to create and evaluate oral fast-dissolving Ondansetron (ODN) films and explore how different plasticizers and polymers affect ondansetron release at varied doses. Materials and Methods: The solvent casting method was used to make the films. Complex formation and compatibility were evaluated using spectral and calorimetric methods to confirm. Utilising the core composite design, which included 13 different Ondansetron Fast-Dissolving Oral Films (OFDOFs) formulas, the produced Ondansetron Fast-Dissolving Oral Films (OFDOFs) were optimised. Using the Design Expert-v.11 software, the impacts of three variables, including HPMC K4M (X 1 ), Carbopol 934 P (X 2 ), and propylene glycol levels (X 3 ), on two responses, Folding Endurance (FE) and Swelling Index (SI), were examined. Numerical optimisation increased the FE (Y 1 ) and maximised the SI (Y 2 ). Results: The statistical analysis findings showed that X 1 greatly enhances Y 1 and Y 2 . While X 2 and X 3 significantly prejudiced the responses optimistically. It was found that the best films were created at the midpoint concentration of both X 1 and X 2 . Moreover, as X 3 levels increased, the elasticity and FE also improved, in addition to the film's quality. Conclusion: The study concludes that the prepared buccal films of ODN exhibited great mechanical and physical qualities in addition to their other physicochemical assets. This dosage form is expected to offer a bioavailability benefit over conventional dosage forms due to its rapid onset of action and anticipated partial avoidance of pre-systemic metabolism.

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Section: Introductionmentioning

confidence: 99%

Box Behnken’s Design of Fast-Dissolving Ondansetron Buccal Films and Assessing the Impact of Independent Variables on their Swelling and Folding Endurance Constraints

Basha,

Sudha

2024

Ind. J. Pharm. Edu. Res

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“…The choice of the appropriate method depends on factors such as the drug's physicochemical properties, desired release characteristics, and the intended dosage form. Solid dispersions are crucial in improving the solubility, dissolution rate, and bioavailability of poorly water-soluble drugs, making them a valuable tool in pharmaceutical development 19 . Carvedilol operates as a dual-action agent, antagonizing α and β adrenoreceptors, and is employed to treat various cardiovascular conditions such as angina, congestive heart failure, cardiac arrhythmias, and hypertension.…”

Section: Introductionmentioning

confidence: 99%

Advancing Carvedilol's Therapeutic Impact: A Study On Solid Dispersion Capsules for Improved Efficacy

Kumar,

PG,

Abdul Ahad

et al. 2024

Int J Life Sci Pharm Res

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This study aimed primarily to improve and evaluate the dissolution rate of Carvedilol by employing a solid dispersiontechnique with β-Cyclodextrin as the carrier. Three distinct methods were utilized to create Carvedilol-containing soliddispersions: The Kneading method, Physical mixture, and Solvent evaporation method. These methods incorporated β-Cyclodextrin at varying drug-carrier ratios (1:1, 1:2, and 1:3). The initial phase encompassed pre-formulation assessments, includingthe establishment of a calibration curve, determination of lambda maximum, melting point determination, investigation of solubilityin different solvents, and evaluation of Carvedilol-polymer compatibility through FTIR analysis. Subsequent post-formulationanalyses included tests for weight variation, Carvedilol content, lock length, moisture permeation, disintegration time, in-vitrodissolution, and stability. The results of the pre-formulation tests were consistent with established references. FTIR analysisrevealed no interactions between the Carvedilol and the carrier. Carvedilol content, weight variation, and disintegration time testsmet the permissible limits outlined in IP standards. Both lock length and moisture permeation tests conformed to the criteria.However, due to Carvedilol's limited solubility, dissolution was inadequate. Among the in-vitro dissolution profiles, the "KN3"formulation, prepared using the Kneading method with a 1:3 ratio of Carvedilol to Carrier, employing β-Cyclodextrin as thecarrier, exhibited superior discharge at 94.671%, outperforming other preparation methods.

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Temperature and Exposure Time Impact on the Extraction of Opuntia ficus-indica and Opuntia dillenii Cladodes on % Yield as a Response: Screening using Design Expert Software

Yadiki

Suggala

Puchalapalli

et al. 2022

GJMPBU

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Objectives: The main aim of the present work is to screen the effect of temperature and exposure time (ET) on the extraction of Opuntia ficus-indica and Opuntia dillenii cladodes. Material and Methods: The literature revealed that few attempts were made on the cladodes and other parts of the plants for extracting constituents from them. However, no attempts were made on screening to find out the impact of dependent variables on the independent response. Design of the experiment using quality by design software, namely, Design Expert was used to reveal the impact of the dependent variable on the response. Results: O. ficus-indica and O. dillenii were poised, authenticated, and were hauled out with water and the effect of dependent variables (temperature and ET) on the response (% yield) was assessed. The equation coded from this study for the % yield was generated as +54.30+0.4061A–0.6432B+0.1500AB+0.8375A2+0.3875B2. Conclusion: The study revealed that 65°C is the optimum temperature and the extraction and ET are directly proportional to extracting the contents from the cladodes.

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A Comprehensive report on Solid Dispersions by Factorial Design

Cited by 12 publications

References 24 publications

Box Behnken’s Design of Fast-Dissolving Ondansetron Buccal Films and Assessing the Impact of Independent Variables on their Swelling and Folding Endurance Constraints

Box Behnken’s Design of Fast-Dissolving Ondansetron Buccal Films and Assessing the Impact of Independent Variables on their Swelling and Folding Endurance Constraints

Advancing Carvedilol's Therapeutic Impact: A Study On Solid Dispersion Capsules for Improved Efficacy

Temperature and Exposure Time Impact on the Extraction of Opuntia ficus-indica and Opuntia dillenii Cladodes on % Yield as a Response: Screening using Design Expert Software

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