Preparation and In-Vitro characterization of Self-Nano emulsifying system of   C- Phenylcalix-[4]-Resorcinaryl Octacinnamate  and C-Methylcalix-[4]-Resorcinaryl Octabenzoate as ultraviolet absorbers

Wiwiek, Indrayani Agung; Martodihardjo, Suwaldi; Soenardi,; Jumina,; Budiana, I Gusti M. N.; Mustofa, .

doi:10.15562/bmj.v6i3.699

Cited by 3 publications

(4 citation statements)

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“…This test aims to measure the clarity of the nanoemulsion. A good nanoemulsion has a transmittance value close to that of water (100%) [24].…”

Section: Transmittant Testmentioning

confidence: 98%

Gingerol and Shogaol Nanoemulsion of Ginger Extract-based Subcritical Water Extraction

Yulianto¹,

Haya²

2023

IJMRA

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The aim of the present study was determine optimum processing conditions and nanoemulsion formulation for the preparation of gingerol and shogaol nanoemulsion from ginger extract-based subcritical water. For this purpose, nanoemulsions were prepared with rotor-stator homogenizer and varied surfactant and cosurfactant concentrations (24%, 26% and 28% v/v), and stirring speed (22,000 rpm, 24,000 rpm). The stirring time is adjusted to 30 minutes. The density, viscosity, pH, % transmittance, nanoemulsion type test, centrifugation test, particle size, zeta potential, and polydispersion index was observed. Nanoemulsion with 28% emulsifier has a % transmittance value closest to 100% indicating that the particle size is estimated at nanometers. The results of test showed that the formed ginger extract nanoemulsion was unstable. Therefore, further studies are needed to find the optimum process conditions and nanoemulsion formulations to form stable

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“…This test aims to measure the clarity of the nanoemulsion. A good nanoemulsion has a transmittance value close to that of water (100%) [24].…”

Section: Transmittant Testmentioning

confidence: 98%

Gingerol and Shogaol Nanoemulsion of Ginger Extract-based Subcritical Water Extraction

Yulianto¹,

Haya²

2023

IJMRA

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“…Tween 80 and Tween 20 are a non-ionic surfactant with low toxicity, better emulsification ability that allowed rapid dispersion when in contact with biological fluids [7], hydrophilelipophile balance value of 15 which can reduce the interface tension between oil and water so that it can help speed up the emulsification time [12]. The value of emulsification time was illustrated by colors that follow the spectrum of light [13]. The high emulsification time value is indicated by increasingly close to blue.…”

Section: Magfirah and Utamimentioning

confidence: 99%

“…High surfactant concentration followed by cosurfactant and olive oil concentration produces a percent transmittance approaching 100% because the surfactant has lipophilic and hydrophilic parts which can reduce the interface stress so that it affects the nanoemulsion formation process, as well as the nanoemulsion droplet size [15]. The value of the transmittance was illustrated by colors that follow the spectrum of light [13]. The higher transmittance value indicated more to red.…”

Section: Magfirah and Utamimentioning

confidence: 99%

“…High surfactant concentration, low concentrations of olive oil produce a large drug loading, this is because surfactants have lipophilic and hydrophilic parts which function to reduce interface stress and have a major effect on the nanoemulsion formation process, as well as the size of the nanoemulsion droplets and cosurfactant amphiphilic compounds, have an affinity to water and oil to reduce interface stress, increase interface fluidity, and increase the mixing of water and oil due to the partition between the two phases to increase the drug loading SNEDDS [15]. The value of the transmittance was illustrated by colors that follow the spectrum of light [13]. The higher transmittance value indicated more to red.…”

Section: Magfirah and Utamimentioning

confidence: 99%

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Optimization and Characterization of Formulation Self-Nanoemulsifying Drug Delivery System Ethanol Extract of Romang Parang Leaves (Boehmeria Virgata)

Magfirah¹,

Utami²

2021

Asian J Pharm Clin Res

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Objective: Parang romang (Boehmeria virgata) is one of the traditional medicines that are used empirically by Makassar tribal healers, South Sulawesi, as an antitumor drug. This traditional medicine contains secondary metabolites such as alkaloids, flavonoids, tannins, and saponins. However, secondary metabolites of those leaves extract have low solubility in water. Hence, to be formula, self-nanoemulsifying drug delivery system (SNEDDS) is one of the solutions to increase the extract solubility. Methods: The optimization of two formula optimum SNEDDS parang romang leaves (T80PGMZ and T20PGMZ) was using the simple lattice design (SLD) method which will give 28 SNEDDS formula parang romang leaves each of which the formula is tested for its characteristics as a critical point include emulsification time, % transmittance, drug loading, particle size, zeta potential, polydispersity index, and morphology particle. Results: The results of SNEDDS characterization obtained the optimum formula T80PGMZ with emulsification time 12.6 s, % transmittance 92.21%, drug loading 68.21 ppm, particle size 370.26 nm, zeta potential −31.4 mV, polydispersity index of 0.615, and regular particle morphology with spherical chunks at a magnification of 10,000 times with a particle size of 10 μm. Conclusion: SNEDDS of parang romang leaves extracts that used olive oil as oil phase, Tween 80 as a surfactant, and propylene glycol as the cosurfactant provided nanoemulsion with good characteristics.

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Development of self nanoemulsifying drug delivery system for black seed oil (Nigella sativa L.)

Priani

Maulidina

Darusman

et al. 2020

J. Phys.: Conf. Ser.

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One strategy to improve oral bioavailability of hydrophobic drugs like black seed oil with formulate them into self nanoemulsifying drug delivery system (SNEDDS). The aim of this study is to develop black seed oil into liquid SNEDDS formulation to enhance oral bioavailability. The optimization of SNEDDS was carried out using various comparison between oil, surfactant and cosurfactant. The formulated SNEDDS were evaluated for transmittance percentage, emulsification time, dispersebility, robustness, thermodynamics stability and globul size determination. The best formulation of SNEDDS obtained from tween 80 as surfactan and PEG 400 as cosurfactant (2:1) with ratio of oil and mix surfactant-cosurfactant 1:8. The formulation of SNEDDS met the requirement of transmittance percentage (97.80%), emulsification time (35.00 second), grade A of dispersibility, stable of robustness and thermodynamic stability tests and the average of globul size was 65.4 nm. The SNEDDS formulation containing black seed oil has good physical characteristic and stability.

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Preparation and In-Vitro characterization of Self-Nano emulsifying system of C- Phenylcalix-[4]-Resorcinaryl Octacinnamate and C-Methylcalix-[4]-Resorcinaryl Octabenzoate as ultraviolet absorbers

Cited by 3 publications

References 0 publications

Gingerol and Shogaol Nanoemulsion of Ginger Extract-based Subcritical Water Extraction

Gingerol and Shogaol Nanoemulsion of Ginger Extract-based Subcritical Water Extraction

Optimization and Characterization of Formulation Self-Nanoemulsifying Drug Delivery System Ethanol Extract of Romang Parang Leaves (Boehmeria Virgata)

Development of self nanoemulsifying drug delivery system for black seed oil (Nigella sativa L.)

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