Preparation and identification of multifunctional mesoporous silica nanoparticles for in vitro and in vivo dual-mode imaging, theranostics, and targeted tracking

Chan, Ming‐Hsien; Lin, Hsiu‐Mei

doi:10.1016/j.biomaterials.2014.12.034

Cited by 123 publications

(62 citation statements)

References 41 publications

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“…It has also been reported that the accumulation of particles in target organs and their clearance rate from the body can be influenced by altering the surface charge and size 7–9 . As a novel drug delivery system, the targeted drug delivery of MSNs has also been studied in detail, and MSNs with surface functionalization of different targeting molecules can exhibit increased aggregation in target organs and cells, or escape uptake by the RES 10–13 . In addition, the in vivo biological behavior and toxicity of nanoparticles have also been investigated 14–20 .…”

Section: Introductionmentioning

confidence: 99%

A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics

Zhao

Wang

et al. 2017

Sci Rep

189

137

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In recent years, spherical nanoparticles has been studied extensively on biomedical applications including bioimaging and biosensing, diagnostics and theranostics, but the effect of the shape of nanoparticles has received little attention. In the present study, we designed three different shaped fluorescent mesoporous silica nanoparticles (MSNs), long rod nanoparticles (NLR), short rod nanoparticles (NSR), and spherical nanoparticles (NS) to systematically examine their behavior in vivo after oral administration. The results of the ex vivo optical imaging study in mice indicated that rod nanoparticles had a longer residence time in the gastrointestinal compared with spherical nanoparticles. The in vivo biodistribution showed that all the orally administered MSNs were mainly taken up by the liver, and kidney. NLR had a great capacity to overcoming rapid clearance by the RES and exhibited a longer circulation in the blood than NSR and NS. During renal excretion, the spherical nanoparticles were cleared faster than rod nanoparticles. In addition, it was also found that MSNs can be degraded in vivo and NSR were degraded faster than NLR and NS probably owing to their higher specific surface area. The pharmacokinetic results demonstrated that nifedipine(NI)-loaded NLR had a higher bioavailability than NI-loaded NSR and NS.

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Section: Introductionmentioning

confidence: 99%

A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics

Zhao

Wang

et al. 2017

Sci Rep

189

137

View full text Add to dashboard Cite

show abstract

“…Furthermore, ferumoxytol has been explored as a companion diagnostic imaging agent in a recent clinical trial, which will be reviewed in more detail in Section 3.1.2. [87][88][89][90][91][92]. Gd may be loaded into or chelated onto the surface of numerous drug-loaded nano and microparticles, such as liposomes, micelles, dendrimers, and silica particles.…”

Section: Dce-mri Dw-mri and Bold-mrimentioning

confidence: 99%

Integration of imaging into clinical practice to assess the delivery and performance of macromolecular and nanotechnology-based oncology therapies

Spence

Souza

Dou

et al. 2015

Journal of Controlled Release

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“…41 In addition, MGC-803 cells have high Glc expression, meaning that the intratumoral distribution of nanoprobes can be further improved. 29 Interestingly, we observed that the nanoprobes internalized by cells were wrapped in a double membrane and were well-dispersed in the cells.…”

Section: Photodynamic Therapy Of Ultra-small Fe 3 O 4 @Polymer-npo/pementioning

confidence: 99%

In vivo high-efficiency targeted photodynamic therapy of ultra-small Fe3O4@polymer-NPO/PEG-Glc@Ce6 nanoprobes based on small size effect

Yin

Zhang

et al. 2017

NPG Asia Mater

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Effectively prolonging the residence time of nanoprobes in the tumor region and reducing the accumulation of nanoprobes in the vital organs (for example, lung, liver and spleen) is crucial for high-efficiency photodynamic therapy (PDT) of cancer. Herein, we systematically report an ultra-small and highly stable nanoplatform with diameters of 4, 8 and 13 nm that exhibited excellent photodynamic therapeutic efficacy using Fe 3 O 4 @polymer-NPO/PEG-Glc@Ce6 nanoprobes. Based on the small size effect, the nanoprobes displayed lower cytotoxicity and excellent biocompatibility. Owing to the synergistic virtues of markedly active targeting and intrinsic small size effect, the Fe 3 O 4 @P-NPO/PEG-Glc@Ce6 nanoprobes can effectively prolong their residence time in the tumor region and reduce accumulation in the normal organs. Benefitting from the small size effect, the synthesized Fe 3 O 4 @P-NPO/PEG-Glc@Ce6 nanoprobes exhibited excellent tumor-targeting capability and photodynamic therapeutic efficacy by inhibiting the growth of tumors in mice under visible red light irradiation with a relatively lower power. The successful application of the small size effect in Fe 3 O 4 @P-NPO/PEG-Glc@Ce6 nanoprobes to significantly improve the PDT efficiency in our strategy suggests new building blocks for PDT of tumors and paves a new way for clinical therapies and translation in the near future.

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Preparation and identification of multifunctional mesoporous silica nanoparticles for in vitro and in vivo dual-mode imaging, theranostics, and targeted tracking

Cited by 123 publications

References 41 publications

A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics

A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics

Integration of imaging into clinical practice to assess the delivery and performance of macromolecular and nanotechnology-based oncology therapies

In vivo high-efficiency targeted photodynamic therapy of ultra-small Fe3O4@polymer-NPO/PEG-Glc@Ce6 nanoprobes based on small size effect

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