Preparation and hemostatic mechanism of bioactive glass-based membrane-like structure camouflage composite particles

Zheng, Caiyun; Liu, Jinxi; Bai, Que; Quan, Yanxiao; Li, Zihao; Chen, Wenting; Gao, Qian; Zhang, Yanni; Lu, Tingli

doi:10.1016/j.matdes.2022.111116

Cited by 13 publications

(5 citation statements)

References 43 publications

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“…It has been demonstrated in many studies that MBG with a highly ordered mesoporous structure showed effective hemostatic activity. It could aggregate blood cells, platelets, and coagulation factors to promote clotting due to its high surface area, water absorption, and hydrophilicity. − In addition to physisorption, the silicon–oxygen groups on the surface endowed the MBG with a negative charge. Notably, the intrinsic pathway of coagulation was activated when blood contacted the negatively charged surface, indicating that MBG could also accelerate the secondary hemostasis.…”

Section: Resultsmentioning

confidence: 99%

Mesoporous Bioactive Glass–Graphene Oxide Composite Aerogel with Effective Hemostatic and Antibacterial Activities

Zheng,

Xue,

et al. 2024

ACS Appl. Bio Mater.

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Hemorrhage and infection after emergency trauma are two main factors that cause deaths. It is of great importance to instantly stop bleeding and proceed with antibacterial treatment for saving lives. However, there is still a huge need and challenge to develop materials with functions of both rapid hemostasis and effective antibacterial therapy. Herein, we propose the fabrication of a composite aerogel mainly consisting of mesoporous bioactive glass (MBG) and graphene oxide (GO) through freeze-drying. This composite aerogel has a three-dimensional porous structure, high absorption, good hydrophilicity, and negative zeta potential. Moreover, it exhibits satisfactory hemostatic activities including low BCI, good hemocompatibility, and activation of intrinsic pathways. When applied to rat liver injury bleeding, it can decrease 60% hemostasis time and 75% blood loss amount compared to medical gauze. On the other hand, the composite aerogel shows excellent photothermal antibacterial capacity against Staphylococcus aureus and Escherichia coli. Animal experiments further verify that this composite aerogel can effectively kill bacteria in wound sites via photothermal treatment and promote wound healing. Hence, this MBG−GO composite aerogel makes a great choice for the therapy of emergency trauma with massive hemorrhage and bacterial infection.

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Section: Resultsmentioning

confidence: 99%

Mesoporous Bioactive Glass–Graphene Oxide Composite Aerogel with Effective Hemostatic and Antibacterial Activities

Zheng,

Xue,

et al. 2024

ACS Appl. Bio Mater.

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“…Zheng et al encapsulated bovine serum albumin (BSA) and chitosan (CS) in a mesoporous bioactive glass (MBG) nanoparticle (MBG@BSA/CS) that activates physiological coagulation pathways. Significant effects were observed on both surface and internal bleeding in SD rats (see Figure 2 below) [ 45 ]. Blood compatibility is one of the main standards for approving all nanomedical devices in contact with blood.…”

Section: Research and Application Of Hemostatic Nanomaterialsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Hemostasis Strategies and Recent Advances in Nanomaterials for Hemostasis

Wang

Yao

et al. 2023

Molecules

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The development of materials that effectively stop bleeding and prevent wound adhesion is essential in both military and medical fields. However, traditional hemostasis methods, such as cautery, tourniquets, and gauze, have limitations. In recent years, new nanomaterials have gained popularity in medical and health fields due to their unique microstructural advantages. Compared to traditional materials, nanomaterials offer better adhesion, versatility, and improved bioavailability of traditional medicines. Nanomaterials also possess advantages such as a high degree and stability, self-degradation, fewer side effects, and improved wound healing, which make them ideal for the development of new hemostatic materials. Our review provides an overview of the currently used hemostatic strategies and materials, followed by a review of the cutting-edge nanomaterials for hemostasis, including nanoparticles and nanocomposite hydrogels. The paper also briefly describes the challenges faced by the application of nanomaterials for hemostasis and the prospects for their future development.

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“…Rat without treatment was treated as blank. 30 2.2.12. Histopathological examination of rabbit's colon.…”

Section: Magnetic Microspheres (Mm) With and Withoutmentioning

confidence: 99%

Chitosan-coated halloysite nanotube magnetic microspheres for carcinogenic colorectal hemorrhage and liver laceration in albino rats

et al. 2023

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Preparation and hemostatic mechanism of bioactive glass-based membrane-like structure camouflage composite particles

Cited by 13 publications

References 43 publications

Mesoporous Bioactive Glass–Graphene Oxide Composite Aerogel with Effective Hemostatic and Antibacterial Activities

Mesoporous Bioactive Glass–Graphene Oxide Composite Aerogel with Effective Hemostatic and Antibacterial Activities

Hemostasis Strategies and Recent Advances in Nanomaterials for Hemostasis

Chitosan-coated halloysite nanotube magnetic microspheres for carcinogenic colorectal hemorrhage and liver laceration in albino rats

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