Chitosan-coated halloysite nanotube magnetic microspheres for carcinogenic colorectal hemorrhage and liver laceration in albino rats

Majeed, Sajid; Qaiser, M.; Shahwar, Dure; Ahmed, Nadeem; Hanif, Muhammad; Abbas, Ghulam; Shoaib, Mohammad; Ameer, Nabeela; Khalid, Muhammad

doi:10.1039/d3ra01581e

Cited by 3 publications

(2 citation statements)

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“…Likewise, the addition of HNTs enhanced the anti-inflammatory and analgesic effects of ketorolac and reduced gastric hemorrhagic ulcers and mucosal lesions in rats (Figure e) . Chitosan-coated HNT microspheres were found to alleviate carcinogenic colorectal hemorrhage in rats …”

Section: Biomedical Applicationsmentioning

confidence: 84%

“…115 Chitosan-coated HNT microspheres were found to alleviate carcinogenic colorectal hemorrhage in rats. 116 A clinical study demonstrated that a traditional Chinese medicine called "Taohua Tang" prepared from halloysite, dried ginger, and rice, could alleviate diarrhea and promote mucosal recovery. This formulation is especially useful for improving clinical outcomes in patients with antibiotic-associated diarrhea.…”

Section: Gastrointestinal Disease Treatmentmentioning

confidence: 99%

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The Horizons of Medical Mineralogy: Structure-Bioactivity Relationship and Biomedical Applications of Halloysite Nanoclay

Feng,

Chen,

et al. 2024

ACS Nano

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Medical mineralogy explores the interactions between natural minerals and living organisms such as cells, tissues, and organs and develops therapeutic and diagnostic applications in drug delivery, medical devices, and healthcare materials. Many minerals (especially clays) have been recognized for pharmacological activities and therapeutic potential. Halloysite clay (Chinese medicine name: Chishizhi), manifested as onedimensional aluminum silicate nanotubes (halloysite nanotubes, HNTs), has gained applications in hemostasis, wound repair, gastrointestinal diseases, tissue engineering, detection and sensing, cosmetics, and daily chemicals formulations. Various biomedical applications of HNTs are derived from hollow tubular structures, high mechanical strength, good biocompatibility, bioactivity, and unique surface characteristics. This natural nanomaterial is safe, abundantly available, and may be processed with environmentally safe green chemistry methods. This review describes the structure and physicochemical properties of HNTs relative to bioactivity. We discuss surface area, porosity and surface defects, hydrophilicity, heterogeneity and charge of external and internal surfaces, as well as biosafety. The paper provides comprehensive guidance for the development of this tubule nanoclay and its advanced biomedical applications for clinical diagnosis and therapy.

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Section: Biomedical Applicationsmentioning

confidence: 84%

Section: Gastrointestinal Disease Treatmentmentioning

confidence: 99%