Preparation and heat-insulating properties of Al₂O₃–ZrO₂(Y₂O₃) hollow fibers derived from cogon using an orthogonal experimental design

Abstract

Lightweight Al2O3–ZrO2(Y2O3) hollow fibers with low thermal conductivity were prepared by a natural template—cogon grass.

Optimization of Tilmicosin-Loaded Nanostructured Lipid Carriers Using Orthogonal Design for Overcoming Oral Administration Obstacle

“…The range of HD values was from 292.50 ± 1.65 nm to 595.30 ± 33.99 nm in the orthogonal design experiment. According to the R values, in which a higher R value represents more significant effect [20], the effect of four factors decreased in the following order: C > B > A > D (Table 2), indicating C, i.e., the ratio of drug to mixed lipids, was the most important effect among these four factors set in this study. In addition, K1, K2, and K3 in Table 2 represented the mean values of evaluation index for the three levels corresponding to one factor.…”

“…Furthermore, it was proved that TMS-NLCs were an effective formulation with excellent drug loading, encapsulation efficiency, and stability, which enhanced the transcellular transport across Caco-2 cells and escaped the lysosome degradation [19]. An orthogonal experimental design is broadly applied in many fields to investigate the relative importance of each factor and identify the ideal values for various factors [20]. In this study, an orthogonal experimental design was utilized to evaluate the effect of different factors on TMS-NLCs with smaller hydrodynamic diameter (HD), high drug loading (DL), and uniform dispersion.…”