Optimization of Tilmicosin-Loaded Nanostructured Lipid Carriers Using Orthogonal Design for Overcoming Oral Administration Obstacle

Wen, Jia; Gao, Xiaona; Zhang, Qian; Sahito, Benazir; Si, Hongbin; Li, Gonghe; Ding, Qi; Wu, Weijie; Nepovimová, Eugenie; Jiang, Shanxiang; Wang, Liping; Kuča, Kamil; Guo, Dawei

doi:10.3390/pharmaceutics13030303

Cited by 4 publications

(5 citation statements)

References 44 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the effect of four factors decreased in the following order: A > D > B > C, indicating A, i.e., the concentration of iodine in potassium iodide solution, was the most important one among the factors. In Table 2, K1, K2, and K3 represented the mean values of the evaluation index for the three levels corresponding to one factor [23]. The higher concentration of iodine would contribute to the iodine loading.…”

Section: Uio-66-nh 2 Loading Iodinementioning

confidence: 99%

Iodine Immobilized UiO-66-NH2 Metal-Organic Framework as an Effective Antibacterial Additive for Poly(ε-caprolactone)

et al. 2022

View full text Add to dashboard Cite

Iodine has been widely used as an effective disinfectant with broad-spectrum antimicrobial potency. However, the application of iodine in an antibacterial polymer remains challenging due to its volatile nature and poor solubility. Herein, iodine immobilized UiO-66-NH2 metal-organic framework (MOF) (UiO66@I2) with a high loading capacity was synthesized and used as an effective antibacterial additive for poly(ε-caprolactone) (PCL). An orthogonal design approach was used to achieve the optimal experiments’ conditions in iodine adsorption. UiO66@I2 nanoparticles were added to the PCL matrix under ultrasonic vibration and evaporated the solvent to get a polymer membrane. The composites were characterized by SEM, XRD, FTIR, and static contact angle analysis. UiO-66-NH2 nanoparticles have a high iodine loading capacity, up to 18 wt.%. The concentration of iodine is the most important factor in iodine adsorption. Adding 0.5 wt.% or 1.0 wt.% (equivalent iodine content) of UiO66@I2 to the PCL matrix had no influence on the structure of PCL but reduces the static water angle. The PCL composites showed strong antibacterial activities against Staphylococcus aureus and Escherichia coli. In contrast, the same content of free iodine/PCL composites had no antibacterial activity. The difference in the antibacterial performance was due to the different iodine contents in the polymer composites. It was found that MOF nanoparticles could retain most of the iodine during the sample preparation and storage, while there was few iodine left in the free iodine/PCL composites. This study offers a common and simple way to immobilize iodine and prepare antibacterial polymers with low antiseptic content that would reduce the influence of an additive on polymers’ physical properties.

show abstract

Section: Uio-66-nh 2 Loading Iodinementioning

confidence: 99%

Iodine Immobilized UiO-66-NH2 Metal-Organic Framework as an Effective Antibacterial Additive for Poly(ε-caprolactone)

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Based on the literature [ 19 , 20 , 21 ] and previously conducted experiments, the following four key factors that affect the encapsulation efficiency of RTPUU microcapsules were selected: (1) the N3300-to-L75 shell material mass ratio, (2) core-to-shell material mass ratio, (3) emulsifier concentration, and (4) shear rate during emulsification. Subsequently, a four-factor and three-level orthogonal experiment ( Table 1 and Table 2 ) was designed using the Orthogonality Experiment Assistant II software (Sharetop Software Studio, V 3.1, Beijing Qingsi Technology Co., Ltd. (Beijing, China)).…”

Section: Methodsmentioning

confidence: 99%

Reversible Thermochromic Microcapsules and Their Applications in Anticounterfeiting

et al. 2023

View full text Add to dashboard Cite

The common, commercial reversible thermochromic (RT) melamine–formaldehyde resin microcapsules containing formaldehyde are very harmful to human health. To address this issue, we successfully prepared a novel formaldehyde-free microcapsule via interfacial polymerization using RT compositions as the core and poly(urethane-urea) (PUU) as the shell. The core material consisted of a color former (crystal violet lactone), a developer (bisphenol AF), and a solvent (methyl stearate). To optimize the synthesis of the microcapsules, an L9 (34) orthogonal design and single-factor experiments were employed to analyze the effects of four factors (N3300-to-L75 shell material mass ratio, core-to-shell material mass ratio, emulsifier concentration, and shear rate during emulsification) on the encapsulation efficiency. The results showed that the optimal parameter values were as follows: a shear rate of 2500 rpm, N3300-to-L75 shell material mass ratio of 1:4, core-to-shell material mass ratio of 11:5, and emulsifier concentration of 3.5%. The influence of the shear rate on the particle size and distribution, surface morphology, dispersibility, and reversible thermochromic properties of the microcapsules was investigated. Furthermore, analyses on the phase-change characteristics, thermal stability, ultraviolet aging, and solvent and acid–base resistances of the microcapsules were conducted systematically. Finally, a reversible thermochromic mark containing the RTPUU microcapsules was designed and fabricated, which could be used against falsification. Moreover, these RTPUU microcapsules can be potentially used for anticounterfeiting applications.

show abstract

“…Poor stability, low intestinal absorption rates, and bioavailability hinder the development of plant products (Basu et al, 2023; McClements, 2020; Rahman et al, 2020; Z. Zhang, He, et al, 2021). For example, certain orally administered plant compounds undergo degradation by the reticuloendothelial system and proteolytic enzymes after entering the bloodstream, decreasing the plasma drug concentration and bioavailability (Jana et al, 2021; Z. Li, Zhu, et al, 2023; J. Wen, Gao, et al, 2021; Xiao et al, 2021). Additionally, due to the first‐pass effect in the liver (Basto et al, 2021; Varma et al, 2010; Q. Yan et al, 2021), active compounds might be metabolized into highly polar excretable forms (X. Feng et al, 2021; Sharifi et al, 2012; Viera et al, 2018), altering their molecular structure and pharmacological activity (Alferiev et al, 2015; X. Wang, Hui, et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…For example, certain orally administered plant compounds undergo degradation by the reticuloendothelial system and proteolytic enzymes after entering the bloodstream, decreasing the plasma drug concentration and bioavailability (Jana et al, 2021;Z. Li, Zhu, et al, 2023;J. Wen, Gao, et al, 2021;Xiao et al, 2021).…”

mentioning

confidence: 99%

The development of nanocarriers for natural products

Huang,

Luo,

Tong

et al. 2024

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Natural bioactive compounds from plants exhibit substantial pharmacological potency and therapeutic value. However, the development of most plant bioactive compounds is hindered by low solubility and instability. Conventional pharmaceutical forms, such as tablets and capsules, only partially overcome these limitations, restricting their efficacy. With the recent development of nanotechnology, nanocarriers can enhance the bioavailability, stability, and precise intracellular transport of plant bioactive compounds. Researchers are increasingly integrating nanocarrier‐based drug delivery systems (NDDS) into the development of natural plant compounds with significant success. Moreover, natural products benefit from nanotechnological enhancement and contribute to the innovation and optimization of nanocarriers via self‐assembly, grafting modifications, and biomimetic designs. This review aims to elucidate the collaborative and reciprocal advancement achieved by integrating nanocarriers with botanical products, such as bioactive compounds, polysaccharides, proteins, and extracellular vesicles. This review underscores the salient challenges in nanomedicine, encompassing long‐term safety evaluations of nanomedicine formulations, precise targeting mechanisms, biodistribution complexities, and hurdles in clinical translation. Further, this study provides new perspectives to leverage nanotechnology in promoting the development and optimization of natural plant products for nanomedical applications and guiding the progression of NDDS toward enhanced efficiency, precision, and safety.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

show abstract

Optimization of Tilmicosin-Loaded Nanostructured Lipid Carriers Using Orthogonal Design for Overcoming Oral Administration Obstacle

Cited by 4 publications

References 44 publications

Iodine Immobilized UiO-66-NH2 Metal-Organic Framework as an Effective Antibacterial Additive for Poly(ε-caprolactone)

Iodine Immobilized UiO-66-NH2 Metal-Organic Framework as an Effective Antibacterial Additive for Poly(ε-caprolactone)

Reversible Thermochromic Microcapsules and Their Applications in Anticounterfeiting

The development of nanocarriers for natural products

Contact Info

Product

Resources

About