Preparation and evaluation of wound healing activity of phytosomes of crocetin from Nyctanthes arbor-tristis in rats

Varadkar, Manasi; Gadgoli, Chhaya

doi:10.1016/j.jtcme.2021.10.002

Cited by 11 publications

(4 citation statements)

References 24 publications

(16 reference statements)

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“…Sinigrin phytosomes demonstrated enhanced wound healing properties on the HaCaT cell line compared to free sinigrin [39]. Varadkar and Gadgoli [56] investigated the wound healing properties of corcetin phytosomes (F2) gel preparation. F2 showed improved wound healing in rats demonstrated by an increase of the level of hydroxyproline.…”

Section: Wound Healing Propertiesmentioning

confidence: 99%

Emerging Techniques for Herbosomes

M. Dogheim,

A. Abd El-Maksod,

A. El-Maradny

et al. 2024

Dosage Forms - Emerging Trends and Prospective Drug-Delivery Systems [Working Title]

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Herbosomes are a relatively new technology that involves encapsulating herbal extracts in liposomes, which are tiny spheres made of phospholipids. This allows for better absorption of the herbal compounds into the body. Herbosomes have a higher bioavailability compared to traditional herbal extracts, improved stability and can be designed to target specific areas of the body, as well as reduced side effects as they can be delivered in smaller doses. The production of herbosomes involves the use of various techniques including solvent injection, thin-film hydration, and sonication. The production of herbosomes involves the use of various techniques that aim to create stable and effective nanocarriers for herbal extracts. There is limited research available on the safety and toxicity of herbosomes specifically, but studies have been conducted on the safety of lipid-based nanoparticles in general. It is important to note that the safety and toxicity of herbosomes may vary depending on the specific herbal extract and lipid used in their formulation. Further research is needed to fully understand the potential risks and benefits of using herbosomes as a drug delivery system. In conclusion, herbosomes offer several advantages over traditional herbal extracts, making them a promising technology for the development of new herbal products.

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Section: Wound Healing Propertiesmentioning

confidence: 99%

Emerging Techniques for Herbosomes

M. Dogheim,

A. Abd El-Maksod,

A. El-Maradny

et al. 2024

Dosage Forms - Emerging Trends and Prospective Drug-Delivery Systems [Working Title]

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show abstract

“…[36] Chhaya Gadgoli has developed crocetin-based hydrogel for enhancing the wound healing activity and showed good wound healing potential. [37] However, the limit of traditional Chinese medicine on solubility hinders the dosage of drugs and the application on biomedicine.…”

Section: Introductionmentioning

confidence: 99%

“…Majid Rahmati has reported an alginate and chitosan hydrogel with loading crocetin, and this hydrogel can improve wound healing process and enhance the expression of Collagen type I, III, VEGF, and TGF‐β [36] . Chhaya Gadgoli has developed crocetin‐based hydrogel for enhancing the wound healing activity and showed good wound healing potential [37] . However, the limit of traditional Chinese medicine on solubility hinders the dosage of drugs and the application on biomedicine.…”

Section: Introductionmentioning

confidence: 99%

pH‐Responsive Calcium Ions and Crocetin Releasing Hydrogel for Accelerating Skin Wound Healing

Wang,

Ma,

Pan

et al. 2024

Chemistry An Asian Journal

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The ideal and highly anticipated dressing for skin wounds should provide a moist environment, possess antibacterial properties, and ensure sustained drug release. In the present work, a pH‐responsive hyaluronic acid‐based hydrogel (CPC@HA hydrogel) was formed by hydrogen bond and amido bond cross‐linking after introducing crocetin (Cro) and CaCO3@polyelectrolyte microspheres (CaCO3@PEM) to HA hydrogel to sustained, controlled release of the calcium ions and crocetin under slightly acid to accelerating skin wounds healing. The experiment results showed that the CPC@HA hydrogel exhibited porous network structures, stable physical properties, and had antibacterial properties and biocompatibility in vitro. In addition, the CPC@HA hydrogel covering on the skin wound could reduce inflammation and promote wound healing. The high expression of angiogenic cytokines (CD31) and epidermal terminal differentiation markers (Loricrin) of wound healing tissue suggested the CPC@HA hydrogel also had the function of promoting the remodeling of regenerated skin. Overall, CPC@HA hydrogel has promising potential for clinical applications in accelerated skin wound repair.

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“…Compounds of the crocin family are the monoglycosyl, diglycosyl, or triglycosyl products of 8,8′-diapocarotene-8,8′-dioic acid (crocetin, 1 ) or derivatives thereof. In addition to C. sativus and G. jasminoides , Buddleja officinalis and Buddleja davidii from the Loganiaceae family [ 1 – 2 ], Nyctanthes arbor-tristis from the Oleaceae family [ 3 ], and Arctium lappa from the Compositae family also contain crocins [ 4 ]. The content of crocins varies significantly among different plant species and different organs of the same plant.…”

Section: Introductionmentioning

confidence: 99%

Research progress on the pharmacological activity, biosynthetic pathways, and biosynthesis of crocins

Hua,

Liu,

Yan

2024

Beilstein J. Org. Chem.

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Crocins are water-soluble apocarotenoids isolated from the flowers of crocus and gardenia. They exhibit various pharmacological effects, including neuroprotection, anti-inflammatory properties, hepatorenal protection, and anticancer activity. They are often used as coloring and seasoning agents. Due to the limited content of crocins in plants and the high cost of chemical synthesis, the supply of crocins is insufficient to meet current demand. The biosynthetic pathways for crocins have been elucidated to date, which allows the heterologous production of these valuable compounds in microorganisms by fermentation. This review article provides a comprehensive overview of the chemistry, pharmacological activity, biosynthetic pathways, and heterologous production of crocins, aiming to lay the foundation for the large-scale production of these valuable natural products by using engineered microbial cell factories.

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Preparation and evaluation of wound healing activity of phytosomes of crocetin from Nyctanthes arbor-tristis in rats

Cited by 11 publications

References 24 publications

Emerging Techniques for Herbosomes

Emerging Techniques for Herbosomes

pH‐Responsive Calcium Ions and Crocetin Releasing Hydrogel for Accelerating Skin Wound Healing

Research progress on the pharmacological activity, biosynthetic pathways, and biosynthesis of crocins

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