Preparation and evaluation of a reversed-phase/hydrophilic interaction/ion-exchange mixed-mode chromatographic stationary phase functionalized with dopamine-based dendrimers

Zhou, Di; Zeng, Jing; Fu, Qifeng; Gao, Die; Zhang, Kailian; Ren, Xiujun; Xia, Zhining; Wang, Lujun

doi:10.1016/j.chroma.2018.08.018

Cited by 36 publications

(7 citation statements)

References 46 publications

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“…Simultaneously, many functional foods have been obtained from the roots, stems, and leaves of A. manihot because of their abundant nucleotides, nucleosides, and nucleobases ( Du L. Y. et al., 2015 ). Furthermore, nucleotides, nucleosides, and nucleobases have been regarded as quality control markers for many traditional Chinese medicines, such as royal jelly, Mactra veneriformis , and Cordyceps sinensis ( Liu R. et al., 2012 ; Wu et al., 2015 ; Lin et al., 2018 ; Zhou et al., 2018 ).…”

Section: Traditional Usesmentioning

confidence: 99%

Traditional Uses, Chemical Constituents, Biological Properties, Clinical Settings, and Toxicities of Abelmoschus manihot L.: A Comprehensive Review

Luan

Wu²,

Yang

et al. 2020

Front. Pharmacol.

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Abelmoschus manihot , an annual herbal flowering plant, is widely distributed throughout eastern Europe and in temperate and subtropical regions of Asia. Its flowers have been traditionally used for the treatment of chronic kidney disease in China. Currently, more than 128 phytochemical ingredients have been obtained and identified from the flowers, seeds, stems, and leaves of A. manihot . The primary components are flavonoids, amino acids, nucleosides, polysaccharides, organic acids, steroids, and volatile oils. A. manihot and its bioactive constituents possess a plethora of biological properties, including antidiabetic nephropathy, antioxidant, antiadipogenic, anti-inflammatory, analgesic, anticonvulsant, antidepressant, antiviral, antitumor, cardioprotective, antiplatelet, neuroprotective, immunomodulatory, and hepatoprotective activities, and have effects on cerebral infarction, bone loss, etc. However, insufficient utilization and excessive waste have already led to a rapid reduction of resources, meaning that a study on the sustainable use of A. manihot is urgent and necessary. Moreover, the major biologically active constituents and the mechanisms of action of the flowers have yet to be elucidated. The present paper provides an early and comprehensive review of the traditional uses, chemical constituents, pharmacological activities, and pharmaceutical, quality control, toxicological, and clinical settings to emphasize the benefits of this plant and lays a solid foundation for further development of A. manihot .

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Section: Traditional Usesmentioning

confidence: 99%

Traditional Uses, Chemical Constituents, Biological Properties, Clinical Settings, and Toxicities of Abelmoschus manihot L.: A Comprehensive Review

Luan

Wu²,

Yang

et al. 2020

Front. Pharmacol.

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“…As the heart of high-performance liquid chromatography (HPLC) systems, stationary phases have drawn extensive attention. To meet the growing demand in different fields, various stationary phases used for HPLC have been developed. − Recently, stationary phases with mixed-mode mechanisms have emerged as the hot research topic, owing to the advantages of much higher sample loading capability, high selectivity, and good separation efficiency over the classical single-mode stationary phases. − Up to now, many kinds of mixed-mode stationary phases, including ion exchange chromatography (IEC)/reversed-phase liquid chromatography (RPLC), − hydrophilic interaction liquid chromatography (HILIC)/RPLC, ,, HILIC/IEC − and RPLC/HILIC/IEC, , were reported and applied in a number of separation fields. However, the search for multifarious stationary phases is still a growing demand in order to resolve the tasks of ever-evolving actual applications.…”

Section: Introductionmentioning

confidence: 99%

Core–Shell Metal–Organic Frameworks as the Mixed-Mode Stationary Phase for Hydrophilic Interaction/Reversed-Phase Chromatography

Liu

et al. 2019

ACS Appl. Mater. Interfaces

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Stationary phases with mixed-mode mechanisms have emerged as a hot research topic. In the present research, monodisperse core−shell UiO-67@SiO 2 materials were prepared and further served as the packed column for mixed-mode hydrophilic interaction liquid chromatography/reversed-phase liquid chromatography. The developed UiO-67@SiO 2 materials were characterized via thermogravimetric analysis, scanning electron microscopy, X-ray Powder diffraction, and Fourier transform infrared techniques. The developed UiO-67@SiO 2 column shows flexible selectivity for separation of both hydrophobic (anilines, alkylbenzenes, and polycyclic aromatic hydrocarbons) and hydrophilic (thioureas) compounds. Furthermore, the UiO-67@SiO 2 column was also utilized to characterize potential pollutants in lake water samples. In summary, the UiO-67@SiO 2 column provided flexible selectivity and wide-range retention behaviors for both hydrophilic and hydrophobic analytes.

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“…3−6 For example, Zhou et al prepared a dopamine-based dendrimer stationary phase, which provided good performance separation of hydrophobic and polar analytes using RPLC or HILIC. 3 Over the past decades, the development of HPLC column packing material has been ever-accelerating owing to interdisciplinary expansion of separation science and new porous materials, such as metal−organic frameworks (MOFs) 7−14 and covalent organic frameworks (COFs). 15−20 Hybrid particles with a silica core and porous shell combine the advantages of the shell material and the easy packing/ mechanical stability of the silica core, which enhance the separation efficiency.…”

Section: Introductionmentioning

confidence: 99%

“…In the case of such complex separation systems, a single-mode stationary phase often fails to provide proper retention and separation selectivity. Mixed-mode chromatography (MMC) possesses multiple chromatographic ligands that provide multimodal interactions, enhancing the separation selectivity of complex mixtures of solutes that vastly differ in physicochemical characteristics. , Among the different types of mixed-mode stationary phases, RP/HILIC mixed-mode stationary phases are embedded with both hydrophobic and hydrophilic moieties in order to separate both polar and nonpolar analytes. − For example, Zhou et al prepared a dopamine-based dendrimer stationary phase, which provided good performance separation of hydrophobic and polar analytes using RPLC or HILIC . Guo et al immobilized β-cyclodextrin on a silica surface for mixed-mode separation of flavone glycosides by HILIC/RPLC …”

Section: Introductionmentioning

confidence: 99%

Controlled Fabrication of Silica@Covalent Triazine Polymer Core–Shell Spheres as a Reversed-Phase/Hydrophilic Interaction Mixed-Mode Chromatographic Stationary Phase

Zuo

Guo

Zhao

et al. 2019

ACS Appl. Mater. Interfaces

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The unique properties of covalent triazine-based organic framework/polymers, including large surface area, hydrophilic–lipophilic-balanced adsorption, and economical preparation, make it a promising candidate as a stationary phase for high-performance liquid chromatography. However, irregular shapes and wide size distributions of such particles hinder column packing, resulting in a low column efficiency or a high back pressure. Herein, we describe the fabrication of SiO2@ covalent triazine-based organic polymer (CTP) core–shell microspheres with a distinct sphere-coating-sphere appearance using aminosilica as the supporting substrate to grow the CTP shell. By adjusting the amount of reactants, the thickness of the CTP shell, which consists of triazine and 1,3,5-triphenylbenzene monomers, was easily controlled. The developed core–shell microspheres were characterized via scanning electron microscopy, energy dispersive X-ray spectroscopy, transmission electron microscopy, solid-state 13C nuclear magnetic resonance analysis, and N2 adsorption experiments. The synergism of the triazine and aromatic moieties on CTP provides the new stationary phase with multiple retention mechanisms, including hydrophobic, π–π, electron donor–acceptor, hydrogen-bonding interactions, and so forth. On the basis of these interactions, successful separation and higher shape selectivity were achieved among several analytes that vary in polarity under both reversed-phase and hydrophilic interaction liquid chromatography conditions. Therefore, SiO2@CTP microspheres combine the advantages of good column packing properties of the uniform monodisperse silica microspheres and the recognition performance of CTP, generating flexible selectivity and application prospect for both hydrophilic and hydrophobic analytes.

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Preparation and evaluation of a reversed-phase/hydrophilic interaction/ion-exchange mixed-mode chromatographic stationary phase functionalized with dopamine-based dendrimers

Cited by 36 publications

References 46 publications

Traditional Uses, Chemical Constituents, Biological Properties, Clinical Settings, and Toxicities of Abelmoschus manihot L.: A Comprehensive Review

Traditional Uses, Chemical Constituents, Biological Properties, Clinical Settings, and Toxicities of Abelmoschus manihot L.: A Comprehensive Review

Core–Shell Metal–Organic Frameworks as the Mixed-Mode Stationary Phase for Hydrophilic Interaction/Reversed-Phase Chromatography

Controlled Fabrication of Silica@Covalent Triazine Polymer Core–Shell Spheres as a Reversed-Phase/Hydrophilic Interaction Mixed-Mode Chromatographic Stationary Phase

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