Core–Shell Metal–Organic Frameworks as the Mixed-Mode Stationary Phase for Hydrophilic Interaction/Reversed-Phase Chromatography

Abstract

Stationary phases with mixed-mode mechanisms have emerged as a hot research topic. In the present research, monodisperse core−shell UiO-67@SiO 2 materials were prepared and further served as the packed column for mixed-mode hydrophilic interaction liquid chromatography/reversed-phase liquid chromatography. The developed UiO-67@SiO 2 materials were characterized via thermogravimetric analysis, scanning electron microscopy, X-ray Powder diffraction, and Fourier transform infrared techniques. The developed UiO-67@SiO 2 column shows flexible selectivity for separation of both hydrophobic (anilines, alkylbenzenes, and polycyclic aromatic hydrocarbons) and hydrophilic (thioureas) compounds. Furthermore, the UiO-67@SiO 2 column was also utilized to characterize potential pollutants in lake water samples. In summary, the UiO-67@SiO 2 column provided flexible selectivity and wide-range retention behaviors for both hydrophilic and hydrophobic analytes.

Hydrogel Coating with Temperature Response Retention Behavior and Its Application in Selective Separation of Liquid Chromatography

“…As a newly developed liquid chromatography packing, it is also very important to compare it with the commercial chromatographic column and other excellent stationary phases (Table S10). − It shows that the DL-hydrogel@SiO 2 stationary phase has good chromatographic performance over the commercial mixed mode column and newly reported good performance liquid chromatography stationary phases in some cases. The DL-hydrogel@SiO 2 column also has certain advantages in terms of column efficiency and selectivity.…”

Recent trends on the implementation of reticular materials in column‐centered separations

“…The resulting packing showed to be highly robust with a very low RSD of 0.89% for the retention times of trans-stilbene oxides over at least 250 injections (Figure 1E). Silica particles have been used as a substrate to prepare core-shell HPLC stationary phases based on the MOF UiO-67 (Universitetet i Oslo-67, Zr(IV)-4,4′biphenyldicarboxylic acid) [31]. Here, commercial silica particles (5 μm diameter) with amino functional groups were selected as starting material.…”

Recent progress in the development of chiral stationary phases for high‐performance liquid chromatography

“…One possible approach to overcome these issues is to prepare uniform spherical MOF composites since they combine the perfect column packing and chromatographic separation properties of a spherical substrate with the merits of MOFs. Therefore, MOF@SiO 2 sphere core-shell composite-based stationary phases have been developed in recent years [197][198][199].…”