Preparation and evaluation of a novel glass-ionomer cement with antibacterial functions

Xie, Dong; Weng, Yiming; Guo, Xia; Zhao, Jun; Gregory, Richard L.; Zheng, Cunge

doi:10.1016/j.dental.2011.02.006

Cited by 172 publications

(175 citation statements)

References 27 publications

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“…While in the case of polycations with chloride and bromide as the counter anions, both the anions are halides and can dissociate freely in water. Chen et al [32] and Xie et al [33] found the same potency difference of biocides as comparing the influence of different haloid anions on their antibacterial performance. Nevertheless, so far no interpretation has been put forward.…”

Section: Evaluation Of Antimicrobial Activitymentioning

confidence: 92%

Antibacterial/Antiviral Property and Mechanism of Dual-Functional Quaternized Pyridinium-type Copolymer

Xue

Xiao

2015

Polymers

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Due to the massive outbreaks of pathogen-caused diseases and the increase of drug-resistant pathogens, there is a particular interest in the development of novel disinfection agents with broad-spectrum antipathogenic activity.In the present study, water-soluble pyridinium-type polyvinylpyrrolidones with different counter anions were prepared. Structural characterization was conducted via 13 C-1 H heteronuclear single quantum coherence spectroscopy, static light scattering, UV spectrometry and apparent charge density. The influence of counter anion and polymer compositions on the antibacterial activity was studied against Staphylococcus aureus and Escherichia coli. Atomic force microscopy (AFM) was applied for tracking the morphological alterations in bacterial cells induced by prepared polycations. It was found that the exposure of bacteria to the polycations resulted in the destruction of cell membranes and the leakage of cytoplasm. The antiviral activity of pyridinium-type polycations against enveloped influenza virus was evaluated via a plaque assay. The action mode against enveloped virus was depicted to rationalize the antiviral mechanism.

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Section: Evaluation Of Antimicrobial Activitymentioning

confidence: 92%

Antibacterial/Antiviral Property and Mechanism of Dual-Functional Quaternized Pyridinium-type Copolymer

Xue

Xiao

2015

Polymers

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“…The absorbance was measured at 595 nm via a microplate reader (SpectraMax 190, Molecular Devices, CA) to assess the cell growth. Chloehexidine (CHX) and dimethylsulfoxide were used as positive and negative controls, respectively [24]. The concentration of CHX was used in the same range as shown for the monomers.…”

Section: Mic Test For the Synthesized Antibacterialmentioning

confidence: 99%

“…Monomers The minimal inhibitory concentration (MIC) of the synthesized antibacterial monomers was determined following the published protocol with a slight modification [24]. Briefly, colonies of S. mutans (UA159) were suspended in 5 ml of Tryptic soy Broth (TSB) prior to MIC testing.…”

Section: Mic Test For the Synthesized Antibacterialmentioning

confidence: 99%

“…The antibacterial test was conducted following the published procedures [24]. S. mutans was mainly used to evaluate the antibacterial activity of the studied cements throughout the study.…”

Section: Antibacterial Testmentioning

confidence: 99%

“…These materials are found to be capable of reducing the number of bacteria that are resistant to other types of cationic antibacterials [15]. The examples of the QAS-containing materials as antibacterials for dental restoratives include incorporation of a methacryloyloxydodecyl pyridinium bromide as an antibacterial monomer into resin composites [12], use of methacryloxylethyl cetyl ammonium chloride as a com-ponent for antibacterial bonding agents [16,17], addition of quaternary ammonium polyethylenimine nanoparticles into composite resins [18][19][20][21][22][23], and incorporation of polyQAS (PQAS) into glass-ionomer cements (GICs) [24]. All these studies found that the QAS-containing materials did exhibit significant antibacterial activities.…”

Section: Introductionmentioning

confidence: 99%

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Preparation and evaluation of a novel antibacterial glass-ionomer cement

Howard¹,

Weng²,

Huang³

et al. 2013

JBiSE

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A novel antibacterial glass-ionomer cement has been developed. Compressive strength (CS) and S. mutans viability were used to evaluate the mechanical strength and antibacterial activity of the formed cement. Compressive yield strength (YS), modulus (M), diametral tensile strength (DTS) and flexural strength (FS) were also determined. All the formulated antibacterial cements showed a significant antibacterial activity, accompanying with an initial CS reduction. The effect of the synthesized antibacterial polymer loading was significant. Increasing loading from 1% to 20% significantly decreased the S. mutans viability from 3% to 50% and also reduced the initial CS (325 MPa) of the formed cements from 19% to 75%. The cement with 5% antibacterial polymer loading showed 142 MPa, 6.9 GPa, 224 MPa, 52 MPa, and 62 MPa in YS, M, CS, DTS and FS, respectively, as compared to 170, 7.1, 325, 60 and 87 for the experimental cement without antibacterial polymer addition and 141, 6.9, 236, 42 and 53 for Fuji II LC. It was also found that the chlorine-containing antibacterial cement showed better CS values than the bromine-containing cement, with no significant difference in antibacterial activity. The antibacterial cement also showed a similar antibacterial activity to Streptococcus mutans, lactobacillus, Staphylococcus aureus and Staphylococcus epidermidis. The human saliva did not affect the antibacterial activity of the cement. The thirty-day aging study indicates that the cements may have a longlasting antibacterial function.

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Strategies toward development of antimicrobial biomaterials for dental healthcare applications

Parhi

Pal

Das

et al. 2021

Biotech & Bioengineering

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Several approaches for elimination of oral pathogens are being explored at the present time since oral diseases remain prevalent affecting approximately 3.5 billion people worldwide. Need for antimicrobial biomaterials in dental healthcare include but is not restricted to designing resin composites and adhesives for prevention of dental caries. Constant efforts are also being made to develop antimicrobial strategies for clearance of endodontic space prior root canal treatment and for treatment of periimplantitis and periodontitis. This article discusses various conventional | © 2021 Wiley Periodicals LLC Microorganisms Type of disease References Lactobacilli Dental caries Caufield et al. (2015) (Mutans streptococci) Streptococcus mutans, Streptococcus sorbinus Dianawati et al. (2020) Aggregatibacter actinomycetemcomitans Periodontitis Oscarsson et al. (2019) Porphyromonas gingivalis Z. He et al. (2020) Fusobacterium nucleatum Endodontic infection Martinho et al. (2016); Matsui et al. (2014) Enterococcus faecalis Alghamdi and Shakir (2020)

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Preparation and evaluation of a novel glass-ionomer cement with antibacterial functions

Cited by 172 publications

References 27 publications

Antibacterial/Antiviral Property and Mechanism of Dual-Functional Quaternized Pyridinium-type Copolymer

Antibacterial/Antiviral Property and Mechanism of Dual-Functional Quaternized Pyridinium-type Copolymer

Preparation and evaluation of a novel antibacterial glass-ionomer cement

Strategies toward development of antimicrobial biomaterials for dental healthcare applications

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