Preparation and Evaluation of a New Nano Pharmaceutical Excipients and drug Delivery System Based in Polyvinylpyrrolidone and Silicates

Abstract

-Purpose. The aim of this work is to prepare new nanocomposites based on a lamellar silicate alkyl ammonium montmorillonite (AAM) obtained by the intercalation of polyvinylpyrrolidone (PVP K-30) and glyceril monostearate (GME). Methods. AAM was characterized by XRD, TGA and DSC analysis and its compactation characteristics, functionality and toxicity were also tested. The AAM/PVP K-30 and AAM/GME nanocomposites were evaluated by XRD diffratograms to measure the interlamellar spacing values in order to prove the new nanocomposites formation. Tablets were prepared using methyldopa and theophylline as model drugs whereas the dissolution tests were carried out in simulated gastric and enteric fluids. Results. AAM showed a good compactability and compressibility characteristics for tablets preparation. The intercalation yields (~ 25%) of the nanocomposites were efficient. The AAM/PVP K-30 nanocomposites were successfully tested as dissolution enhancers and sustained release matrixes. Conclusions. The results suggest to the promising use of AAM (viscogel B8) and to the new nanocomposite prepared by clay/PVP K-30 intercalation as a new matrix for sustained release. These data also point to the feasibility of using these new nanocomposites as dissolution enhancer. __________________________________________________________________________________________

Evaluation of Nevirapine Release Kinetics from Polycaprolactone Hybrids

“…These new compounds have been increasingly used in biomedical, pharmaceutical and cosmetics applications, presenting many advantages compared with individual polymers or other pharmaceutical excipients, such as: controlled drug release, targeted drug delivery, improved mechanical properties and stability [2] [3]. Furthermore, the effective dispersion and distribution of nanoparticles can modify the drug's release from the polymer matrix [4] [5].…”

Clays as Biomaterials in Controlled Drug Release: A Scientific and Technological Short Review

“…(Table 2) presents the main articles and their peculiarities in the different systems (clay AND drug) used for the purpose of incorporating and releasing the drug in the human organism. Among the evaluated drugs, the classes are: analgesics [4], anticancer [16][17][18] antibiotics, anti-inflammatories [19,20] antibacterials [20][21][22] and vitamins [23][24][25]. The clays, natural or synthetic, that stand out in these studies are: montmorillonite, halloysite, laponite, palygorskite and magnesium phyllosilicates.…”

Review of Clay-Drug Hybrid Materials for Biomedical Applications: Administration Routes

“…Organic drug molecules stabilized in the interlayer space of clay minerals could be oriented with a monolayer, bi-layers, or pseudo-triple layers, or a paraffin-like mono-layer or bi-layer arrangement (Bergaya and Lagaly, 2013), depending not only on the CEC of the clay minerals but also on the amount of drug loaded, resulting in controlled-release and sustained-release properties (Abdel-Mohsen et al, 2001;Takahashi et al, 2005;Jung et al, 2008a;Lvov et al, 2008;Joshi et al, 2009). In addition, clay minerals have been utilized as formulation additives in order to enhance the solubility of poorly soluble drugs (Jung et al, 2008b;Dornelas et al, 2011;Lim et al, 2011) to improve the photo/dispersion/thermal stability of fragile bioactive molecules (El-Nahhal et al, 1999;Cypes et al, 2003;Takahashi et al, 2005;Pongjanyakul et al, 2009), and to provide mucoadhesive properties for increasing retention time in the gastrointestinal (GI) tract and the preocular surface (Dobrozsi, 2003;Hua et al, 2010;Salcedo et al, 2012). The fascinating features of clay-drug hybrid materials allow the potential to develop efficient DDS.…”