Preparation and Characterization of Spherical Agglomerates of Piroxicam by Neutralization Method

Dixit, Marm; Kulkarni, Parthasarathi K.; Selvam, Rajiv; Kini, Ashwini G; Shivakumar, H. G.

doi:10.3923/ajdd.2011.188.199

Cited by 14 publications

(12 citation statements)

References 8 publications

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“…The same solvent composition was used for all crystallization procedures [15]. Based on the high solubility of ketoprofen in IPA (2 g/12.5 ml), high viscosity and crystal morphology of the regenerated product, IPA is the most suitable solvent for the re-crystallization of ketoprofen.…”

Section: Discussionmentioning

confidence: 99%

“…The formation of ketoprofen solid dispersion and ketoprofen-dextran ester prodrug has also been reported to improve ketoprofen solubility and dissolution [12,13]. The mechanism of increased dissolution rate of drugs by solid dispersion crystallization technique has been attributed to a number of factors such as drug amorphization, increased drug solubility, reduction in particle size, a higher degree of surface area and porosity [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Different Crystallization Techniques on the Dissolution Behavior of Ketoprofen

Dixit¹,

Kulkarni²,

Vaghela³

2013

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Different Crystallization Techniques on the Dissolution Behavior of Ketoprofen

Dixit¹,

Kulkarni²,

Vaghela³

2013

Trop. J. Pharm Res

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“…This expected result was due to wetting effect of the hydrophilic polymers (34) . while, the formula prepared by the use of combination of polymers (EBS6) showed greatest improvement in solubility than formulas prepared by single polymer since the use of hydrophilic polymer (PEG4000) survive the spherical shape of particle and enhanced the solubility effect of (β. cyclodextrin) (27,45) (table 2).…”

Section: Solubility Studymentioning

confidence: 99%

“…This could be attributed to the markedly different crystal habits of the samples. Therefore, the related abundance of the planes exposed to the X-ray source would have been changed, producing the variations in the relative intensities of the peak or may be due to the reduction in crystallinity (partial amorphism) of particle cause reduction in intensity of peaks (45,46) .…”

Section: X-ray Diffraction (X Rd)mentioning

confidence: 99%

Formulation and In- Vitro Evaluation of Spherical Crystal Agglomerates of Ebastine by Quasi Emulsion Solvent Diffusion Method

hareeja

Al-Khedairy²

2018

IJPS

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Ebastine (EBS) is a poorly water-soluble antihistaminic drug; it belongs to the class II group according to the biopharmaceutical classification system (BCS). The aim of the present work was to enhance the solubility, dissolution rate and micromeritic properties of the drug, by formulating it as spherical crystal agglomerates by Quasi Emulsion Solvent Diffusion (QESD) method. Spherical crystal agglomerates (SCAs) were prepared in presence of three solvents dichloromethane (DCM), water and chloroform as a good solvent, poor solvent and bridging solvent respectively. Agglomeration of EBS involved the use of some hydrophilic polymers like polyethylene glycol 4000 (PEG 4000), polyvinyl pyrrolidine K30 (PVP K30), D-?-tocopheryl polyethylene glycol 1000 succinate (TPGS) and ?. cyclodextrin. The pure drug (EBS) and its agglomerates with and without polymers were characterized for their drug content, percentage yield, solubility, in vitro drug release study and micromeritic property as well as by optical microscope, Scanning Electron Microscopy (SEM), FTIR spectroscopic studies, Differential Scanning Calorimetry (DSC) and X-ray Diffraction (XRD). The results of this work showed that there was a marketed enhancement in the solubility with improvement in dissolution rate, physiochemical properties, decrease in crystallinity and alteration in the crystal habit of the drug especially in presence of polymers. The best results were obtained with formula prepared by the combination of PEG 4000 and ?. cyclodextrin in the agglomeration process of (EBS).

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“…Mel powder was dissolved in 0.1 N sodium hydroxide (good solvent) with the aid of heat until a clear solution was obtained. The drug solution was poured into 0.1 N hydrochloric acid (poor solvent) containing HPbCD at a concentration of 0.0125% w/v under continuous stirring at 600 rpm (Dixit et al, 2011) with a propeller at room temperature. After the crystallization of Mel, chloroform (bridging solvent) was added, in two portions and the system was agitated for 30 min then the prepared agglomerates were collected by filtration through Whatman Õ filter paper.…”

Section: Preparation Of Mel Spherical Crystalline Agglomeratesmentioning

confidence: 99%

Particle engineering/different film approaches for earlier absorption of meloxicam

et al. 2014

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Meloxicam (Mel) is a non-steroidal potent anti-inflammatory drug with effective analgesic effect for various situations; e.g. postoperative pain. The early systemic exposure to Mel and hence the rapid onset of pharmacological action is limited by its poor water solubility; a situation which may be more pronounced during acute pain episode because of reduced gastric motility that affects disintegration and dissolution of solid dosage forms. To overcome delayed absorption of Mel, improvement in the dissolution behavior of Mel is essential. Firstly, Mel spherical crystalline agglomerates (SCA) were prepared. Secondly, selected Mel SCA were integrated into intraoral fast disintegrating (OF) and edible (EF) films, they possess larger surface area that leads to rapid disintegration and release of the drug into the oral cavity within seconds and hence a rapid onset of action could be achieved. Stability study of formulations resulting in faster and higher extent of dissolution and suitable mechanical properties (G3 and G12) revealed their physical and chemical stability after three months of storage under different conditions. Both G3 and G12 successfully offered rapid absorption rate and accordingly an earlier systemic exposure to Mel compared to Mobic tablets as revealed by significantly earlier T and higher AUC and AUC. T following G3 fast disintegrating film administration was comparable to that reported following Mel parenteral administration but avoiding patient inconvenience. Both films may be suitable alternative to conventional oral and intramuscular Mel especially when earlier onset of action is required (in acute conditions).

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Preparation and Characterization of Spherical Agglomerates of Piroxicam by Neutralization Method

Cited by 14 publications

References 8 publications

Effect of Different Crystallization Techniques on the Dissolution Behavior of Ketoprofen

Effect of Different Crystallization Techniques on the Dissolution Behavior of Ketoprofen

Formulation and In- Vitro Evaluation of Spherical Crystal Agglomerates of Ebastine by Quasi Emulsion Solvent Diffusion Method

Particle engineering/different film approaches for earlier absorption of meloxicam

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