Particle engineering/different film approaches for earlier absorption of meloxicam

Abstract

Meloxicam (Mel) is a non-steroidal potent anti-inflammatory drug with effective analgesic effect for various situations; e.g. postoperative pain. The early systemic exposure to Mel and hence the rapid onset of pharmacological action is limited by its poor water solubility; a situation which may be more pronounced during acute pain episode because of reduced gastric motility that affects disintegration and dissolution of solid dosage forms. To overcome delayed absorption of Mel, improvement in the dissolution behavior of Mel is essential. Firstly, Mel spherical crystalline agglomerates (SCA) were prepared. Secondly, selected Mel SCA were integrated into intraoral fast disintegrating (OF) and edible (EF) films, they possess larger surface area that leads to rapid disintegration and release of the drug into the oral cavity within seconds and hence a rapid onset of action could be achieved. Stability study of formulations resulting in faster and higher extent of dissolution and suitable mechanical properties (G3 and G12) revealed their physical and chemical stability after three months of storage under different conditions. Both G3 and G12 successfully offered rapid absorption rate and accordingly an earlier systemic exposure to Mel compared to Mobic tablets as revealed by significantly earlier T and higher AUC and AUC. T following G3 fast disintegrating film administration was comparable to that reported following Mel parenteral administration but avoiding patient inconvenience. Both films may be suitable alternative to conventional oral and intramuscular Mel especially when earlier onset of action is required (in acute conditions).

In vitro/in vivo evaluation of an optimized fast dissolving oral film containing olanzapine co-amorphous dispersion with selected carboxylic acids

“…First, the film was wrapped in butter paper as one layer and above which a second layer of aluminum foil was tightly applied. Samples of the optimized films were stored at 40 C/75% RH for a period of 12 weeks (Akil et al, 2011;Farid et al, 2015). Periodically, samples were withdrawn at different predetermined time intervals (0, 1, 2, 4, 6, 9, and 12 weeks) and examined physically for any changes in color, appearance thickness, and surface pH as well as chemically for their drug content.…”

D-optimal mixture design for optimization of topical dapsone niosomes: in vitro characterization and in vivo activity against Cutibacterium acnes

“…The power law model equation was used to assess the flow behavior of OF-gel where τ is the shear stress (dyne/cm 2 ), K is the consistency index (dyne/cm 2 .s), γ is the shear rate (s −1 ), and n is the flow index. In case of Newtonian systems, n value is one, while it is between zero and one for a shear thinning system and larger than one in case of a dilatant system (Farid et al., 2016 ; Said et al., 2017 ).…”

Formulation, characterization, optimization, and in-vivo performance of febuxostat self-nano-emulsifying system loaded sublingual films

“…The thickness was measured using Vernier caliper micrometer (Shanghai, China) at five different locations (four corners and one at center) for each film and the average of five readings for each film was taken (Farid et al, 2016 ).…”