Preparation and characterization of poly(lactic acid)/poly(methyl methacrylate) blend tablets for application in quantitative analysis by micro Raman spectroscopy

Abstract

Poly(lactic acid) (PLA) is a biodegradable polymer that has a variety of applications, one of which is as biomaterial in surgery or as functional layers on implants, due to its compatibility with living tissue. This paper reports the possibilities of quantification of poly(lactic acid) (PLA) in a polymer matrix such as poly(methyl methacrylate) (PMMA) by micro Raman spectroscopy (MRS). Blends of amorphous poly(DL‐lactic acid) with poly(methyl methacrylate) were prepared by the procedure of dissolution/precipitation. Thermal properties of the blends such as the glass transition temperature (Tg) were characterized by differential scanning calorimetry (DSC). The PLA/PMMA blends exhibited only a single glass transition region, indicating that this system is miscible. The PLA/PMMA system obeys the Gordon–Taylor equation (Tg versus PLA content). Various concentration ratios of PLA blends were prepared to use as a basis for quantitative analysis by MRS. Intensities of the characteristic bands at 813 cm−1 (νCOC of PMMA) and 873 cm−1 (νC―COO of PLA) were used for the calculation. The calibration graph showed a good linear correlation with an R2 value of 0.9985. On the basis of the calibration curve obtained, the determined content of several PLA/PMMA blends was in good agreement when compared with nominal contents. The limit of detection (LOD) and quantification (LOQ) were calculated by the calibration data set as signal‐to‐noise method. The relative standard deviation of this method was lower than 10% and the accuracy better than 4%. This study demonstrated that Raman spectroscopy provides an alternative non destructive method for quantitative analysis of PLA in a PMMA matrix. Copyright © 2015 John Wiley & Sons, Ltd.

Miscible blends of biobased poly(lactide) with poly(methyl methacrylate): Effects of chopped glass fiber incorporation

“…[36][37][38][39][40][41][42] Recently, PMMA has received great interest as a blend candidate for PLA due to its higher glass transition temperature and complementary mechanical properties. 38,[43][44][45][46][47][48][49][50][51][52][53][54] However, conclusions regarding the miscibility of PLA/PMMA blends are somewhat contradictory in the literature. Samuel et al report that blends prepared by solvent casting are immiscible.…”

New Generation of Tunable Bioactive Shape Memory Mats Integrated with Genetically Engineered Proteins

“…Figure illustrates the Raman spectra for both PLLA/PMMA‐only and PLLA/PMMA with GFP‐HABP fibers incubated either in biomineralization buffer only (vehicle control) or biomineralization buffer with the addition of AP enzyme to catalyze mineral formation. The peaks at 812 cm −1 are associated with COC symmetric stretching of the PLLA/PMMA polymer blend . The bands at 960 cm −1 are characteristic of PO symmetric stretching in phosphate groups, as noted in hydroxyapatite mineral .…”

“…The peaks at 812 cm −1 are associated with COC symmetric stretching of the PLLA/PMMA polymer blend. [29] The bands at 960 cm −1 are characteristic of PO symmetric stretching in phosphate groups, as noted in hydroxyapatite mineral. [28] For each mineralized fiber sample, a ratio was taken of the 960 and 812 cm −1 bands to measure differences in the degree of mineralization.…”

Recent advances in linear and non‐linear Raman spectroscopy. Part X

“…PLA is a biodegradable polymer that has a variety of applications, one of which is as biomaterial in surgery or as functional layers on implants, due to its compatibility with living tissue. This study demonstrated that Raman spectroscopy provides an alternative non‐destructive method for quantitative analy of PLA in a PMMA matrix …”

“…This study demonstrated that Raman spectroscopy provides an alternative non-destructive method for quantitative analy of PLA in a PMMA matrix. [129] Glasses, ceramics, powders and disordered materials Di Genova and co-workers described an approximate chemical analysis of volcanic glasses using Raman spectroscopy. They anticipate its application in handheld in situ terrestrial field studies of silicate glasses under extreme conditions, such as extraterrestrial and submarine environments.…”