Preparation and characterization of interpenetrating polymer network beads for controlled release of acebutolol hydrochloride

Abstract

Graft copolymer of sodium alginate (SA) with N-vinyl-2-pyrrolidone (N-VP) was prepared using potassium persulphate (PPS) as an initiator. The effect of monomer content on the percentage of graft yield was investigated. It was observed that N-vinylpyrrolidone (N-VP) content has remarkable influence on the percentage graft yield. SA and their graft copolymer (SA-g-VP) beads were prepared in various formulations using glutaraldehyde (GA) as a cross-linking agent and acebutolol hydrochloride (ABHCl) as a model drug. Beads were characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). Chemical stability of ABHCl after encapsulation into beads was confirmed by FT-IR analysis. Preparation conditions of the SA-g-N-VP beads were optimized by considering the percentage entrapment efficiency, particle size, swelling capacity, and their release data. In vitro release studies of different formulations were performed at 37 • C in an intestinal fluid atmosphere (pH 7.4). The effect of graft copolymer, cross-linker and drug concentrations on the release of ABHCl was discussed. It was observed that ABHCl release from the beads increased with the increasing N-VP upto 30%, and then decreases beyond this concentration. It was also observed that, as GA and ABHCl concentration increases, rate of drug release decreases. The highest ABHCl release upto 12 h was obtained is 98.5%% for beads cross-linked with 0.5 mL GA containing 10% monomer and 10% ABHCl. From these studies, it was observed that SA on grafting with N-VP showed variation in drug release profiles. C 2011 Wiley Periodicals, Inc. Adv Polym Techn 00: 1-13, 2011; View this article online at wileyonlinelibrary.com.

Preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents

“…Using a UV-Vis spectrophotometer, the concentration of OFLX was determined at the λ max of 287.6 nm and that of KP was measured at the λ max of 254.7 nm. To determine the release kinetics of MPs, the release curves were fitted into different kinetic models (including the zero-order model, the first-order model, the Higuchi model, and the Korsmeyer–Peppas model) (Costa & Sousa Lobo, 2001 ; Venkata Prasad et al, 2012 ; Dozie-Nwachukwu et al, 2017 ). Based on the correlation coefficients, the best drug release kinetics model was identified (Arhewoh & Okhamafe, 2004 ).…”