Sodium carboxymethylcellulose/poly (vinyl alcohol) mixed matrix membranes filled with different amounts 4A zeolite (0,5,10,15, and 20 wt %) were prepared by solution casting method. Prepared membranes were crosslinked with GA and used for pervaporation dehydration of isopropyl alcohol of different feed mixtures at 35 C. On increment in zeolite content in the membrane it was found the improvement in the performance of the membrane, due to its hydrophilic nature and molecular sieving effect in addition to its favorable interaction with hydrophilic sodium carboxymethylcellulose and polyvinyl alcohol. The structure and chemical constituents of the MMM's were investigated by attenuated total reflectance Fourier transform infrared spectroscopy. Thermal stability of the membranes was assessed by DSC and TGA techniques. Crystallinity of the membranes was assessed using X-ray diffraction, and the morphological properties were assessed by scanning electron microscopy. Mechanical properties were also carried out to determine the tensile strength and % of elongation at break using universal testing machine. It was found that the mechanical strength increases with increase in the zeolite content upto 15 wt % of zeolite with an optimum tensile strength of 113.31 N/mm 2 . Pervaporation was carried out to asses the membrane performance, the highest flux and selectivity obtained is 0.584 kg/m 2 /h and 6945 for NaCMCA20 and NaCMCA15, respectively, for a feed composition containing 17.5 and 10 wt % of water in the feed and further swelling studies also supporting the pervaporation results.
New anti-HIV active agents, polyrotaxane-AZT conjugates with various bioactive bulky stoppers such as 3 0 -azido-3 0 -deoxythymidine (AZT) and tocopherol and their nanoparticles were synthesized and characterized. The degree of AZT substitution of the conjugates was calculated from ELEM. ANAL and ranged from 1.8 to 5.9, respectively. The in vitro antiviral activity of these conjugates was determined and used to evaluate their potential applications in anti-AIDS drugs. The in vitro anti-HIV activities indicate that the synthesized polyro-taxane-AZT conjugates and their nanoparticles against HIV-1 and HIV-2 strains were more potent inhibitors than free AZT, with reduced cytotoxicities against uninfected MT-4 cells. The effect of the conjugates against HIV-1 and HIV-2 strains increased with decreasing particle size. V C 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 50: [4895][4896][4897][4898][4899][4900][4901] 2012
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