Preparation and characterization of drug-loaded chitosan-tripolyphosphate microspheres by spray drying

Desai, Kashappa Goud H.; Park, Hyun Jin

doi:10.1002/ddr.10416

Cited by 132 publications

(99 citation statements)

References 31 publications

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“…Further, it was observed that percentage of swelling decreased as the concentration of TPP was increased. The results were in agreement with previous studies (19,20). Table II shows the percentage entrapment efficiency of formulations.…”

Section: Swelling Studysupporting

confidence: 92%

In Vitro and In Vivo Studies on Chitosan Beads of Losartan Duolite AP143 Complex, Optimized by Using Statistical Experimental Design

Madgulkar¹,

Bhalekar²,

Swami³

2009

AAPS PharmSciTech

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Abstract. The aim of the present research work was to develop release modulated beads of losartan potassium complexed with anion exchange resin, Duolite AP143 (cholestyramine). Chitosan was selected as a hydrophilic polymer for the formation of beads which could sustain the release of the drug up to 12 h, along with drug resin complex (DRC). Chitosan beads were prepared using an in-liquid curing method by ionotropic cross-linking or interpolymer linkage with sodium tripolyphosphate (TPP). The formulation of the beads was optimized for entrapment efficiency and drug release using 3 2 full factorial design. The independent variables selected were DRC/chitosan and percent of TPP. The optimization model was validated for its performance characteristics. Studies revealed that as the concentration of chitosan and TPP was increased, entrapment efficiency and the drug release were found to increase and decrease, respectively. The swelling capacity of chitosan-TPP beads decreased with increasing concentration of TPP. The effect of chitosan concentration and percentage of TPP solution used for cross-linking on entrapment efficiency and drug release rate was extensively investigated. Optimized beads were subjected to in vivo studies in Wistar albino rats to determine the mean arterial blood pressure and compared with marketed formulation. The pharmacodynamic study demonstrates steady blood pressure control for optimized formulation as compared to fluctuated blood pressure for the marketed formulation.

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Section: Swelling Studysupporting

confidence: 92%

In Vitro and In Vivo Studies on Chitosan Beads of Losartan Duolite AP143 Complex, Optimized by Using Statistical Experimental Design

Madgulkar¹,

Bhalekar²,

Swami³

2009

AAPS PharmSciTech

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“…Some interesting drug delivery systems based on hydrogels have thus been proposed [5][6][7] . Among hydrogels, however, considerable research attention has been ORIENTAL JOURNAL OF CHEMISTRY www.orientjchem.org focused on so-called "smart" hydrogels which can transfer their volume in response to environmental stimuli, and these results in environmental stimuli modifying drug release.…”

Section: Introductionmentioning

confidence: 99%

Biosuperabsorbent Hydrogel Based on Alginate-g-poly AA/kaolin Composite for Releasing Cefalexin Drug

Sadeghi¹,

Shafiei²,

Mohammadinasab³

2014

Orient. J. Chem

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To following synthesis of a novel alginte-based composite superabsorbent hydrogel was through crosslinking graft copolymerization of acrylic acid onto alginate in presence kaolin, we investigated the usefulness of a pH-sensitive protein-based hydrogel for in vitro controlled release of cefalexin. The loading drug yield was found to depend on the incubation time, the amount of encapsulated drug. In addition, the release of cefalexin from this kind of hydrogel was studied. The release rate of cefalexin from hydrogel at pH 7.4 was faster than that at pH 1.6 due to the shrinkage of the hydrogel at pH 1.6.

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“…It is biocompatible, biodegradable, easily formed into structures under mild processing conditions and can be chemically modified, so it is a natural choice as drugdelivery carrier [6,7], cartilage/skin tissue engineering Derm Matrix Composite Materials scaffolds [8][9][10], and regenerative membrane [11]. The physical properties of a polymer can be altered by introducing a second polymer that improves the properties of the original polymer in certain aspects, such as hydrophobility, cell compatibility.…”

Section: Introductionmentioning

confidence: 99%

Preparation, properties, and cell attachment/growth behavior of chitosan/acellular derm matrix composite materials

Lü¹,

Li²,

Zhang³

et al. 2011

JBNB

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Composite membranes and sponge scaffolds consisting chitosan (CS) and acellular derm matrix (ADM) in six ratios were prepared by solvent evaporation technique and freeze-drying method, respectively. The composite materials were characterized by water contact angle measurement, scanning electron microscopy (SEM), water absorption and HaCat cells compatibility. The SEM result showed that CS/ADM three-dimensional (3D) micro-porous structures were successfully produced. The water absorption value of all scaffolds was over 18 times of its initial weight, which is high enough for skin regeneration scaffold, but there were no significant differences of water absorption ratio between deionized water and PBS solution for same scaffold (P > 0.05). HaCat cells were distributed uniformly on the surfaces of membrane 4 -6, and an almost confluent monolayer was formed on membrane 6 on the fifth day, whereas cells maintained round and spherical in shape on the surface of membrane 1. The results showed that the cell compatibility of pure CS membrane needed to be improved, and addition of ADM realized this purpose. The results of compatibility of HaCat cells on scaffolds showed that the cell proliferated well on the scaffolds 3 and 4. In our study, the cell's attachment and growth on the composite membranes was mainly determined by the content of the membrane, whereas the cell's attachment and growth in the scaffolds was determined by both the content and structure of the scaffolds.

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Preparation and characterization of drug-loaded chitosan-tripolyphosphate microspheres by spray drying

Cited by 132 publications

References 31 publications

In Vitro and In Vivo Studies on Chitosan Beads of Losartan Duolite AP143 Complex, Optimized by Using Statistical Experimental Design

In Vitro and In Vivo Studies on Chitosan Beads of Losartan Duolite AP143 Complex, Optimized by Using Statistical Experimental Design

Biosuperabsorbent Hydrogel Based on Alginate-g-poly AA/kaolin Composite for Releasing Cefalexin Drug

Preparation, properties, and cell attachment/growth behavior of chitosan/acellular derm matrix composite materials

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