Biosuperabsorbent Hydrogel Based on Alginate-g-poly AA/kaolin Composite for Releasing Cefalexin Drug

Abstract

To following synthesis of a novel alginte-based composite superabsorbent hydrogel was through crosslinking graft copolymerization of acrylic acid onto alginate in presence kaolin, we investigated the usefulness of a pH-sensitive protein-based hydrogel for in vitro controlled release of cefalexin. The loading drug yield was found to depend on the incubation time, the amount of encapsulated drug. In addition, the release of cefalexin from this kind of hydrogel was studied. The release rate of cefalexin from hydrogel at pH 7.4 was faster than that at pH 1.6 due to the shrinkage of the hydrogel at pH 1.6.

Exploration of Macroporous Polymeric Sponges As Drug Carriers

“…Most of the carriers using a mesoporous system showed a drug loading capacity below 1000 mg/g, even when very high drug concentration was applied. − Another broadly used carrier system is metal organic frames (MOFs). − These materials yielded a drug loading capacity below 750 mg/g and the applied drug concentration below 30 mg/mL. Fibers and hydrogels were also reported as drug carriers, but their drug loading capacity was even lower, smaller than 500 mg/g. − Nanotubes in dispersion, serving as drug carriers, exhibited high drug loading capacity. − These preparations possessed a drug loading capacity of up to 1500 mg/g when applying very low drug concentration (10–80 mg/mL). However, in comparison, our fibrous sponge carrier exhibited superior drug loading capacity.…”

“…Comparison of drug loading capacity by sponges and other supports. Fibers (TiO 2 , 44 SiO 2 −AgNPs 45 ), ordered mesoporous system (SiO 2 , 34,35 TiO 2 −SiO 2 , 36 SiO 2 −Al 2 O 337 ), hollow sphere/ mesoporous shell (SiO 238 ), metal organic frames (MOF; Crbased, 39,40 Zn-based,41 Zr-BPYDC,42 Zn-TATAT43 ), dispersion (nanotubes,47 functionalized C-MPG148 ), nanocarrier (calcium phosphate-AC and calcium phosphate-ibuprofen49 ), and hydrogel (alginate-g-polyAA/kaolin46 ).…”