Preparation and Characterization of Comb-like PEO Gradient Surfaces

Jeong, Bong Jin; Lee, Jin Ho; Lee, Hai Bang

doi:10.1006/jcis.1996.0174

Cited by 73 publications

(46 citation statements)

References 9 publications

(11 reference statements)

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“…The absorbance ratio was divided RESULTS AND DISCUSSION by the number of ether carbons per PEO chain since the absorbance ratio does not directly relate to the grafted amount for the PEO-MA with different PEO Characterization of comb-like PEO chain lengths. 49 As seen in Figure 5, the grafted amount gradient surfaces of PEO-MA increased as the PEO chain length in the PEO-MA decreased. This may be attributed to the steric The corona-treated PE surface did not show any interference of longer PEO side chains in PEO-MA visible changes, but with increasing corona power the macromers since it was reported that the lengths of water contact angles of the surface gradually decreased macromer side chains do not have a pronounced effect along the sample length (Fig.…”

mentioning

confidence: 84%

“…14,15,22,23 Adsorbed PEO-containing block copolymers would be tion of poly(ethylene glycol) monomethacrylates (PEO-MA) with different PEO chain lengths (1, 5, and 10) more stable than PEO homopolymers since the hydrophobic block segments provide hydrophobic adsorpwas performed. 49 The corona-induced graft copolymerization method seems simpler and more practical than tion forces for anchoring to the polymer substrate. Due to its simplicity and nonspecificity, this method would the plasma-induced one because the samples are discharged in air at atmospheric pressure whereas they seem to be applicable to many biomedical areas.…”

Section: Introductionmentioning

confidence: 99%

“…49 From the ESCA carbon 1S spectra of clean bench at room temperature. The platelet-attached the PEO-MA-grafted PE surfaces, we also observed surfaces were gold deposited in vacuum and examined that the ether carbon peak (binding energy, ȁ286.6 eV) by SEM with a tilt angle of 45Њ.…”

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confidence: 99%

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Plasma protein adsorption and platelet adhesion onto comb-like PEO gradient surfaces

Lee¹,

Jeong

Lee

1997

J. Biomed. Mater. Res.

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146

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Comb-like polyethylene oxide (PEO) surfaces were prepared on low-density polyethylene (PE). The comb-like PEO chain density was changed gradually along the sample lengths by corona discharge treatment with gradually increasing power and the following graft copolymerization of poly(ethylene glycol) monomethacrylate macromers (PEO-MA). The macromers with different PEO repeat unit, 1, 5, and 10, were used. The prepared comb-like PEO gradient surfaces were characterized by water contact angle, Fourier transform infrared spectroscopy in the attenuated total reflectance mode, and electron spectroscopy for chemical analysis. All these measurements indicated that the PEO chains are grafted on the PE surface with gradually increasing density of PEO. Plasma protein adsorption and platelet adhesion on the PEO gradient surfaces decreased with increasing PEO chain length and surface density. As observed by scanning electron microscopy, PEO10-MA-grafted surface with high PEO density was very effective in preventing protein adsorption and platelet adhesion and did not activate the platelets.

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confidence: 84%

Section: Introductionmentioning

confidence: 99%

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Plasma protein adsorption and platelet adhesion onto comb-like PEO gradient surfaces

Lee¹,

Jeong

Lee

1997

J. Biomed. Mater. Res.

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146

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“…Reactive functional groups use initiating species such as free radicals or peroxides which are generated on polymer substrates by ultraviolet (UV) irradiation, [23][24][25] high-energy ␥-irradiation, [26][27][28] plasma discharge, 29,30 or corona discharge. 31,32 Methoxy PEG monomethacrylate macromers are commonly used to prepare this type of PEO surface.…”

Section: Introductionmentioning

confidence: 99%

Platelet adhesion onto segmented polyurethane surfaces modified by PEO- and sulfonated PEO-containing block copolymer additives

Lee

et al. 1998

J. Biomed. Mater. Res.

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Polyethylene oxide (PEO) surfaces were prepared by the addition of PEO- and sulfonated PEO-containing amphiphilic block copolymers as surface-modifying additives in a segmented polyurethane (PU). PEO-PPO-PEO triblock copolymers (Pluronics) with different PEO chain lengths (from 2 to 80) were used as additives. The prepared film surfaces were characterized by the measurement of dynamic water contact angles and electron spectroscopy for chemical analysis. It was observed that the PU films containing 10 wt% of PEO additives were surface-saturated with the additives regardless of their PEO chain length, but the PEO chains were more projected from the film surfaces containing the additives with longer PEO chains. The water absorption of the films increased largely with the increasing PEO chain length of the additives. The addition of PEO additives produced film surfaces that were in a gel-like state. The films demonstrated some extraction of the PEO additives. However, the additives with higher molecular weights were entrapped more stably into the PU matrix. The mechanical properties (tensile strength and elongation) of the films were changed by the addition of PEO additives, but the differences were not significant compared to the control PU. The platelet adhesion on the film surfaces decreased with increasing PEO chain length of the additives. The film surface containing additives with long PEO chains (chain length of 80) was particularly effective in preventing platelet adhesion. The effect of negatively charged sulfonate groups on the prevention of platelet adhesion appeared only on the film surfaces containing additives with short PEO chains. For longer PEO chains, the chain mobility effect was more dominant than the negative charge effect on the prevention of platelet adhesion.

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“…[7,8] A number of techniques to generate gradients on various substrates have been reported, including diffusion-controlled vapor deposition, [1] cross diffusion, [9,10] corona discharge, [11,12] photoimmobilization, [13,14] electrochemical-potential gradients, [5,[15][16][17] the use of microfluidic devices, [18,19] and, more recently, surface-initiated polymerization through atom-transfer radical polymerization (ATRP). [7,8,[20][21][22][23][24][25][26] ATRP is of special interest because of its versatility, robustness, controllability, the living nature of the polymerization, [27][28][29][30] and as a facile route to surface-grafted polymers, which are attractive because they can be used to tailor surface properties such as wettability, biocompatibility, adhesion, adsorption, corrosion resistance, and friction.…”

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confidence: 99%

Spatiotemporally Controlled Formation of Two‐Component Counterpropagating Lateral Graft Density Gradients of Mixed Polymer Brushes on Planar Au Surfaces

Wang

Bohn

2007

Advanced Materials

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Preparation and Characterization of Comb-like PEO Gradient Surfaces

Cited by 73 publications

References 9 publications

Plasma protein adsorption and platelet adhesion onto comb-like PEO gradient surfaces

Plasma protein adsorption and platelet adhesion onto comb-like PEO gradient surfaces

Platelet adhesion onto segmented polyurethane surfaces modified by PEO- and sulfonated PEO-containing block copolymer additives

Spatiotemporally Controlled Formation of Two‐Component Counterpropagating Lateral Graft Density Gradients of Mixed Polymer Brushes on Planar Au Surfaces

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