Preparation and characterization of biodegradable poly(trimethylenecarbonate‐ε‐caprolactone)‐block‐poly(p‐dioxanone) copolymers

Abstract

A series of poly(trimethylenecarbonate-e-caprolactone)-block-poly(p-dioxanone) copolymers were prepared with varying feed rations by using two step polymerization reactions. Poly(trimethylenecarbonate)(e-caprolactone) random copolymer was synthesized with stannous-2-ethylhexanoate and followed by adding p-dioxanone monomer as the other block. The ring opening polymerization was carried out at high temperature and long reaction time to get high molecular weight polymers. The monofilament fibers were obtained using conventional melting spun methods. The copolymers were identified by 1 H and 13 C NMR spectroscopy and gel permeation chromatography (GPC). The physicochemical properties, such as viscosity, molecular weight, melting point, glass transition temperature, and crystallinity, were studied. The hydrolytic degradation of copolymers was studied in a phosphate buffer solution, pH ¼ 7.2, 37 8C, and a biological absorbable test was performed in rats. V V C 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: [2790][2791][2792][2793][2794][2795][2796][2797][2798][2799] 2005

Development of 3-D poly(trimethylenecarbonate-co-ε-caprolactone)-block-poly(p-dioxanone) scaffold for bone regeneration with high porosity using a wet electrospinning method

“…It has been used to make monofilament sutures with good tenacity and high knot security (Gesti et al 2007;Sabino et al 2000;Yang et al 2005). PPDO degrades slowly compared to poly(lactide) (PLA) and poly(glycolide) (PGA) due to its low physical and mechanical properties characterized (Hong et al 2005(Hong et al , 2006. As soft segments, ecaprolactone (CL) and trimethylenecarbonate (TMC) moieties can endow the PPDO chain with enhanced flexibility and degradability, and excellent handling characteristics, increasing the possibility of P(TMC-co-CL)-b-PPDO as a promising biodegradable scaffold.…”

Improving the ring-opening polymerization of ε-caprolactone and l-lactide using stannous octanoate

“…However, most are air sensitive and difficult to control without the glove box and vacuum lines. Stannous octanoate (Sn(Oct) 2 ) is a common catalyst used in the applications [19][20][21][22][23][24][25][26][27][28][29][30][31][32] and manufacturing of polyester due to its low sensitivity to air, low catalytic concentration, high conversion ratio, and acceptance by the FDA as an approved catalyst for certain polymers used in coatings that contact food [33]. However, the drawbacks include low polymerization activity and undesirable inter-and intramolecular transesterification reactions.…”

Synthesis and thermal properties of novel multiblock biodegradable copolymers derived from polyethylene glycol, ε -caprolactone and p-dioxanone

“…From a mechanical point of view, it is classified as a brittle material with a high elastic modulus. But because of the presence of five methylene moieties in the polymer backbone the modulus is lower than that of polylactide 8,9 . Unique properties of polyethylene glycol include: solubility in water and many organic solvents, lack of solubility in hexane and ethyl ether, lack of toxicity, FDA approval for internal consumption, rapid clearance from the body, lack of immunogenicity, and high mobility and large exclusion volume in water.…”